OSP FO# 11-040

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

PROGRAM: Intellectual and Developmental Disabilities Research Centers 2011 (P30)

OBJECTIVES: This program provides funding to support interdisciplinary research and research training for a program of intellectual and developmental disabilities (IDD) research. Research conducted in Intellectual and Developmental Disabilities Research Centers (IDDRCs) covers a broad spectrum of scientific approaches ranging from laboratory research on fundamental processes of normal and abnormal development to clinical and behavioral research that studies persons with IDD.

NICHD strongly encourages translation of basic research observations into patient-oriented protocols whose ultimate aims are to validate the mechanistic basis of IDD in humans, and to develop new approaches for the prevention, diagnosis and treatment of IDD. Consequently, applications for IDDRC Core Grants (P30) should include investigators studying a range of topics in basic and clinical or applied research. NICHD encourages, but does not require, applicants to include both biomedical and behavioral/biobehavioral components among the topics addressed within their Center. Topics of research may include, but are not limited to:

-    Developmental and neurobiological studies to define the molecular and cellular bases of IDD and to facilitate development of specific hypotheses about basic abnormalities that underlie these conditions.

-    Studies of cellular and molecular aspects of brain development: differentiation, synapse formation and modification, plasticity, trophic factors, and neurotransmitter function and modulation as possible mechanistic substrates for IDD.

-    Creation and characterization of animals that, through genetic alteration, model specific important aspects of IDD by clear neurodevelopmental, pathophysiological, genetic, and/or functional homology, and their use to test existing drugs and to develop new drugs that are safe and effective for individuals with IDD.

-    Studies that develop and test novel methods and measures for screening and diagnosis, and/or identify children and infants at risk; validation of emerging technologies (e.g., microarrays, proteomics, microanalysis of analytes, biomolecule detection, mass spectrometry, functional imaging) for screening and diagnosis.

-    Studies involving manipulations of interaction between behavior and environment of individuals with IDD throughout the life-span to reduce behavior problems or to facilitate vocational training, social and self-help skills, and learning; use of social support networks; parent-child, sibling, peers, and family interactions over the life-span.

-    Studies of socio-ecological processes: individuals with IDD from various cultural and ethnic groups in multiple settings (naturalistic observation); ethnographic research, life history reporting, and systematic observation of specific activities.

-    Studies that develop and utilize assistive devices (e.g., computer software, hand-held devices, and touch screen computers) to help individuals with IDD to learn and communicate.

NICHD encourages cooperation among the Centers, including their integration into a network that may facilitate the infrastructure necessary to conduct larger research programs or clinical trials. The applicant institution and pertinent departments must show a strong commitment to the Center’s support. Dedicated space and/or equipment, staff recruitment, investigators’ salaries, or other financial support for the proposed Center exemplify such commitment. The facilities should require no more than modest alteration and/or renovation. NICHD provides no funds for new construction. Scientific personnel and institutional resources must be available to provide a strong research base in the specified fields. For more information, please consult the program announcement below.

ELIGIBILITY RESTRICTIONS: NICHD does not award more than IDDRC grant (P30) per institution. Applications for P30 IDDRC grants must propose a program consisting of cores to be accessed by grants that propose research addressing at least five topics relevant to the research mission of IDD. The program should consist of at least 10 externally funded research projects grouped according to relevant topics. The specific research projects must be (1) relevant to the mission of NICHD’s IDD Center programs; (2) of a quality acceptable to NICHD; and (3) funded when the P30 award (initial or renewal) begins. For more information, please consult the program announcement below. Please consult the program announcement for a complete list of requirements IDDRCs must satisfy.

DEADLINE:
Internal BU Deadline: February 25, 2011
Application Deadline: March 22, 2011

FUNDING INFORMATION: This program utilizes the NIH Center Core Grants funding (P30) award mechanism, and “Just-in-Time” information concepts. NICHD intends to commit $6.79 million in FY 2011 for 5 awards. The total project period for an application submitted in response to this program may not exceed 5 years. A new application may request up to $750,000 in direct costs the first year. Renewal applications may request up to $750,000 or up to 1 percent above the direct costs awarded in the final noncompeting (Type 5) year.

AGENCY CONTACT:
Melissa A. Parisi, M.D., Ph.D.
Intellectual and Developmental Disabilities Branch
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
6100 Executive Boulevard
Room 4B09, MSC 7510
Bethesda, MD 20892
Rockville, MD 20852 (for express/courier service; non-USPS service)
Telephone: (301) 435-6880
Fax: (301) 496-3791
Email: parisima@mail.nih.gov
Web: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-10-022.html

INTERNAL REVIEW PROCESS: To screen potential proposals for this competition, an internal deadline has been established. Principal Investigators (PIs) interested in submitting a proposal should provide the following proposal information to their Associate Dean by Friday, February 25, 2011 for internal review purposes:

1. Project description (maximum length 4 pages) should include items a–d:

(a) discuss the philosophy and objectives of the Center and general plans for the proposed research, addressing five topics relevant to the mission of IDD for the grant period;
(b) describe the strategic vision and the way in which the Center will implement this vision and which future directions will likely be followed during the project period;
(c) explain how the program functions as a true “Center” rather than a collection of unrelated support services; and
(d) provide a management plan for the Center and integrated Core units.

2. Budget, and budget justification (2 pages).

3. Biographical sketches: include NIH format biographical sketch for PI and Senior/Key Personnel.

4. Review comments from any previous P30 submission.

Following the Dean’s assessment of the internal application, it will be forwarded to OSP-CRC Director Joan Kirkendall for review and then to the Office of the VP for Research for final selection. PIs will be informed if their proposal is selected for submission in time to complete and process their proposal for final review.

REMARKS: Complete program guidelines and application material (RFA-HD-10-022 and PHS 398) may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.