OSP FO# 11-037

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Human Genome Research Institute (NHGRI)

PROGRAM: Informatics Tools for High-Throughput Sequence Data Analysis (U01)

OBJECTIVES: This program provides support to fund the further development of existing computational software tools for use with contemporary DNA sequencing technology in order to make those tools sufficiently robust, reliable, well-documented, and well-supported that they can be readily adopted by any biological or biomedical research laboratory. The existing “in-house” software from which proposals for this FOA should start can come from any appropriate source, including software developed at existing sequencing centers (which NHGRI regards as a resource when developed through the NHGRI large-scale sequencing program), or from companies or academic laboratories that work with sequence data.

The further development of these existing tools should give them high utility in terms of the potential number of users and/or ease of use, high significance in terms of the specific capabilities they enable, and to make them readily transferrable, with excellent documentation for installation and use, and appropriate user support. Access to the tools and underlying code should be high as well, for example through deposition in a suitable repository (e.g. SourceForge).

Applications are sought that propose either to develop stand-alone tools, or to bundle software tools into a coherent suite or package. Applications that run in a cloud environment are encouraged. Because this initiative seeks to foster the creation of robust, transferable software tools that will be useful to the community, applicants should address several points:

-  The software should perform reliably and precisely according to the computing demands of end-users.

-  The algorithms that are employed by the software should be well documented, as should be the assumptions underlying these algorithms.

-  Contemporary software should be fully documented and easy to modify and extend. Defects that arise in any software must be correctable with limited effort.

-  As the needs of a community of users change, the software that supports their research efforts must be easily modified. “Reparability” and “evolvability” are particularly important.

-  Interoperability and portability are also a major concern. Where appropriate, software applications should operate on a variety of platforms employing different operating systems.

A software dissemination plan, with appropriate timelines, is expected to be included in the application. There is no prescribed single license for software produced, however reviewers will be asked to evaluate the dissemination plan based on its likely impact. For more information, please consult the program announcement below.

DEADLINE: March 3, 2011

FUNDING INFORMATION: This program will use the NIH U01 Cooperative Agreement award mechanism, and “Just-in-Time” information concepts. NIH anticipates providing $16 million ($4 million per year) to fund up to 10 awards. Application budgets are limited to $750,000 direct costs for up to 4 years.

Adam Felsenfeld, Ph.D.
Program Director
The Division of Extramural Research
5635 Fishers Lane, Suite 4076, MSC 9305
National Human Genome Research Institute (NHGRI)
National Institutes of Health
Bethesda, MD 20892-9305
FedEx/UPS/Courier Delivery should use: Rockville, MD 20852
Telephone: (301) 496-7531
Fax: (301) 480-2770
Email: adam_felsenfeld@nih.gov
Web: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-018.html

REMARKS: Complete program guidelines and application material (RFA-HG-10-018 and PHS 398) may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.