Training Faculty for the PhD in Neuroscience: Charles River Campus (CRC) & Boston University Medical Campus (BUMC)
The following is our list of training faculty that are currently serving, or have previously served, as mentors for GPN students either for rotations or thesis research. Please go to the main faculty list of the website to identify other opportunities for training in the outstanding neuroscience laboratories located on the campuses of Boston University.
Carmela Abraham, Ph.D. (Professor, Member of the GPN GEC, Department of Biochemistry (BUMC)) studies the mechanisms of brain aging and the etiology of Alzheimer’s disease (AD). The 40-42 amino acid amyloid beta peptide (Aß) is the major component of plaques that accumulate in the brains of AD patients and are believed to cause irreversible mental deterioration. Formation and clearance of the neurotoxic Aß are major therapeutic targets for the treatment of AD. Aß is a proteolytic fragment of the amyloid precursor protein (APP), a ubiquitously expressed and conserved protein., The Abraham laboratory is conducting a screen to identify inhibitors of APP dimerization, because of its importance for Aß production, and has identified a proteolytic activity involved Aß degradation. Her laboratory also studies the aging rhesus monkey as a model for normal human brain aging because they develop cognitive impairment with age. To their surprise, they could not detect cortical neuronal loss, but extensive changes in the white matter and particularly in myelin. They attribute these changes that occur with aging to neuroinflammation, a major area of their research interests along with the anti-aging gene Klotho that is markedly reduced in oligodendrocytes.
Sudha Arunachalam, Ph.D. (Assistant Professor, Department of Speech, Language, and Hearing Sciences). Her current focus is on studying the mechanisms underlying the acquisition and processing of language in young children. One area of research compares language acquisition in typically-developing children and children with neurodevelopmental disorders such as autism, and another focuses on the consolidation of linguistic memories during sleep.
Helen Barbas, Ph.D. (Professor, Department of Health Sciences, Sargent College, Professor, Department of Anatomy and Neurobiology (CRC/BUMC)) focuses on the organization of the prefrontal cortex and its role in central executive functions in primates. The goal is to investigate prefrontal pathways that interface with both excitatory and inhibitory neurons in cortical and subcortical structures that may provide the basis for the selection of relevant information and suppression of irrelevant information in behavior. Research involves investigation of bidirectional pathways between prefrontal cortices and structures associated with sensory, cognitive, mnemonic and emotional processes in the cortex, the thalamus, and the amygdala. Experimental approaches include the use of neural tracers to label pathways, combined with histochemical, immunocytochemical and molecular procedures to characterize the postsynaptic site of prefrontal pathways. We use quantitative approaches and imaging to reconstruct in 3D neural circuits at the level of systems and at the synaptic level, and employ multidimensional analyses to reveal patterns and principles of connections.
Michael Baum, Ph.D. (Professor, Department of Biology (CRC)) focuses on the mechanisms controlling the sexual differentiation and adult display of courtship behaviors in mice. One project uses transgenic mice in which the /Cyp-19 /(aromatase) gene has been disabled to study the role of the sex hormone, estradiol, in the differentiation of female-typical aspects of courtship behavior, including olfactory responses to conspecifics. Another project concerns the interaction between the main and accessory olfactory nervous systems in the control of mate recognition and sexual motivation in male and female mice. Techniques that used include brain immunocytochemistry to localize neuronal immediate-early gene products, steroid hormone receptors and several neuropeptides; in situ hybridization autoradiography to localize and quantify mRNAs for pheromone receptors in the vomeronasal organ; the quantitative analysis of sexual, scent marking, and olfactory behaviors as well as operant methods for assessing animals’ ability to detect pheromones as well as their sexual partner preferences; and brain infusions of neurotoxins, tract tracers and neuropeptides to study the olfactory mechanisms controlling sociosexual behaviors.
J. Krzysztof Blusztajn, Ph.D. (Professor, Department of Pathology (BUMC)) studies the effects of perinatal availability of an essential nutrient, choline, on brain development and aging in experimental animals. This research endeavors to determine why it is that supplementation with choline during critical perinatal periods in rats and mice causes a long-term facilitation of visuospatial memory which persists until old age. To this end they are utilizing biochemical, neuroanatomical, and behavioral techniques in a highly unified experimental design. Their studies to date have focused on the development of the basal forebrain cholinergic system, hippocampal MAPK and CREB signaling, and on the developmental patterns of brain gene expression. They are also the first to show that choline nutrition in pregnancy alters the epigenome of the brain.
Jason Bohland, Ph.D. (Assistant Professor, Department of Health Sciences, Sargent College (CRC)) focuses on understanding the structural and functional architecture of neural circuits in the human brain, with emphasis on those that support speech and language processes. The laboratory uses an integrative approach that combines computational, informatics, and experimental brain imaging methods. A key area of focus is in linking the molecular level of organization to the neural systems and behavioral levels through the use of spatiotemporal profiles of gene expression coupled with brain imaging results, with the ultimate goal of better understanding genotype to phenotype relationships in neurodevelopmental disorders. Dr. Bohland is additionally involved in a collaborative experimental and informatics effort to comprehensively map the mesoscale connectivity patterns in the adult mouse brain.
Camron Bryant, Ph.D. (Assistant Professor, Departments of Pharmacology (BUMC) and Psychiatry) is the Director of the Laboratory of Addiction Genetics. His research program is focused on determining the genetic basis of behavioral and molecular traits relevant to substance dependence in mice. The ultimate goal is to improve our understanding of the neurobiological mechanisms of addiction and to translate these findings toward preventative and treatment strategies in humans. A current focus is to determine the genetic basis of the conditioned rewarding properties of opioids in mice by combining quantitative trait locus (QTL) analysis of behavior and gene expression in genetic reference populations that yield high resolution QTLs. This multi-pronged approach to gene mapping will accelerate the nomination of candidate genes for validation via direct gene targeting. Future plans include the development and application of a forward genetic analysis toward Pavlovian conditioning mouse models across a variety of conditions that are notoriously sensitive to the placebo effect, including pain, anxiety, depression, and Parkinson’s Disease.
