COURSE
OFFERINGS BY COLLEGE
The following Neuroscience courses
offered at Boston University are organized by approach:
COURSES WITH
AN EXPERIMENTAL EMPHASIS:
ANATOMY and NEUROBIOLOGY (MED)
AN 702 – Neurobiology of Learning and Memory
AN 707 – Neurobiology of Aging
AN 709 – Neural Development and Plasticity (2 cr)
AN 718- Methods in Neuroscience
AN 804 – Special Topics: History of Neuroscience (2 cr)
AN 808 – Neuroanatomical Basis of Neurological Disorders (2 cr)
BEHAVIORAL NEUROSCIENCE (MED)
BN 775 – Human Neuropsychology I
BN 776 – Human Neuropsychology II
BN 796 – Neuropsychological Assessment I
BN 798 – Functional Neuroanatomy in Neuropsychology
BN 793 – Neuropsychology of Language
BN 795 – Neuropsychology of Perception & Memory
BN 797 – Neuropsychological Assessment II
BIOCHEMISTRY (MED)
MS 783 – Molecular Basis of Neurologic Diseases I
MS 784 – Molecular Basis of Neurologic Diseases II
BIOLOGY (CAS)
BI 545 – Neurobiology of Motivated Behavior
BI 554 – Neuroendocrinology
BI 575 – Techniques in Cellular and Molecular Neurosphysiology
BI 607 – Animal Behavior
BI 644 – Neuroethology
BI 645 – Cellular and Molecular Neurophysiology
BI 655 – Developmental Neurobiology
BI 663 – Chemosensory Biology
BI 676 – Neurobiology/Biophysics
BI 681 – Neurochemistry
HEALTH SCIENCES (SAR)
HS 550 – Neural Systems
HS 582 – Neuroanatomy & Neurophysiology
HS 755 – Readings in Neuroscience
PHARMACOLOGY and EXPERIMENTAL THERAPEUTICS (MED)
PM 700 – Molecular Neurobiology & Pharmacology
PM 820 – Behavioral Pharmacology
PM 840 – Neuroendocrine Pharmacology
PM 860 – Electrophysiology & Pharmacology of the Synapse
PSYCHOLOGY (CAS)
PS 530 – Neural Models of Memory Function
PS 538 – Human Brain Mapping
PS 544 – Developmental Neuropsychology
PS 573 – Abstract Thought
PS 721A – Experimental Psychology: Molecular Genetics in
Neurobiology and Behavior
PS 721B – Experimental Psychology: Neurobiology of Learning
PS 734 – Psychopharmacology
PS 735 – Concepts of Motivation
PS 737 – Memory Systems of the Brain
PS 821 – Learning
PS 822 – Visual Perception
PS 829 – Clinical Neuropsychology
PS 831 – Seminar in Neuropsychology (2 credits)
PS 832 – Physiological Psychology
PS 833 – Advanced Physiological Psychology
COURSES
WITH A COMPUTATIONAL EMPHASIS:
COGNITIVE and NEURAL SYSTEMS (CAS)
CN 500 – Computational Methods in Cognitive and Neural Systems
CN 510- Principles and Methods of Cognitive and Neural Modeling I
CN 520 – Principles and Methods of Cognitive & Neural Modeling II
CN 530 – Neural and Computational Models of Vision
CN 540 – Neural and Computational Models of Adaptive Movement
Planning and Control
CN 550 – Neural & Computational Models of Recognition,
Memory, and Attention
CN 560 – Neural & Computational Models of Speech Perception and
Production
CN 570 – Neural & Computational Models of Conditioning,
Reinforcement, Motivation, and Rhythm
CN 580- Introduction to Computational Neuroscience
CN 700 – Computational and Mathematical Methods in Neural Modeling
CN 710 – Advanced Topics in Neural Modeling
CN 720 – Neural and Computational Models of Planning and
Temporal Structure in Behavior
CN 730 – Models of Visual Perception
CN 740 – Topics in Sensory Motor Control
CN 760 – Topics in Speech Perception & Recognition
CN 780 – Topics in Computational Neuroscience
CN 810 – Topics in Cognitive & Neural Systems
CN 811 – Topics in Cognitive & Neural Systems: Visual Perception
MATHEMATICS (CAS)
MA 555 – Numerical Analysis, I
MA 573 – Introduction to the Qualitative Theory of Ordinary
Differential Equations
MA 574 – Applied Nonlinear Dynamics
MA 771 – Introduction to Dynamical Systems
COURSES
WITH AN EXPERIMENTAL AND
COMPUTATIONAL EMPHASIS:
BIOMEDICAL ENGINEERING (ENG)
BE 515 – Introduction to Medical Imaging
BE 516 – Applied Medical Imaging (Summer term)
BE 540 – Bioelectric Signals: Analysis and Interpretation
BE 550 – Bioelectromechanics
BE 570 – Introduction to Computational Vision
BE 701 – Auditory Signal Processing: Peripheral
BE 702 – Auditory Signal Processing: Central
BE 707 Quantitative Studies of Excitable Cells
BE 710 – Neural Plasticity and Perceptual Learning
BE 715 – Functional Neuroimaging
EK 760 – Intelligent Systems
COURSE DESCRIPTIONS
BY DEPARTMENT
(some course descriptions may not be available)
Click on any heading for course descriptions organized
by department.
