OSP FO# 11-042

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Institute of Nursing Research (NINR)

 PROGRAM: Acute Life Threatening Conditions and Opportunities for Palliative and End of Life Care Research (R01)

OBJECTIVES: This program provides funding to:

(a)  Examine predictors of progression to life threatening illness, End of Life (EOL) issues, and death among individuals diagnosed with acute illnesses in the presence of underlying chronic diseases, adverse health risk factors, or other negative variables.

(b)  Develop algorithms for such adverse progressions to life limiting disease or EOL.

(c)  Examine the burden of illness imposed by acute illnesses when superimposed on individuals with underlying chronic diseases or other negative variables/adverse risk factors (such as age) that carry the potential to exacerbate and/or potentiate the impact of the acute illness and/or the severity or prognosis of the underlying chronic disease such that progression to End of Life can occur.

(d)  Explore the trajectories of disease in these individuals and their covariates, and issues and needs among such patients and their caregivers.

(e)  Identify the complex palliative and End of Life Care issues and needs arising as a result of the multi factorial etiology and co-occurrence of two (or more) co-existing diseases or negative variables.

(f)  Study the medical, physical and psychosocial inter-relationships between disease status, symptoms, psychosocial or functional status, spiritual concerns and the impact of such key variables on both length and/or QOL.

(g)  Develop and test appropriate palliative and End Of Life care interventions for individuals with acute illnesses occurring in the presence of underlying chronic diseases or adverse risk factors leading to severe illness requiring complex palliative care or End of Life care.

(h)  Assess similarities and differences in palliative and or EOL Care needs, issues, barriers, or success among those whose progression to the EOL phase is sudden compared to those progressing to this phase gradually or as a function of time.

(i)  Examine the impact on, needs of, and interventions for the caregivers of this population.

This program also encourages applicants to explore the complex needs of the population that is the focus of the program; to study the medical, physical, and psychosocial relationships between disease status, symptoms, psychological, functional conditions, spiritual concerns, and QOL; and to develop and test appropriate palliative and EOL care interventions for those with advanced HF and their caregivers. This concept is consistent with the NINR Strategic Plan area of Quality of Life, Symptom Management, Palliative Care and End of Life. Examples of appropriate areas of interest that fall within the scope of this program include, but are not limited to, the following:

-    Examine predictors of progression to life threatening illness, End of Life (EOL), and death among individuals diagnosed with acute illnesses in the presence of underlying chronic diseases, adverse health risk factors, or other negative variables.

-    Develop algorithms for such adverse progressions to life limiting disease or EOL.

-    Identify biomarkers associated with increased risk of mortality among persons with concurrent acute and chronic illness.

-    Explore unique needs by ethno-cultural background, age or medically underserved group status.

-    Study physical and psychosocial relationships between various trajectories and severities of disease.

-    Examine the impact of interventions on symptom management with attention to symptom onset, duration, severity, and overall burden.

For more research topics, please consult the program announcement below. The R01 grant mechanism solicits empirical, hypothesis-driven, confirmatory research and modeling approaches.

DEADLINES:
Letter of Intent (optional): March 14, 2011
Full Proposal: April 14, 2011

FUNDING INFORMATION: This program will utilize the NIH Research Project Grant (R01) award mechanism, and “Just-in-Time” information concepts. The NINR anticipates providing $2 million to support up to 4–5 new grants in FY 2011. Budgets for direct costs are limited to $300,000 per year. The total project period for an application submitted in response to this funding opportunity may not exceed 4 years.

AGENCY CONTACT:
Noreen Aziz, MD, PhD, MPH
National Institute of Nursing Research (NINR)
National Institutes of Health
6701 Democracy Boulevard
One Democracy Plaza
Bethesda, MD 20892-4870
Telephone: (301) 594-2542
Fax: (301) 480-8260
Email: azizn@mail.nih.gov
Web: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-11-008.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (RFA-NR-11-008) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact A. Brink Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.