Daniel Bullock, Ph.D. (Professor, Department of Psychology (CRC) (formerly Cognitive and Neural Systems) Interests of the Bullock lab are focused on the use of integrated computational models of local circuits implicated in reinforcement learning, planning of action sequences (including speech), and motivated decision making. Current models focus on forebrain circuits within or linking: laminar frontal cortex, the striatum and other parts of the basal ganglia, and midbrain dopaminergic areas. The long-term goal is construction of quantitative models of sufficient accuracy to predict effects of many pharmacological manipulations on decision-making, voluntary behavior, and skill learning.
Jerry Chen, Ph.D. (Assistant Professor, Department of Biology (CRC)). In the mammalian neocortex, long-range connections from one cortical area to another are essential for higher cognitive function. Dr. Chen is focused on dissecting the role of long-range networks in the neocortex during sensory-guided decision making by combining in vivo imaging technology with molecular and genetic tools in the awake-behaving animal. Using the mouse tactile whisker sensorimotor system as a model, the lab studies how long-range projection neurons function in lower- and higher-level cortical areas during tactile perception and how their organization is defined by genes and development. The lab has additional interests in developing new technologies for large-scale imaging of neuronal populations. These integrative approaches are applied with the hope of advancing our understanding of cortical function on a global and cellular level in the normal and disease state.
James Cherry, Ph.D. (Professor, Department of Psychology (CRC)) uses mouse models to understand the relationship between brain and behavior. The laboratory uses neuroanatomical, behavioral and electrophysiological techniques to characterize functional differences in the neural circuitry that processes socially relevant odors (pheromones), with the goal of defining the specific roles of the main and accessory olfactory pathways in pheromone detection. A second research area examines the role of type 4 phosphodiesterases in mechanisms underlying drug addiction and memory.
Pietro Cottone, Ph.D. (Assistant Professor, Department of Pharmacology and Experimental Therapeutics (BUMC)) is co-director of the Laboratory of Addictive Disorders. The research focus of the laboratory is the neurobiological substrates of motivated behaviors including feeding and addiction with the major goal of identifying the biological bases of and potential treatments for obesity and eating disorders. Current studies concern the role of stress in compulsive eating and palatable food dependence. Areas of focused research include the investigation of the neurobiological bases of stress-related disorders such as anxiety and depression. Dr. Cottone’s studies are carried out using environmental and genetic animal models, with behavioral, biochemical, and molecular approaches.
Alice Cronin-Golomb, Ph.D. (Professor, Department of Psychology (CRC)) directs the Vision & Cognition Laboratory whose principal focus is determining the factors that influence visual cognition in normal aging and age-related neurological disease. Her laboratory is identifying the brain bases of high-order cognitive dysfunction in neuropsychological populations, principally Alzheimer’s disease and Parkinson’s disease. Areas of interest in disease states include: (1) The relation between sensory function and cognitive function and (2) Neural circuitry of visuospatial function. Dr. Cronin-Golomb teaches courses in neuropsychology and in the psychology of aging.
Alberto Cruiz-Martin, Ph.D. (Assistant Professor, Department of Biology (CRC) A hallmark characteristic of sensory systems is that neurons in the periphery are tuned to detect specific features in our surroundings. As sensory information travels through the brain, downstream circuits combine it to generate richer more elaborate representations of the world. My current research aims to define the neural pathways that feed the visual system and at understanding how this information is parsed and later combined to create a percept of our world. Our long-term objective is to use the mouse visual system to bridge the gap between cellular and systems neuroscience to understand the contribution of specific cell types and their connections to visual processing and perception.
Ian Davison, Ph.D. (Assistant Professor, Department of Biology (CRC) The Davison lab aims to understand the neural basis of sensory perception, which they study using smell. Although natural odors often contain dozens of chemical components, detected by hundreds of different types of odorant receptors, odors are immediately experienced as a single percept. The goal is to understand the neural circuit computations the olfactory system uses to synthesize this information, a process that is central to our sensory experience. Olfactory learning is notoriously strong and rapid, and they are using smell as a window for understanding how experience is written into the brain’s internal structure. To test how networks of neurons recognize, store, and recall learned activity patterns, they combine quantitative behavior, electrophysiology, imaging, and optical manipulations of activity. Ultimately the hope is to use olfaction to help reveal some of the brain’s general mechanisms for flexible sensory processing, pattern recognition, and neural information storage.
Uri Eden, Ph.D. (Assistant Professor, Department of Mathematics (CRC)) focuses on developing mathematical and statistical methods to analyze neural spiking activity. He has worked to integrate methodologies related to model identification, statistical inference, signal processing, and stochastic estimation and control, and to expand these methodologies to incorporate point process observation models, making them more appropriate for modeling the dynamics of neural systems observed through spike train data. His research can be divided into two categories; first, a methodological component, focused on developing a statistical framework for relating neural activity to biological and behavioral signals and developing estimation algorithms, goodness-of-fit analyses, and mathematical theory that can be applied to any neural spiking system; second, an application component, wherein these methods are applied to spiking observations in real neural systems to dynamically model the spiking properties of individual neurons, to characterize how ensembles maintain representations of associated biological and behavioral signals, and to reconstruct these signals in real time.
Howard Eichenbaum, Ph.D. (Professor of Psychology and Pharmacology (CRC/BUMC)) The hippocampus plays a critical role in memory formation, but our understanding of just what the hippocampus does and how it performs its functions are still issues of considerable controversy. To enhance our knowledge about hippocampal function, the laboratory is pursuing a combination of neuropsychological studies of the nature of memory loss in animals with damage to the hippocampus and related cortical areas, and we are pursuing electrophysiological recording studies that seek to determine how information is represented by the hippocampus and associated cortical areas.
