OSP FO# 11-036

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/National Cancer Institute (NCI)

PROGRAM: Cancer Prevention Research Small Grant Program (R03)

OBJECTIVES: This program provides funding to enhance both basic and applied cancer prevention research pertinent to the development of cancer chemoprevention agents, biomarkers for early cancer detection, cancer-related nutrition science, and/or clinical prevention studies that focus on specific target organs. Proposed projects may involve basic animal and/or translational research and/or human subjects-oriented research that is hypothesis driven. The areas of research may include, but are not limited to:

-    identification, development, and evaluation of biological analytic techniques, methodologies, and clinical technologies relevant to pre-clinical cancer detection and prevention of primary and recurrent primary cancers;

-    development and evaluation of new high-throughput genomic- and proteomic-based detection techniques, as well as of measures of improved sensitivity, specificity, validity, and safety;

-    translational research to facilitate the transfer of new technologies (to the clinical setting) for earlier detection, prevention, and risk assessment;

-    development and evaluation of computer-based data monitoring systems for analysis and interpretation of laboratory data on multiple markers of and for the development of modeling systems based on molecular, genetic, and other risk factors to be used in the evaluation of cancer prevention approaches; and for the development of modeling systems pertinent to these areas;

-    preclinical selection and evaluation of potential biomarker candidates using animal models (i.e., mouse) of human cancer;

-    evaluation of molecular targets for the potential to prevent, reverse, or retard progression of precancerous lesions (and, hence, the cancer process) by natural or synthetic chemopreventive agents;

-    investigation of mechanisms of action of chemopreventive agents.

For more research topics, please consult the program announcements below. The R03 grant mechanism is intended to support pilot and feasibility studies; small, self-contained research projects; development of research methodology; and development of new research technology that can be carried out in a short period of time with limited resources. Specific projects proposed in response to this program are expected to attempt only to obtain preliminary data and/or conduct pilot/feasibility studies to facilitate the development of future, more detailed and expanded research projects.

DEADLINES: March 18, July 21, and December 16, 2011

FUNDING INFORMATION: This program will utilize the NIH Small Research Grant (R03) award mechanism, and “Just-in-Time” information concepts. The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications. Budgets for direct costs of up to $50,000 per year, and a project duration of up to two years may be requested, for a maximum of $100,000 over a two-year project period.

AGENCY CONTACT:
Marjorie Perloff, MD
Chemopreventive Agent Development Research Group
Division of Cancer Prevention
National Cancer Institute (NCI)
6130 Executive Boulevard, EPN, Room 2112
Bethesda, MD 20892 (USPS)
Rockville, MD 20852 (courier service)
Telephone: (301) 594-0466
Fax: (301) 402-0553 or (301) 594-2943
Email: perloffm@mail.nih.gov
Web: http://grants.nih.gov/grants/guide/pa-files/PAR-11-079.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (PAR-11-079) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact A. Brink Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.