DEPARTMENT
OF ANATOMY AND NEUROBIOLOGY
(School of Medicine)
MED AN 702 Neurobiology of Learning and Memory
This course covers the neurobiological
bases of learning and memory from the cellular to the systems level.
Initial sessions cover the behavioral aspects of learning and memory
– how
it is operationally defined and what are the different theoretical
concepts from cognitive psychology that are current. Subsequent
sessions investigate the neurophysiological, neuroanatomical, and
neurochemical mechanisms of memory at the cellular level and then
move on to the study of systems that function at the level of the
whole organism. Concentration is on studies in mammals, particularly
primates.
MED AN 707 Neurobiology of Aging
With growing awareness of an accelerating increase in the size of
the elderly population, there has been increasing interest in the
neuropsychology of normal aging. Similarly, since aging is a major
risk-factor for many dementia states, interest has also focused
on the neuropsychology of age-related disorders such as Alzheimer's
disease, Parkinson's disease, and the Dementias of the frontal lobe
type. This course attempts to summarize what is known about cognitive
and related changes associated with normal aging and age-related
disease. The course is divided into four major sections. The first
considers the cognitive changes associated with normal aging; the
second deals with the most common causes of cognitive decline seen
in the elderly; the third reviews the current data concerning neuroimaging
in aging and dementia; and the fourth part covers future directions
in the study of normal aging.
MED AN 709 Neural Development and Plasticity (2 cr)
This course consists of lectures, discussion, and readings on current
issues relating to neural changes during development and how the
nervous system is modified by interaction of the organism with the
environment, and how the nervous system responds to injury. Emphasis
is on cellular and systems levels of organization.
MED AN 718 Methods in Neuroscience (4cr.)
Preq: Systems Neuroscience and consent of instructor. This course will provide a general overview of major techniques and methods used in contemporary neuroscience research. It is designed to provide students with knowledge to understand methods to probe the brain from molecules to behavior. 4 cr, 2nd sem.
MED AN 804 Special Topics: History of Neuroscience (2 cr)
MED AN 808 Neuroanatomical Basis of Neurological Disorders
(2 cr)
Localization of specific anatomical changes in the brain in such
disorders as autism, dyslexia, schizophrenia, olivopontocerebellar
atrophy, and selected neurodegenerative diseases such as Alzheimer's
and ALS. Developmental mechanisms leading to neuroanatomical alterations
are discussed when appropriate. Lectures, discussions of classical
and current literature, and guest speakers.
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DEPARTMENT
OF BEHAVIORAL NEUROBIOLOGY
(School of Medicine)
MED BN 775 Human Neuropsychology I
Relationship of the field of neuropsychology to other medical and
scientific disciplines. Includes electrical activity of the brain,
the study of consciousness and emotions, cerebral dominance, and
the pathologies of language.
MED BN 776 Human Neuropsychology II
Relationship of the field of neuropsychology to other medical and
scientific disciplines. Includes psychiatric aspects of neurological
disease and the pathologies of memory, intelligence, perception,
and motor function.
MED BN 796 Neuropsychological Assessment I
Overview of structure and function of the central nervous system.
Emphasis on quantitative and qualitative analyses of standardized
and experimental tests of cognitive functions useful in differential
diagnosis of neurological syndromes.