William Eldred, Ph.D. (Professor, Member of the GPN GEC, Department of Biology (CRC)) The laboratory studies nitric oxide (NO) that has normal physiological functions in every retinal cell type, and every retinal cell type can potentially make NO. NO is also involved in many ocular pathologies including diabetic retinopathy and inhibiting NO is often beneficial. NO signaling is regulated by many factors, both in normal retinal function and pathology, making it desirable to target just the pathological pathways. Research of the laboratory focuses on how NO can be selectively targeted to decrease the neuronal and vascular pathology in diabetic retinopathy. They are testing the following two hypotheses. 1) Diabetes increases the retinal levels of adrenomedullin (ADM), which in turn activates neuronal nitric oxide synthase (nNOS) to increase retinal NO production to pathological levels. These studies provide the first demonstration of the ADM/nNOS/NO signaling pathways in retina and their modulation in the neuronal and vascular pathology in diabetic retinopathy. 2) Neuronal and vascular pathology in diabetic retinopathy share similar molecular pathways and are amenable to similar pharmacological interventions. Their results will clarify the role of specific NOS isoforms and ADM in diabetic retinopathy and how these pathways can be optimally targeted to treat the pathology. Upregulation of ADM is also found in proliferative vitreoretinopathy, uveitis, vitreoretinal disorders, primary open angle glaucoma, and retinitis pigmentosa. A clearer understanding of the ADM/NOS/NO signaling pathways and how they can be manipulated in retina may have broad implications for much ocular pathology.
David H. Farb, Ph.D. (Professor and Chair, Department of Pharmacology and Experimental Therapeutics (BUMC)) focuses on the identification of pharmacological treatments for mental disorders of learning and memory. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers upon fundamental hippocampal systems for pattern separation (encoding), and pattern completion (retrieval) that are believed to be essential for cognition in all mammals, including man. Deficits in aspects of episodic memory dependent on hippocampal function are evident in a variety of mental disorders that have a huge social impact, including schizophrenia, autism, Alzheimer’s Disease, and normal aging. Existing pharmacotherapies for many such conditions are limited and carry substantial risk of adverse effects. High-density electrophysiological recordings in awake behaving rats are being used to identify deficits in hippocampal function that underlie cognitive deficits exhibited by aged animals and animals reared in social isolation, the latter being a model for environmental stress during development. A multidisciplinary approach that includes the techniques of neurophysiology, molecular biology, patch-clamp electrophysiology, cell biology, and molecular neuroanatomy are combined to elucidate the mechanisms and modalities of cognitive enhancers and the discovery of therapeutic treatments for disorders or diseases of the nervous system.
Lindsay A. Farrer, Ph.D. (Professor of Medicine, Neurology, Genetics & Genomics, Epidemiology, & Biostatistics; Chief, Genetics Program (BUMC)). Dr. Farrer’s research investigates genetic risk factors in familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing rare and common disorders including Alzheimer disease (AD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. In collaboration with researchers at other institutions, Dr. Farrer is conducting a genome scan to search for genes conveying susceptibility to cocaine and opioid dependence among families with multiple affected members.
Christopher Gabel, Ph.D. (Assistant Professor of Physiology & Biophysics and Pharmacology & Experimental Therapeutics) Dr. Gabel’s research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, Dr. Gebel can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows Dr. Gabel to tackle fundamental questions in neural regeneration and function.
Timothy Gardner, Ph.D. (Assistant Professor, Department of Biology (CRC)) studies how neural circuits form in the development of animal behavior. We focus on vocal learning in songbirds — a subject that lends itself to quantitative approaches. How do songbirds memorize the songs of other birds, and how do these memories influence their own vocal learning? Many songbirds sing fairly normally when reared in isolation, but in the right circumstances, they may also imitate external models. Song learning is therefore the result of innate programming that provides a basic outline for song, and an auditory-memory based learning that builds on the innate program. The laboratory is currently investigating the process that builds and maintains the core sequence of the song behavior. What growth mechanisms form the core structure of song and what are the geometric properties of the resulting circuit? What features of the circuit govern the flexible ordering of song? What homeostatic mechanisms maintain the circuit, and what is the role of spontaneous neural activity in sleep? For genetically identical birds, how would song learning differ? The lab is addressing one or more of these questions through tools including quantitative behavioral experiments and inbreeding, in-vivo imaging, electrophysiology and functional perturbation of neural activity.
Jeffery Gavornik, Ph.D.(Assistant Professor, Department of Biology (CRC)).The Gavornik lab studies how experience driven synaptic plasticity changes local neocortical physiology. Of particular interest is how neural circuits are able to incorporate past experience to predictively represent spatiotemporal information. Employing a variety of experimental and computational approaches, the lab examines how the cortical response to specific sensory stimuli change as a consequence of learning. The lab uses the primary sensory cortices, particularly the visual cortex, as relatively accessible and interpretable regions in which to isolate the core biology responsible for coding higher-order information in less accessible neocortical areas. The goal is to elucidate the mechanistic bases of cortical processing algorithms and memory storage.
Lee Goldstein, M.D., Ph.D. (Associate Professor, Departments of Psychiatry,Neurology, Ophthalmology, Pathology and Laboratory Medicine, & Biomedical Engineering (BUMC/CRC)) is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.
Stephen Grossberg, Ph.D. (Professor, Department of Cognitive Neural Systems (CRC)) develops brain models of vision and visual object recognition; audition, speech, and language; development; attentive learning and memory; cognitive information processing; reinforcement learning and motivation; cognitive-emotional interactions; navigation; sensory-motor control and robotics; and mental disorders. These models involve many parts of the brain, ranging from perception to action, and multiple levels of brain organization, ranging from individual spikes and their synchronization to cognition. He also collaborates in experimental projects to test predictions of his models, carrys out analyses of the mathematical dynamics of neural systems, and transfers biological neural models to applications in neuromorphic engineering and technology.
