OSP FO# 11-164

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Institute of General Medical Sciences (NIGMS)

PROGRAM: NIGMS National Centers for Systems Biology (P50)

OBJECTIVES: This program provides funding to establish National Centers that promote institutional development of pioneering research, training, and outreach programs focused on quantitative, systems level analysis of biological phenomena of biomedical importance within the NIGMS mission. The NIGMS supports fundamental inquiries focused on bioinformatics and computational biology, molecular and cell biology, biophysics, genetics and developmental biology, biochemistry, pharmacology, anesthesiology, selected aspects of the behavioral sciences, and human physiology in the areas of shock, trauma, burn, wound healing, inflammation, and multi-organ failure. This program does not support research focused on diseases or organ systems that fall within the purview of other Institutes and Centers within the NIH.

NIGMS National Centers for Systems Biology will be expected to provide national leadership in systems biology research, research training, and knowledge dissemination. They will accomplish this goal through the development of truly innovative programs that establish new research areas and a new research culture, to develop and distribute enabling technologies, and to train a new generation of systems biologists. Centers should design their programs with the goal of serving scientific communities beyond the participating investigators and institutions. This can be achieved through research collaborations, facility support, visiting investigatorships, fellowships, workshops, summer courses, internships, symposia, Center websites, and/or other means. Research training and education should be a significant component of the Centers. To maximize the impact, Centers should conduct research training at multiple levels from undergraduate education to professional career development that are appropriate to their institutions. At the student level, applicants are expected to identify current educational gaps and needs and to propose creative responses. At the professional level, Centers should propose plans to support and nurture junior and new investigators. Incorporation of developmental research projects led by new investigators in the Center research and development plan is strongly encouraged. Outreach to the groups of individuals underrepresented in biomedical research is required. Over a period of time, Centers should evolve into highly integrated research, training, and knowledge-exchange headquarters that will make substantial contributions in the emerging field of systems biology.

The Center will be expected to have a Scientific Advisory Board, drawn from experts outside the project, which will meet annually to review and provide guidance on Center activities. Funded Centers are required to attend annual meetings of the NIGMS National Centers for Systems Biology. Applicants should have a plan to construct a Center web site for the dissemination of research data, software, and other resources of the project. A software dissemination plan, with appropriate timelines, must be included in the application.

Please see the program announcement below for further program details.

ELIGIBILITY: The Project Director/Principal Investigator (PD/PI) of a center grant must commit a minimum effort of 30% or 3.6 months per year to the project.

Letter of Intent (optional): September 28, 2011
Proposal Due Date: October 27, 2011

FUNDING INFORMATION: This program utilizes the NIH Specialized Center (P50) award mechanism. NIGMS intends to commit $7 million to support two new and/or renewal applications. Applicants may request up to $2 million per year for five years. Funds for initial large equipment may be requested in excess of this $2 million limit if prior approval is obtained. Only one renewal will be allowed for each award, making the total length of support for any P50 Center under this program limited to a maximum of ten years.

James J. Anderson, Ph.D.
Center for Bioinformatics and Computational Biology
45 Center Drive
Building 45, 2AS-25A
Bethesda, MD 20892
Telephone: (301) 594-0943
Fax: (301) 480-2228
Email: andersj@mail.nih.gov
Web: http://grants.nih.gov/grants/guide/pa-files/PAR-10-200.html

REMARKS: The PHS 398 application instructions are available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, Telephone (301) 435-0714, Email: GrantsInfo@nih.gov.

Complete program guidelines and application material (PAR-10-200 and PHS 398) may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.