MED BN 798 Functional Neuroanatomy in Neuropsychology
Overview of central nervous system, structure and function; basic
understanding of neurobehavioral symptoms and their relationship
to neuropathology, including vascular infections, and congenital,
degenerative, and toxic insults to the central nervous system. Appropriate
for psychologists, speech pathologists, or other students in the
behavioral sciences.
MED BN 793 Adult Neurologic Communication Disorders
An overview of acquired, adult neurologic communication disorders
for purposes of identification and differential diagnosis. Discussion
of the neuronanatomical bases for communication (within a cognitive
framework) will be followed by a review of aphasia, dysarthria,
apraxia, alexia, agraphia, stuttering, palilalia, and mutism, as
well as disorders associated with right hemisphere strokes, closed
head injury, and progressive diseases.
MED BN 795 Neuropsychology of Perception and Memory
The study of normal and abnormal perception and memory as related
to brain structure and function.
MED BN 797 Neuropsychological Assessment II
Overview of structure and function of the central nervous system.
Emphasis on quantitative and qualitative analyses of standardized
and experimental tests of cognitive functions useful in differential
diagnosis of neurological syndromes.
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DEPARTMENT
OF BIOCHEMISTRY (School of Medicine)
GMS MS 783 Molecular Basis of Neurologic Diseases I
Molecular mechanisms of stroke, multiple sclerosis, Huntington's
disease, Alzheimer's disease, amyotropic lateral sclerosis, muscular
dystrophy, and neoplasia reconsidered. Fundamentals and current
research of molecular biology are reviewed. Current publication
seminar discussion is held with student participation. Distinguished
guest speakers give keynote lectures monthly. (2 cr each sem, year
course)
GMS MS 784 Molecular Basis of Neurologic Diseases II
(Year course, see above description)
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DEPARTMENT
OF BIOLOGY (College of Arts and Sciences,
Graduate School of Arts and Sciences)
CAS BI 545 Neurobiology of Motivated Behavior
Neural circuits, neurotransmitter systems, and hormones involved
in the expression of motivated behavior in higher vertebrates. Feeding,
drinking, reproductive and parental behaviors, sleep/wakefulness,
and responses to stress and painful stimuli. Three hours lecture,
one hour discussion.
CAS BI 554 Neuroendocrinology
Interactions between the two major integrative organ systems of
animals and the endocrine and nervous systems in controlling physiological
and behavioral aspects of reproduction, development, energy and
water balance, biochemical homeostasis, biological rhythms, and
body temperature. Three hours lecture, one hour discussion.
CAS BI 575 Techniques in Cellular and Molecular Neuroscience
Laboratory course in which techniques used in cellular neuroscience
are taught. Subjects covered include sensory coding, synaptic transmission,
neural excitability, and cellular neuroanatomy. Eight hours lab.
CAS BI 607 Animal Behavior
Ethological approach to animal behavior. Physiological, ontogenic,
and phylogenic causes and adaptive significance of behavior are
examined within an evolutionary framework, minimally including humans.
Three hours lecture, three hours laboratory.
CAS BI 644 Neuroethology
GRS BI 645 Cellular and Molecular
Neurophysiology
Prerequisite: Cell Biology and Principles of Morphogenesis or consent
of instructor; BI 455 (Neurobiology) helpful. Fundamental principles
in developmental neurobiology, stressing molecular mechanisms; early
neural development, differentiation, process outgrowth; synaptogensis,
brain plasticity, and development of behavior. Three hours lecture,
one hour discussion.
GRS BI 655 Neurobiology
Cellular and molecular biology and physiology of the nervous system.
Lab emphasis on extra- and intra-cellular electrophysiology. Three
hours lecture, three hours lab.
GRS BI 663 Chemosensory Biology
Fundamentals of sensory biology with focus on chemical signals.
Principles of physics, chemistry, and statistics describe signal
noise distributions. Chemical stimuli form the perspective of the
animal and its receptor cells and organs. Also taught at Woods Hole.
GRS BI 676 Neurobiology/Biophysics
GRS BI 681 Molecular Biology of the Neuron
The study of interactions between neurotransmitters and receptors
in the nervous system. Topics include electrical properties of neurons,
a survey of neurotransmitters, molecular structure and function
of receptors, synaptic transmission, intracellular signaling, and
the molecular biology of sensory transduction.