Frank Guenther, Ph.D. (Professor, Departments of Speech, Language, and Hearing Sciences (CRC)) combines theoretical modeling with behavioral and neuroimaging experiments to characterize the neural computations underlying speech and language. He is also involved in the development of speech prostheses that utilize brain-computer interfaces to restore synthetic speech to paralyzed individuals. The primary goal of the lab is to develop, test, and refine a computational modeling framework that addresses the neural processes underlying speech. This theoretical framework is applied to communication disorders and the design of neural prosthetics in collaborative projects with other labs within and outside of Boston University.
Xue Han, Ph.D. (Assistant Professor, Departments of Biomedical Engineering, Pharmacology and Experimental Therapeutics (CRC/BUMC)) Brain disorders represent the biggest unmet medical need, with many disorders being untreatable, and most treatments presenting serious side effects. The Han laboratory is discovering design principles for novel neuromodulation therapies. They invent and apply a variety of genetic, molecular, pharmacological, optical, and electrical tools to correct neural circuits that go awry within the brain. As an example, they have pioneered several technologies for silencing specific cells in the brain using pulses of light. They have also recently participated in the first pre-clinical testing of a novel neurotechnology, optical neural modulation. Using these novel neurotechnologies and classical ones such as deep brain stimulation (DBS), they modulate the function of neural circuits to establish causal links between neural dynamics and behavioral phenomena (e.g., movement, attention, memory, and decision making). One of their current interests is the investigation of how neural synchrony arises within and across brain regions, and how synchronous activity contributes to normal cognition and pathology.
David Harris, M.D., Ph.D. (Professor and Chair, Department of Biochemistry (BUMC)) The Harris laboratory studies prion diseases, including Creutzfeldt-Jakob disease and kuru, that are fatal neurodegenerative disorders now of great medical importance because of the emergence of “mad cow disease” in Europe and the U.S., and its likely transmission to human beings. These diseases are also of enormous scientific interest because they involve an entirely novel mechanism of biological information transfer: they result from a change in the conformation of an endogenous membrane glycoprotein (PrPC) that converts it into a pathogenic isoform (PrPSc) that is infectious in the complete absence of nucleic acid. To address this field, the laboratory utilizes several experimental systems including yeast, cultured mammalian cells, and transgenic mice. They employ a wide range of techniques, including cell labeling, protein chemistry, light and electron microscopy, proteomics, DNA microarray analysis, mouse genetics, neuropathology, and animal bioassays.
Michael Hasselmo, Ph.D. (Professor, Department of Psychology (CRC)) Research in the Hasselmo laboratory is concerned with the cortical dynamics of memory-guided behavior, including effects of neuromodulatory receptors and the role of theta rhythm oscillations in cortical function. Neurophysiological techniques are used to analyze intrinsic and synaptic properties of cortical circuits in the rat, and to explore the effects of modulators on these properties. Computational modeling is used to link this physiological data to memory-guided behavior. Experiments using multiple single-unit recording in behavioral tasks are designed to test predictions of the computational models. Areas of focused research include episodic memory function and theta rhythm dynamics in the entorhinal cortex, prefrontal cortex and hippocampal formation. Research addresses physiological effects relevant to Alzheimer’s disease, schizophrenia and depression.
Tarik Haydar, Ph.D. (Associate Professor, Department of Anatomy and Neurobiology (BUMC)) The Haydar Laboratory of Neural Development and Intellectual Disorders uses a molecular neuroscience approach to study mammalian brain development, specifically focusing on the neural stem cells and precursors in the neocortex and hippocampus. The lab also investigates the cellular and genetic mechanisms of developmental disorders including those underlying mental retardation in Down syndrome using state of the art techniques such as in utero electroporation, in vivo genetic fate mapping and cell ablation.
Angela Ho, Ph.D. (Assistant Professor, Department of Biology (CRC)) The focus of the Ho lab’s research is to study cellular and molecular pathways involved in Alzheimer’s pathogenesis. They examine Alzheimer’s related proteins by integrating mouse genetics with biochemical and cell biological approaches to address the physiological function and pathological processes that lead to neurodegeneration in the AD brain. One of the pathological hallmarks of AD is the formation of extracellular neuritic plaques containing deposits of 40-43 amino acid amyloid peptides that are derived from the parent amyloid precursor protein (APP). To date, the normal biological function of the APP gene family remains unclear. They are investigating the role of the APP gene family in development, specifically on synaptic function and learning, and more importantly, their native function in the adult brain. The second interest of the lab focuses on an essential family of neuronal adaptor proteins named Mint/X11s that have been implicated in coupling synaptic functions to the regulation of amyloidogenic processing of APP.
Marc Howard, Ph.D. (Associate Professor, Department of Psychology (CRC)). Memory is intimately linked with our experience of the passage of time. We work to develop mathematical models that describe how the brain represents the past and predicts the future. These hypotheses are tested against behavioral results on the one hand, and neurophysiological findings, on the other. Behavioral experiments test our ability to explain interval timing, episodic memory, and conditioning results. Collaborative work with cognitive neuroscientists and systems neurophysiologists test our ability to explain neural data at the ensemble and single unit level. Computational simulations test our ability to explain the development of large-scale meaning networks in semantic memory and language.
