OSP FO# 11-222

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Institute of Mental Health (NIMH)/National Institute on Alcohol Abuse and Alcoholism (NIAAA)

PROGRAM: Molecular and Cellular Substrates of Complex Brain Disorders (R01 & R21)

OBJECTIVES: This program provides funding for research grant applications that seek to identify the most promising and innovative leads at the interface between cellular and molecular mechanisms and disease-associated processes, with the goal of accelerating progress in emerging areas of research relevant to complex brain disorders. Applications in response to this program can be fundamentally discovery-based rather than hypothesis-driven, and should seek to develop a better understanding of the molecular and cellular changes in neurons and their signaling mechanisms potentially associated with disease.

Applications aimed at the molecules and cellular mechanisms associated with these brain disorders may include studies of perturbations in neurotransmitters, neuropeptides, bioactive lipids, neuromodulators, and neurotrophins; receptors and ion channels; second and third messenger systems; protein translation, modification, degradation; membrane biology; bioenergetics; neuron-glia communication; oxidative, immunological, and inflammatory mechanisms; and alterations in spine morphology and/or synaptic connectivity.

Examples of relevant research include, but are not limited to:

  • Studies aimed at determining the biological function of newly identified genetic variants and pathways associated with brain disorders where genetic drivers and neuropathological markers have yet to be established.
  • Exploratory in vitro studies that apply state of the art signal transduction and genetic approaches to identify new molecular entities critical for neuronal signaling in the context of disorders with the ultimate purpose of exploring pathological mechanisms or to identify novel treatment targets. This includes the development of new scalable assays of neuronal mechanisms.
  • Implementation of novel cellular models derived from human brain disorders (e.g., induced pluripotent stem (iPS) cells) to identify disease associated alterations in cell processes.
  • Studies of novel roles for molecules linked to disease but for which the basic neurobiology has not yet been established. Examples include the impact of immune molecules or neurodevelopmental factors on synaptic plasticity and dendritic structure.
  • Development/optimization of model organism or scalable technologies for analyzing the expression levels and biological functions of brain signaling molecules in brain disorders.

Please see the program announcement below for further program details.

R01: February 5, June 5, and October 5, until September 8, 2014
R21: February 16, June 16, and October 16, until September 8, 2014

FUNDING INFORMATION: These programs will utilize the NIH Research Project Grant (R01), and the NIH Exploratory/Developmental (R21) award mechanisms, and “Just-in-Time” information concepts. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. For the R01 program, budgets are not limited, but need to reflect actual needs of the proposed project. The scope of the proposed projects should determine the project period. The maximum period is 5 years.

The total project period for an R21 application submitted in response to this solicitation may not exceed two years. Direct costs are limited to $275,000 over the two-year period, with no more than $200,000 in direct costs allowed in any single year.

Chiiko Asanuma, Ph.D.
National Institute of Mental Health
6001 Executive Boulevard, Room7183, MSC 9641
Bethesda, Maryland 20892
Telephone: (301) 443-5288
Email: cs2j@nih.gov
Web: R01: http://grants.nih.gov/grants/guide/pa-files/PAR-11-299.html
R21: http://grants.nih.gov/grants/guide/pa-files/PAR-11-300.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (PAR-11-299 and PAR-11-300) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact either India Adams (adamsi@bu.edu) or A. B. Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.