OSP FO# 11-129

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)

PROGRAM: NHLBI Systems Biology Collaborations (R01)

OBJECTIVES: This program provides support for a coordinated “systems biology” approach to understanding the normal physiology and perturbations associated with heart, lung, blood, and sleep (HLBS) diseases and disorders. The goal of this program is to improve our understanding of complex HLBS biological systems through the development of predictive mathematical models that make new testable predictions of how the biological system will respond to perturbations seen during development, adaptation, or disease. The mathematical model proposed in the application must: 1) recapitulate the known characteristics of a biological system; and 2) predict responses of the system to novel perturbations. While bioinformatic and statistical expertise may be essential components of research proposed under this program, proposals must include predictive, mechanistic, quantitative models that generate testable hypotheses about the physiological and pathophysiological mechanisms that underlying the responses to perturbation.

Topics may include but are not limited to the following:

- Development and validation of innovative-computational approaches to integrate diverse data types into predictive quantitative models for improved understanding and prediction of HLBS function
- Development of multiscale computational models of the heart, lung or blood vessels for use as virtual tools for studying, testing, refining and predicting various physiological and pathological conditions
- Development of personalized treatment strategies for red cell disease from a mechanistic understanding of the impact of changes in the networks and pathways that regulate red cell differentiation
- Integration of imaging and ‘omic’ data to define factors of plaque vulnerability
- Modeling responses and regulation of the networks and pathways that underlie HLBS function in health and their changes in adaptation and disease, through integrated computational and experimental approaches
- Integration of metabolomic measures with genetic data to understand the progression from risk factor(s) to subclinical and clinical disease
- Research using systems approaches to investigate interactions between the pulmonary vasculature and the heart and to characterize transcription factors and gene networks regulating lung vascular function during development, injury, remodeling, and repair
- Understanding the role of carbohydrate structures in inflammatory illnesses or development of cardiovascular disease in humans
- Use of systems approaches to manipulate adhesivity of white blood cells to the blood vessel wall
- Understanding and predicting dynamic responses of HLBS systems
- Understanding mechanistic basis of acute and chronic adaptations to the pulmonary system in COPD (chronic obstructive pulmonary disorder)
- Studies that predict cell fate differentiation of cardiac stem cells through integration of genetic networks with physical stress-strain information from the cell environment
- Modeling flow and rheology for blood cells in small vessels

Please see the program announcement below for further program details.

Letter of Intent (optional): August 14, 2011 and December 14, 2011
Full Proposal: September 14, 2011 and January 13, 2012

FUNDING INFORMATION: This program will utilize the NIH Research Project Grant (R01) mechanism. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

Jennie Larkin, Ph.D.
Division of Cardiovascular Diseases
National Heart, Lung, and Blood Institute
Rockledge 2, Room 8200
6701 Rockledge Dr.
Bethesda, MD 20892-7940
Telephone: (301) 435-0513
Fax: (301) 480-1454
Email: LarkinJ2@nhlbi.nih.gov 
Web: http://grants.nih.gov/grants/guide/pa-files/PAR-09-214.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (PAR-09-214) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact either India Adams (adamsi@bu.edu) or A. B. Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.