Tsuneya Ikezu, M.D., Ph.D. (Professor of Pharmacology & Experimental Therapeutics and Neurology (BUMC)) The Ikezu Laboratory of Molecular NeuroTherapeutics primarily focuses on Neuroimmunology and how the innate immune-related molecules in the central nervous system (CNS) influences the pathology and progression of select neurodegenerative disorders e.g. Alzheimer’s Disease (AD). The lab also investigates pharmacological means to suppress the innate immune response in the CNS with the goal of enhancing neuronal protection and minimizing collateral damage from an activated immune response in the CNS. Specifically they are investigating the role of the signaling cytokine IL-4/10/CD200 and its potential anti-inflammatory/neuroprotective role between microglia and both neurons and astrocytes during active CNS inflammation. Further, they are exploring IL-4/10/CD200 as a potential therapeutic in chronic inflammatory states within the CNS, such as seen in Alzheimer’s disease, to minimize neuronal cell loss. A second focus of the Ikezu lab is the investigation of tau-tubulin kinases (TTBK1 and 2) and their role in hyper-phosporylating tau protein leading to the formation of tau and alpha-synuclein tangles within neurons, a key pathology observed in AD, Amyotrophic lateral sclerosis (ALS)/Lou Gehrig’s Disease, Spinocerebellar Ataxia, and Frontotemporal Dementia (FTD).
Kathleen Kantak, Ph.D. (Professor, Member of the GPN GEC, Department of Psychology (CRC)) uses animal models to conduct translational research related to drug addiction, attention deficit hyperactivity disorder and their co-morbidity. Using intravenous drug self-administration procedures in rats, they investigate how multiple memory systems regulate drug-seeking and drug-taking behavior as well as how drug exposure influences the neurocognitive functioning of multiple memory systems. In addition, they investigate how cognitive-enhancing therapeutics may be useful to facilitate extinction learning for drug-conditioned cues and attenuate drug relapse. Other studies focus on evaluating the frontostriatal and medial temporal lobe neurocognitive deficits in rats with an ADHD phenotype and their response to medications as well as comorbidity between ADHD and vulnerability to drug addiction. In the context of all this research, Kantak collaborates with other investigators to conduct image analysis or to understand the neurochemical and molecular correlates of these disorders and their treatment.
Gary Kaplan, M.D. (Professor, Departments of Psychiatry and Pharmacology and Experimental Therapeutics (BUMC)) Addiction can be conceptualized as a progressive phenomenon initiated and maintained by the conditioned rewarding effects of drugs of abuse. As a result of neural plasticity in motivational and cognitive circuits, exposure to drug cues previously can evoke drug craving and seeking responses and that can reinstate drug taking. Our research examines the effects of gamma-aminobutyric acid- (GABA) type B and N-methyl-D-aspartate receptor receptor agents on the acquisition and expression of opiate and cocaine reward, self-administration, their extinction, and reacquisition. Such research defines the mechanisms related to drug relapse and defines novel therapeutic targets of interest for clinical studies. We utilize state-of-the-art methods in behavioral neuroscience, neuroanatomy, and neurochemistry to study these signaling pathways and circuitry in addiction and PTSD.
Swathi Kiran, Ph.D. (Professor, Speech Language and Hearing Sciences (CRC)) studies the development of various rehabilitation approaches and mechanisms of neural plasticity in individuals with post-stroke aphasia. Her research examines neuroimaging, structural and functional connectivity analyses after rehabilitation in monolingual and bi/lingual individuals with aphasia. These studies examine left hemisphere undamaged regions of the cortex as potential regions within the language network that are engaged in the service of language recovery. She is also interested in identifying predictors of language recovery after rehabilitation and uses computational modeling to simulate and predict treatment outcomes in patients with bilingual aphasia. She is also interested in identifying predictors of language recovery after rehabilitation and uses computational modeling to simulate and predict treatment outcomes in patients with bilingual aphasia. Dr. Kiran is a fellow of the American Speech Language and Hearing Association and serves on multiple editorial boards.
Nancy Kopell, Ph.D. (Professor, Member of the GPN GEC & Computational Neuroscience Curriculum Committee, Department of Mathematics (CRC), National Academy of Sciences) is interested in the dynamics of cortical electrical activity associated with sensory processing, cognition and motor control. This broad area includes 1) the physiological and anatomical bases of the multiple rhythms measured in EEG, MEG and invasive paradigms; 2) the relationships between those rhythms and cognitive function; 3) how pathologies in those rhythms relate to cognitive and motor symptoms in neurological diseases. Dr. Kopell is the currently co-director of the Center for BioDynamics (CBD) in the College of Engineering at Boston University. This multidisciplinary, interdepartmental center aims to train undergraduates, graduates, and postdoctoral fellows in leading techniques from dynamical systems theory and its applications to biology and engineering.
Mark Kramer, Ph.D. (Assistant Professor, Department of Mathematics (CRC)) focuses his research on topics in mathematical neuroscience, with particular emphasis on neural rhythms, dynamical systems, data analysis, and brain disease. The work is highly interdisciplinary, involving mathematicians, statisticians, neuroscientists and clinical collaborators. He is especially interested in the quantitative analysis of electrophysiological data, and understanding the biophysical mechanisms that produce the dynamic neural activity observed. His current clinical work focuses on analyzing multivariate data and identifying the mechanisms that support the pathological brain activity characteristic of epilepsy.
Susan E. Leeman, Ph.D. (Professor, Department of Pharmacology and Experimental Therapeutics (BUMC)) Dr. Leeman’s work focuses on the two peptides, substance P (SP) and neurotensin, which were isolated and chemically defined in her laboratory and lead to her membership in the National Academy of Sciences. Projects that are currently underway include: 1. the role of glycosylation of the NK1 receptor on its signal transduction pathways, 2. the roles of SP in several models of inflammation in the gastrointestinal tract, including post-surgical cell adhesion formation, and the effect of non-peptide SP antagonists. 3. the role of LITAF, a newly described transcription factor participating in TNF alpha synthesis in macrophages obtained from inflamed colonic tissue.
Jen-Wei Lin, Ph.D. (Professor, Departments of Biology and Pharmacology and Experimental Therapeutics (CRC/BUMC)) focuses on cellular and molecular mechanisms of neurotransmitter secretion Neurotransmitter secretion is a complicated process that involves ion channel gating and secretion steps. In addition, the mobilization and recycling of synaptic vesicles are needed to maintain the function of a synapse and to contribute to synaptic plasticity. Ultimately, an understanding of the secretory events means that one can establish a kinetic scheme for this multi-step process and identify molecules responsible for each step. Therefore, a combined electrophysiological and molecular approach is used in the Wei-Lin laboratory to investigate these questions.
