OSP FO# 11-174

AGENCY: Burroughs Wellcome Fund

PROGRAM: Investigators in the Pathogenesis of Infectious Disease

OBJECTIVES: This program provides funding for accomplished investigators still early in their careers to study the pathogenesis of infectious disease at its most fundamental level—the points where human and microbial systems connect. The program supports research that sheds light on the fundamentals that affect the outcomes of this encounter: how colonization, infection, commensalism, and other relationships play out at levels ranging from molecular interactions to systemic ones. The Burroughs Wellcome Fund is interested in work focused on the host, as well as host-pathogen studies originating in viral, bacterial, fungal, or parasite systems. Studies supported by the program may have their roots in the pathogen, but the focus of the work should be on the interplay of host and microbe. While work on AIDS, malaria, tuberculosis, and microbes of interest for biodefense is allowed, the program emphasizes areas of research that open up unexplored areas of pathogenesis. Research on under-studied infectious diseases, including pathogenic fungi, protozoan and metazoan diseases, and emerging infections is especially of interest. Interdisciplinary approaches are encouraged.

The awards are intended to give recipients the freedom and flexibility to pursue high-risk projects and new avenues of inquiry. Work supported will be efforts that have the potential to significantly advance the understanding of how microbes and the human system interact especially in the context of infection. Biochemical, pharmacological, molecular, genetic, immunologic, and other approaches are all appropriate for support by the program. Areas of particular interest include: cell/pathogen interactions, host/pathogen interactions, and novel routes to disease causation.

ELIGIBILITY RESTRICTIONS: An Eligibility Quiz has been created to assist determining the eligibility of applicants for this award. Successful completion of the Quiz will take candidates directly to the pre-proposal application. Applicants will be notified upon conclusion of the Quiz if they are eligible to continue the application and apply for the grant.

Candidates must be nominated by accredited, degree-granting institutions in the United States or Canada. A U.S. or Canadian institution, including its medical school, graduate schools, and all affiliated hospitals and research institutes, may nominate up to two candidates. However, institutions that nominate a candidate who holds a Doctorate of Veterinary Medicine (D.V.M.) will be permitted to nominate one additional candidate. Also, institutions may have one additional nomination if they nominate a researcher working in pathogenic helminthes, mycology, or reproductive science. This brings the total number of nominations allowed by an institution to four: two standard nominations, one additional nomination for a D.V.M., and one additional nomination for a candidate working in the areas listed above.

Candidates will generally have an M.D., D.V.M., or Ph.D. degree and must be citizens or permanent residents of the United States or Canada at the time of application. Candidates must have an established record of independent research and hold a tenure-track position as an assistant professor or equivalent at the time of application.

B.U. Internal Deadline: September 19, 2011
Nomination Deadline: November 1, 2011, 4:00pm

FUNDING INFORMATION: This program will provide awards for $500,000 disbursed over a period of five years ($100,000 per year). No more than $20,000 of the award may be used annually for the grantee’s salary support, including fringe benefits. Indirect costs may not be charged against the award. Grantees must devote at least 75 percent of their time to research-related activities.

Jean Kramarik, Senior Program Associate
Burroughs Wellcome Fund
21 T. W. Alexander Drive
Research Triangle Park, North Carolina 27709
Telephone: (919) 991-5122
Fax: (919) 991-5160
Email: jkramarik@bwfund.org
Web: http://www.bwfund.org/page.php?mode=privateview&pageID=75

INTERNAL REVIEW PROCESS: Each institution is permitted to nominate two individuals. Additional nominations may be made if an institution nominates a candidate who holds a Doctorate of Veterinary Medicine (D.V.M) or is working in pathogenic helminthes, mycology, or reproductive science, bringing the total nominations permitted to four. Faculty wishing to be considered for nomination should provide the following proposal material to OSP-CRC Director Joan Kirkendall, Office of Sponsored Programs, 25 Buick Street, Boston, MA 02215, for internal review purposes:

(1) Letter of recommendation from the appropriate Department Chair or Research Mentor, highlighting the nominee’s achievements and outlining the nominee’s level of experience and independence;

(2) Description of the nominee’s proposed research project (maximum length 3 pages); including the rationale for the proposed work, its potential importance, and the approach to be taken;

(3) Nominee’s biographical sketch (2 pages).

Nomination material will be collected and forwarded to the Office of the Vice President for Research for final selection. All nomination material should be received by Monday, September 19, 2011.

REMARKS: Applications must be submitted electronically via the Burroughs Wellcome proposal submission website (https://www.grantrequest.com/sid_227/) according to the instructions contained in the program guidelines.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.