OSP FO# 11-218

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/Basic Behavioral and Social Science Opportunity Network (OppNet)/National Cancer Institute (NCI)/National Eye Institute (NEI)/National Heart, Lung, and Blood Institute (NHLBI)/National Human Genome Research Institute (NHGRI)/National Institute on Aging (NIA)/National Institute on Alcohol Abuse and Alcoholism (NIAAA)/National Institute of Allergy and Infectious Diseases (NIAID)/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)/National Institute of Biomedical Imaging and Bioengineering (NIBIB)/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/National Institute on Deafness and Other Communication Disorders (NIDCD)/National Institute of Dental and Craniofacial Research (NIDCR)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institute on Drug Abuse (NIDA)/National Institute of Environmental Health Sciences (NIEHS)/National Institute of General Medical Sciences (NIGMS)/National Institute of Mental Health (NIMH)/National Institute of Neurological Disorders and Stroke (NINDS)/National Institute of Nursing Research (NINR)/National Institute on Minority Health and Health Disparities (NIMHD)/National Library of Medicine (NLM)/Fogarty International Center (FIC)/National Center for Complementary and Alternative Medicine (NCCAM)/National Center for Research Resources (NCRR)/Office of Behavioral and Social Sciences Research (OBSSR)/Office of Dietary Supplements (ODS)/Office of Rare Diseases (ORD)/Office of Research on Women’s Health (ORWH)

PROGRAM: Sleep and Social Environment: Basic Biopsychosocial Processes (R21)

OBJECTIVES: This program provides funding to investigate the reciprocal interactions of the processes of sleep and circadian regulation and function with behavioral and social environment processes. This program provides a unique opportunity to link social environment factors that shape sleep behaviors with the direct neurobehavioral and circadian biology effects of sleep processes on individuals (both men and women) in the context of their social milieu. The research gap to be addressed lies between the understanding of the behavioral choices of individuals and social units, such as families and work groups, that determine sleep and circadian regulation (e.g., 24/7 media content, artificial light exposure, self-imposed sleep debt) and individual susceptibility to decrements in neurobehavioral and social functioning arising from phenotypic, genotypic, and gene by environment interactions. Possible differential effects of so-called “forced” choices not to sleep due to overriding responsibilities (such as parenting) versus “optional” choices (such as partying) are unknown. Applicants are encouraged to develop theoretical models that capture social and behavioral interactions associated with sleep disturbance in social environments, including residential, employment, and school settings, while simultaneously incorporating biobehavioral markers of high and low susceptibility to sleep debt.

The goal of this program is to stimulate research that will investigate the biopsychosocial mechanisms underlying the reciprocal and dynamic relationships between behavioral and social environment factors on the one hand and basic sleep and circadian regulation and function on the other. Two broad categories of applications are responsive to this initiative: 1. Human or animal studies of the biological sequelae of changes in basic behavioral patterns of sleep duration and timing as a function of determinants from the social environment; 2. Human or animal studies of the dynamic relationships of individuals’ behaviors in social interactions as a function of sleep or circadian rhythms. These studies may have implications with broad social significance or more localized implications for individual health related behavior.

Appropriate topics include, but are not limited to, those listed below:

  • Studying the underlying mechanisms of behavioral and social environmental dynamics that affect individual choices for sleep and their subsequent consequences for circadian biology
  • Mechanisms of sleep and circadian biology that lead to variation in individual behavior and cumulate in altered social environments
  • Studies using animal models to evaluate the influences of altered circadian rhythms and/or sleep on social behavior and the molecular and genetic mechanisms involved
  • Studies using animal models to analyze the effects of disruptions in social behavior on sleep and circadian rhythms and investigation of the underlying genetic and neurochemical mechanisms

Please see the program announcement below for further program details.

Full Application: September 30, 2011, 5PM local time

FUNDING INFORMATION: This program will utilize the NIH Exploratory/Developmental (R21) award mechanism, and “Just-in-Time” information concepts. OppNet anticipates providing $1 million for FY2012 to fund 4-5 awards. Direct costs are limited to $275,000 over a two-year period, with no more than $200,000 in direct costs allowed in any single year. The total project period for an application submitted in response to this funding opportunity may not exceed 2 years.

Rosalind B. King, Ph.D.
Demographic and Behavioral Sciences Branch (DBS)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
6100 Executive Boulevard, Room 8B07, MSC 7510
Bethesda, Maryland 20892-7510
Telephone: (301) 435-6986
Fax: (301) 496-0962
Email: rozking@mail.nih.gov
Web: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-12-204.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (RFA-HD-12-204) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact either India Adams (adamsi@bu.edu) or A. B. Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.