Sam Ling, Ph.D. (Assistant Professor, Department of Psychology, CRC) focuses on cognitive processes such as attention, learning and awareness, and how these processes transform incoming sensory signals into a cohesive perceptual experience. In particular, work in the lab aims to characterize the mechanisms that underlie changes in basic cortical and subcortical response properties, such as neural responsivity, selectivity and variability. Research in the Ling lab combines a variety of techniques, including psychophysics, computational modeling, transcranial magnetic stimulation (TMS), and functional magnetic resonance imaging (fMRI) –all aimed towards understanding how the human brain mediates between the “buzzing confusion” of the visual world and its limited processing power.
Jennifer Luebke, Ph.D. (Associate Professor, Department of Anatomy and Neurobiology (BUMC)) employs whole-cell patch-clamp and intracellular filling techniques to examine the electrophysiological and morphological properties of neurons in in vitro slices of monkey and mouse neocortex. Research is focused on action potential firing patterns (and underlying ionic currents), glutamatergic and GABAergic synaptic response properties and detailed dendritic architecture. Data from single neurons are incorporated into computational models in collaboration with mathematicians at Mt. Sinai School of Medicine. In addition, collaborations are ongoing with investigators at BUSM who use molecular biological (single cell PCR and microarray) and electron microscopic (ultrastructural analysis) techniques to examine cells from which recordings are obtained. Overall goals include: 1) to examine the individual and network properties of cells in the prefrontal cortex; 2) to determine the effects of normal aging on these properties in the rhesus monkey, and; 3) to determine the effects of amyloid and tau on these properties in transgenic mouse models of Alzheimer’s disease.
Hengye Man, Ph.D. (Assistant Professor, Departments of Biology and Pharmacology and Experimental Therapeutics (CRC/BUMC)) is interested in the mechanisms in the expression of synaptic plasticity. Since most of synaptic transmission is mediated by glutamatergic AMPA receptors, the studies have been focused on regulation of AMPA receptor expression, turnover and synaptic localization as well as synaptogenesis. The questions they address include: What molecules and signaling pathways determine AMPAR synaptic localization? How does neuronal activity regulate AMPA receptor trafficking and expression? How does the neuron maintain a specific amount of total receptors? How are receptors degraded and what regulates the rate of turnover? Using cultured cortical and hippocampal neurons and brain slices, we study receptor trafficking and synaptic transmission by employing a wide range of techniques including immunocytochemistry, confocal/fluorescence microscopy, live-imaging, biochemistry (western blotting, immunoprecipitation), and electrophysiology (patch clamp recording).
Joe McGuire, Ph.D. (Assistant Professor, Department of Psychological & Brain Sciences, CRC) studies value-based decision making in humans. Work in the lab seeks to describe the information-processing operations that facilitate subjective evaluations and decisions in complex and challenging environments. We use a variety of methods including behavioral experiments, quantitative modeling, and functional neuroimaging. Key research topics include persistence and delay-of-gratification under uncertainty, learning and belief updating, and flexible neural representations of subjective value and reward.
Mark Moss, Ph.D. (Professor and Chairman, Department of Anatomy and Neurobiology (BUMC)) studies the neurobiological basis of successful and unsuccessful aging, with particular respect to memory and executive functions. Specific interests include (1) the interaction of the prefrontal cortices with the medial temporal lobe limbic system in cognition; (2) the separate and combined effects of age and hypertension on cognition and integrity of the blood-brain barrier in a non-human primate model of hypertensive cerebrovascular disease and (3) parallel studies in normal aged humans and patients with MCI and Alzheimer’s disease. Techniques include automated behavioral assessment, functional and structural MR imaging, and an array of immunocytochemical and related anatomical-morphological techniques.
Marlene Oscar-Berman, Ph.D. (Professor, Member of the GPN GEC, Departments of Anatomy and Neurobiology, Psychiatry, and Neurology (BUMC)) explores the brain and behavioral consequences of human neurological disorders. Her recent publications are on the cognitive and emotional changes that result from chronic alcoholism, as well as on brain structural changes that are apparent in regions involved in cognitive and emotional functioning. Dr. Berman also has studied the behavioral consequences of brain damage in patients with other disorders of the central nervous system. Additionally, her work on brain asymmetries addresses questions concerning the different roles of the two cerebral hemispheres in processing, understanding, and responding to visual information having emotional and non-emotional content. Dr. Berman is the recipient of numerous awards, including a Fulbright award and a Senior Scientist and Mentorship award from the National Institute on Alcohol Abuse and Alcoholism in the National Institutes of Health.
Tyler Perrachione, Ph.D, (Assistant Professor. Department of Speech, Language, and Hearing Sciences) is the director of the Communication Neuroscience Research Laboratory. Dr. Perrachione’s research explores how the structure and function of the human brain supports a capacity for complex communication, including speech perception, language learning, and voice recognition. The lab approaches these questions through a systems neuroscience framework, investigating how fundamental neural processes such as auditory plasticity underlie communication development and expertise. This basic science approach supports a clinical research emphasis on understanding the neural profile of developmental communication disorders such as dyslexia and language-based learning impairments. The laboratory employs a wide array of contemporary neuroimaging technologies, including structural and functional MRI, EEG, and noninvasive neurostimulation for research on human participants.
Jason Ritt, Ph.D. (Assistant Professor, Biomedical Engineering) Dr. Ritt’s research concentrates on how organisms gather and use information from their environment, through processes of active sensing and sensory decision making. Current projects employ electrophysiological, behavioral, optogenetic and theoretical methods applied to the rodent whisker system, a highly refined tactile sensory system. Experiments combine multi-electrode recording of brain activity; high speed videography of behavior and development of automated image analysis algorithms; and optical stimulation of specific cell types (e.g., excitatory vs. inhibitory neurons) using genetically targeted expression of light sensitive ion channels. Parallel modeling uses tools from dynamical systems, control theory and decision theory. Augmenting experiments with model-driven, real-time feedback forms a basis for development of brain machine interfaces, with an emphasis on sensory neural prosthetics, in addition to providing state of the art tools to address basic questions of neural function.
