OSP FO# 11-084
AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Institute of General Medical Sciences (NIGMS)
OBJECTIVES: This program provides support for proposals to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. Proposals should work to solve a substantial biological problem for which the determination of many protein structures is necessary. The proteins should be amenable to high-throughput structure determination or should provide suitable targets to motivate new technology development. The proteins generally should be of unknown structure and preferably likely to be of novel structure. Ideally, the solution of these protein structures will also contribute to the understanding of protein sequence-structure relationships in general. The project should involve both functional studies by the applicant researchers and structural studies by the PSI:Biology network. Projects may focus on proteins that are the subject of other grant proposals, but the specific aims must clearly differ, both with respect to functional studies to be conducted and with respect to the goal of structure determination.
It is expected that these awards will lead to new collaborations between researchers emphasizing biological function and researchers emphasizing biological structure, and that the results from these collaborations will contribute to understanding many basic and biomedically important research problems as well as to our fundamental understanding of protein structure.
The areas of research that interest NIGMS include, but are not limited to:
- protein evolution
- metabolic pathways
- cellular complexes
- membrane proteins
- disease-specific single nucleotide polymorphism (SNPs)
- nucleic acids and nucleic-acid protein complexes
- sequence/structure coverage for defined subsets of sequence space
- functional inference generation and characterization for proteins of unknown function
This program is a part of the new NIGMS initiative, PSI:Biology (http://www.nigms.nih.gov/Initiatives/PSI/Biology/). The goal of the PSI:Biology initiative will be to test whether the new paradigm of high-throughput structure determination via highly organized networks of investigators can be applied to a broad range of biological problems.
Letter of Intent (optional): 30 days before the anticipated receipt date
Full proposal: June 5, October 5, and February 5, until September 8, 2014.
FUNDING INFORMATION: Budgets are expected to be in the range of $250,000 to $1.5 million in direct costs (up to $2.5 million total costs) per year for project periods of 2–4 years.
Ward W. Smith, Ph.D.
Division of Cell Biology and Biophysics
National Institute of General Medical Sciences (NIGMS)
45 Center Drive, MSC 6200
Building 45, Room Number 2AS.19F
Bethesda, MD 20892
Telephone: (301) 443-9375
Fax: (301) 480-2004
REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (PAR-11-176) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.
For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact either India Adams (firstname.lastname@example.org) or A. B. Effgen (email@example.com) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.
Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or firstname.lastname@example.org, or visit the OSP web site at http://www.bu.edu/osp.