OSP FO# 11-041

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Institute of Nursing Research (NINR)

 PROGRAM: Personalized Genomics for Symptom Management: Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R01, R21)

OBJECTIVES: This program provides funding to support the study of: 1) the role of genomic variants in the observed inter-individual variation in the onset, sensitivity, duration, and severity of symptoms and/or responses to therapies designed to prevent, alleviate, or eliminate symptoms, and 2) the role of non-genomic influence(s) that may potentially moderate the effects of genomic variants in the manifestation of symptoms and/or response to treatment.

Symptoms are the result of a complex interaction of biological, cognitive, behavioral, sociocultural, spiritual, and environmental factors. Symptoms include but are not limited to anxiety, depression, cognitive dementia, nausea, diarrhea, pain, fatigue, insomnia, loss of appetite, dyspnea, and oral dryness. To stimulate research that will link basic genomic discovery to the prevention and alleviation of symptoms in patients suffering from chronic disorders, this program’s areas of interest include but are not limited to:

-    the identification of associations of genomic variants with the onset and manifestation of symptoms related to chronic diseases;

-    the elucidation of the functional properties of genomic variants identified through Genome-Wide Association Studies (GWAS) and other genotyping studies, including the effects of the variant(s) on gene expression and protein function and how these functions relate to symptom etiology and/ or response to treatment

-    the exploration of physiological, behavioral and environmental factors such as age, gender, coping skills, prior experiences, sociocultural and psychosocial background, etc. and the role of the factor(s) in moderating the effects of genomic variants in the development and manifestation of symptoms and/ or response to treatment;

-    the development of models that incorporate genomic variant information with physiological, behavioral, and/ or environmental factors in predicting an individual’s risk for developing and manifesting symptoms and/ or response to treatment.

The application must clearly describe the contribution of the proposed work in facilitating a personalized genomics approach for symptom management, including descriptions of relevant future studies (for example, comparative effectiveness research) that will be needed to build on the proposed work to successfully translate the research into evidence-based strategies designed to improve patient outcomes. Interdisciplinary collaborations that include nurse scientists in the project team are strongly encouraged. Applicants should consider incorporating measures from the PhenX toolkit (https://www.phenxtoolkit.org/) where applicable.

Letter of Intent (optional): March 18, 2011
Full Proposal (R01 and R21): April 18, 2011

FUNDING INFORMATION: These programs will utilize the NIH Research Project Grant (R01), and the NIH Exploratory/Developmental (R21) award mechanisms, and “Just-in-Time” information concepts. The NINR intends to commit an estimated total of $2 million split between the R01 program and R21 program.

For the R01 program, direct costs are limited to a maximum of $300,000 per year, and a project duration of up to 3 years. For the R21 program, the total project period may not exceed two years and direct costs are limited to $275,000 over a two-year period, with no more than $200,000 in direct costs allowed in any single year.

Lois A. Tully, PhD
Program Director
National Institute of Nursing Research (NINR)
National Institutes of Health
6701 Democracy Boulevard
One Democracy Plaza
Bethesda, MD 20892-4870
Telephone: (301) 594-5968
Fax: (301) 480-8260
Email: tullyla@mail.nih.gov
Web:  R01: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-11-003.html
R21: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-11-004.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact A. Brink Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.