Douglas Rosene, Ph.D. (Professor, Member of the GPN GEC, Course Director for GPN, Department of Anatomy and Neurobiology (BUMC)) The research of Dr. Rosene focuses on identifying the neurobiological basis of learning and memory and related higher cognitive functions in the normal brain and the basis of disruption of these processes in various neurodegenerative diseases and forms of neurological damage. The laboratory employs multidisciplinary methods to investigate these issues in the rhesus monkey model of cognitive function. Methods include combinations of behavioral, neurohistochemical, neurophysiological, neuroanatomical, neurosurgical, and MRI techniques. Investigations supported by the Program Project that he directs, seeks to identify the neurobiological basis of age-related impairments in learning, memory and executive function in the rhesus monkey model of normal aging. Results of these investigations have demonstrated that cortical neurons are not lost in normal aging as conventional wisdom held but instead the main changes are in the subcortical white matter of the forebrain. Parallel studies are focused on neurodegenerative disease, cerebrovascular disease and traumatic brain injury, and in collaboration with Dr. H. Eugene Stanley in the Physics Dept at BU the development of novel ways to quantify the microcolumnar structure of cerebral cortex using methods from statistical physics.
Michele Rucci, Ph.D. (Associate Professor, Departments of Psychology and Biomedical Engineering (CRC)) directs The Active Perception Lab that focuses on active perception in biological and artificial systems. Experimental and theoretical approaches are combined to examine motor influences on perceptual performance and on the encoding of sensory information in the brain. Robots replicating the sensory-motor strategies of various species are studied in an effort to develop efficient machine perception systems. Research in the Active Perception Laboratory has raised specific hypotheses regarding the influences of eye movements during visual development and in the neural encoding of visual information. This research has also demonstrated the involvement of fixational eye movements in fine spatial vision, produced a new system for experimental studies of visual neuroscience, and led to the development of robots directly controlled by models of the brain.
Shelley Russek, Ph.D. (Professor of Pharmacology and Biology, Director of GPN (BUMC and CRC)). The research of Dr. Russek focuses on the role of BDNF in brain plasticity of neural networks and in multiple neurologic and neuropsychiatric disorders, such as anxiety, epilepsy, autism, depression and schizophrenia. It is clear that BDNF plays a crucial role in organizing the response of the genome to dynamic changes in the extracellular environment that enable brain plasticity and it has emerged as one of the most important signaling molecules of diverse intracellular programs that maintain a healthy balance of excitation and inhibition in the brain. How BDNF transcriptionally controls the pool of important proteins that are the substrate of this balance in vivo, increasing as well as decreasing the number and kind of key proteins and enzymes, is not understood and is a major question of the Russek laboratory. How BDNF controlled gene networks in individual neurons may impact the dynamics of a neural circuit both in healthy and diseased individuals, is also a major question of her research that employs a variety of techniques in molecular and systems neuroscience.
Valentina Sabino, Ph.D. (Assistant Professor, Department of Pharmacology and Experimental Therapeutics (BUMC)) is co-director of the Laboratory of Addictive Disorders. Dr. Sabino is currently researching the neurobiology of addiction and stress-related disorders. Studies on addiction aim to understand the neurobiological substrates of alcohol abuse and dependence, by exploring the role of central neurochemical systems in excessive alcohol drinking. She is working toward the development of new therapeutic agents to alleviate alcohol addiction. Animal models for excessive drinking are studied in order to identify compounds for potential clinical development. Research is also conducted on the neurobiology of stress-related disorders such as anxiety and depression. The laboratory uses environmental and genetic animal models of disease, with a multidisciplinary approach to understand the neurobiology of psychiatric disorders and to develop novel therapies.
Barbara Shinn-Cunningham, Ph.D. (Professor, Director of CompNet, Department of Biomedical Engineering (CRC)) Shinn-Cunningham is the Director of the Auditory Neuroscience Laboratory in the Boston University Hearing Research Center, housed in the Department of Cognitive and Neural Systems. Projects in the Auditory Neuroscience Laboratory explore how we perceive sound sources in ordinary listening environments that contain multiple, competing sources, echoes, and reverberation. They are investigating how auditory attention and the perceptual organization of sound influences perception, how the brain encodes features of sound important for perception (including spatial auditory cues), the role of multimodal interactions in perception, and development of physiologically based computational models of auditory processing. A variety of methods are employed, including psychophysics, modeling, EEG, acoustical measurement, and single-unit recording.
Jean-Jacques R. Soghomonian, Ph.D. (Associate Professor, Department of Anatomy and Neurobiology (BUMC)) The laboratory focuses on the functional and chemical neuroanatomy of the basal ganglia and the cerebral cortex in normal animals and in experimental models of Parkinson disease. Current objectives are to study the plasticity of GABA-mediated signaling in the basal ganglia and cerebral cortex and the mechanisms involved in motor and cognitive disorders in Parkinson disease in a 6-hydroxydopamine-rodent model of Parkinson’s disease and on human brains. The research involves behavioral and biochemical/molecular approaches including analysis of gene expression by in situ hybridization histochemistry and computerized quantitative image analysis, immunohistochemistry, western-blotting and in vivo microdialysis combined with HPLC.
David Somers, Ph.D. (Professor, Academic Director of GPN/Computational Specialization, Department of Psychology (CRC)) heads the Perceptual Neuroimaging Laboratory that investigates the neural and cognitive representations and mechanisms of perception, attention, and perceptual short-term memory in humans using functional magnetic resonance imaging, computational modeling and psychophysics. In addition to the primary focus on vision, collaborative work investigates tactile and auditory processing. Functional MRI studies focus on within-subject data analysis that permits the functional segregation of small cerebral cortical areas that are often obscured in across-subject analysis. Recently, they identified and characterized two new visuotopic areas in human posterior parietal cortex using these methods.
Cara E. Stepp, Ph.D. (Assistant Professor, Departments of Speech, Language, and Hearing Sciences and Biomedical Engineering (CRC)) is head of the STEPP LAB for Sensorimotor Rehabilitation Engineering. The lab combines neural, electrical, and mechanical engineering to investigate sensorimotor disorders, with the goal of rehabilitating disordered movement. Members study normal and disordered speech and voice with the long-term research goal of extending therapeutic advances to the speech system. Research exploits multimodal sensory feedback and virtual reality to develop novel human-machine-interfaces for communication.
Chantal Stern, Ph.D. (Professor, Department of Psychology (CRC)) is a core faculty member of the Conte Center for Memory and Brain, a member of the NSF CELEST Science of Learning Center, and a faculty member at the Martinos Center for Biomedical Imaging at the Massachusetts General Hospital. She also serves as an internal advisory board member for the Boston University Alzheimer’s Disease Center. Her students are trained in basic fMRI research methodology, and in addition are trained either to link their fMRI work to animal and computational models (integration with Hasselmo and Eichenbaum labs) or to link their studies with clinical population studies (Alzheimer’s disease, Parkinson’s disease, HIV dementia, eating disorders). Chantal Stern has been instrumental in providing fMRI training to postdocs and graduate students that were initially trained in other research methodologies, including students and postdocs initially trained in ERP methods; optical animal imaging methods, animal lesion and electrophysiological methods, clinical neuropsychology methods, and structural and morphometric imaging method.
Helen Tager-Flusberg, Ph.D. (Professor, Departments of Psychology (CRC) & Anatomy and Neurobiology (BUMC)) is the Director of the Lab of Developmental Cognitive Neuroscience at Boston University/BU School of Medicine. For the past three decades she has investigated the cognitive architecture that characterizes children with different neurodevelopmental disorders, including autism spectrum disorders, Williams syndrome, specific language impairment and other genetically-based disorders, with a particular focus on language and social cognition. Her work emphasizes the integral connection between typical and atypical development exploring how data from children with neurodevelopmental disorders may illuminate theoretical issues of normal development.
Lucia Vaina, M.D., Ph.D. (Professor, Department of Biomedical Engineering (CRC)) The adult brain constantly adapts to changes in stimuli, and this plasticity is manifest not only as learning and memory but also as dynamic changes in information transmission and processing. The goal of research in the Brain and Vision Research Laboratory is to understand the mechanisms mediating human visual perception in healthy and damaged human brain, long-term plasticity and short-term dynamics in networks of the adult normal and damaged (from stroke) cortex by using interactively multimodal imaging (fMRI, MEG, DTI), psychophysics, and biologically constrained computational modeling. An additional facet of our research is translational, conducted hand in hand with several neurologists and psychiatrist clinicians, that investigates multisensory processing for facilitating behavior and recovery in stroke patients.
John A. White, Ph.D. (Professor and Chair of Biomedical Engineering (CRC)) The White laboratory uses engineering approaches to understand how information is processed in the brain, with the goal of exploiting these findings to improve the human condition. Methods include: electrophysiological and imaging techniques for recording detailed information from single neurons and large neuronal networks; computational modeling of neuronal networks; and design and construction of instruments that interact with human subjects and biological preparations in real time at high clock speeds.
Benjamin Wolozin, M.D., Ph.D. (Professor of Pharmacology and Experimental Therapeutics (BUMC)) is interested in the pathophysiology of neurodegenerative diseases focusing on the biology of proteins that accumulate as aggregates or regulate aggregation. For Parkinson’s disease they study alpha-synuclein and LRRK2. For work on amyotrophic lateral sclerosis they study TDP-43. Alzheimer research focuses on beta-amyloid, cholesterol and SORL1. The approaches used include cell and molecular biology, signal transduction, neurotoxicity, apoptosis and neuroprotection. Models include C. elegans, cell lines, primary neuronal cultures and pathological human tissues.
Irina Zhadanova, Ph.D. (Professor of Anatomy and Neurobiology (BUMC)). Research interests in the Zhdanova laboratory center around the role of endogenous factors secreted into the cerebrospinal fluid in regulating behavior and physiological functions. They are specifically interested in two secretory organs, the pineal gland and the subcommissural organ (SCO), both of which secrete into the third brain ventricle, as well as into the blood stream. Dr. Zhdanova is studying the role of circadian system in development and aging, and an impact of circadian factors on the effects of drugs of abuse. The studies in her laboratory employ non-human primates and zebrafish.
Basilis (Vasileios) Zikopoulos, Ph.D. (Assistant Professor of Health Sciences (CRC)). The Human Systems Neuroscience Laboratory focuses on the study of the organization and dynamics of cortical brain circuits, and their disruption in disease. Increasingly, their work has been focusing on processes that shape network dynamics and the delicate balance of excitation and inhibition, which are consistently disrupted in autism and other neurodevelopmental disorders. They use advanced experimental and computational approaches to image and study molecular, synaptic, cellular interactions and interareal network connectivity, as the basis of cognitive and emotional processing for flexible attention and goal-oriented behavior in humans, non-human primates and other relevant animal model systems. Their innovative multi-disciplinary approach includes correlated light, confocal and electron microscopy; and large-scale, and thus far unprecedented, three-dimensional analysis and reconstruction of labeled pathways and their synaptic and neurochemical interactions within functionally-distinct networks. These cutting-edge, high-resolution experimental approaches, complemented by advanced computational and image analysis techniques, have made it possible to conduct detailed quantitative analyses and develop brain-based circuit and computational models, describing novel circuits that have a key role in cognitive and emotional processes.