GRS BI 755 Cellular and Systems Neuroscience
Survey course in neurobiology. Topics to be covered include: cell
biology of the neuron, development of the nervous system, synaptic
plasticity, learning and behavior, and network modeling. Three hours
lecture, one hour discussion. 4 cr, 1st sem. Directed Study or Research.
The variable-credit research courses listed below involve reading,
laboratory work, and conferences. Instructor's consent required.
Hours arranged.
GRS BI 756/PS 738, Systems and Cognitive Neuroscience
Team-taught lecture survey course in systems and behavioral neuroscience.
Topics include synaptic plasticity, neurobiology of learning and
memory, behavioral and cognitive neuroscience, cognitive aging,
addiction, and psychiatric disorders, 4 cr, 2nd sem.
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DEPARTMENT
OF BIOMEDICAL ENGINEERING
(College of Engineering)
ENG BE 507 Quantitative Studies
of Excitable Tissues
This course focuses on the properties of the membranes of nerve
and muscle cells. Classical models of resting potentials, action
potentials, synaptic transmission, and sensory receptors are treated.
The structure and function of single ionic channels are characterized
in detail from patch-clamp recordings, neuropharmacological studies,
and molecular studies. Mechanisms of muscle contraction and other
forms of cellular motility are also covered. Includes lab.
ENG BE 515 Introduction to Medical Imaging
Methods of obtaining useful images of the interior of the body using
X-rays, ultrasound, and radionuclides. Image formation and display.
Projection radiography. Radiation detectors. Conventional and computerized
tomography. Nuclear imaging. Automating diagnosis and non-invasive
testing. Radiation safety.
ENG BE 516 Applied Medical Imaging (Summer
Term)
Biomedical engineering course in the format of a clinical rotation
(25 hours per week); this is a six-week course offered only during
the Summer II session. The program consists of separate components
of approximately equal duration and emphasis. An engineering component
with focus in the physics/mathematics/computer subjects most relevant
to medical imaging (attended solely by engineering students) and
a radiological component in lectures and review sessions with medical/clinical
focus (attended together with fourth-year medical students [BUSM-IV]
and first-year radiology residents).
ENG BE 522 Neural and Sensory
Systems
Prerequisites: ENGE BE 402 or permission of instructor. Detailed
study of a single sensorineural system (e.g., auditory, visual,
or tactile). Anatomy and electrophysiology of transducer cells and
neurons at all levels in the brain. Characteristics of external
stimulus and its peripheral transformations. Relation of these topics
to perceptual and/or behavioral responses. Quantitative analysis
and modeling applied throughout. Comparisons with other sensorineural
systems at all levels.
ENG BE 540 Bioelectric Signals: Analysis
and Interpretation
Prerequisite: ENG BE 402 or permission of instructor. Detailed study
of bioelectric signals that can be recorded from awake humans. Alternative
recording and signal processing procedures with attention to relative
advantages and disadvantages, including instrumentation requirements
and examples. Mathematical models that relate signal parameters
to physiological events. Examples given to demonstrate the applicability
of bioelectric signals to control devices external to the body.
Myoelectric signals used as primary examples throughout the course.
ENG BE 550 Bioelectromechanics
Conduction, diffusion, and convection in electrolytes. Equilibrium
double layers and electrical forces in physiological systems. Applications
to physiological systems including membrane/electrolyte and electrode/electrolyte
interfaces, interaction of biomaterials with electric fields, electrophoresis
and electroosmosis, and electromechanical coupling in charged biological
structures.
ENG BE 570 Introduction To Computational Vision
Prerequisites: Graduate or senior standing in engineering, computer
science or physics. Students from CAS—Psychology, Biology,
Health Sciences, or Medical School can enroll in this course with
permission of the instructor. This is an introductory course in
computational visual neuroscience with the primary focus on visual
processing mechanisms and their plasticity in the human brain. The
course will provide (a) a survey of mathematical and neural networks
models for visual mechanisms and of biologically compatible models
for visual information encoding; (b) a survey of the neuroanatomy,
neurophysiology, and psychophysics underlying specific problems
in vision and visuo-motor integration; (c) examples of applications
of computational vision to the neurology of vision and modern techniques
for anatomical localization in the human brain (e.g., MRI, PET,
fMRI).
ENG BE 701 Signal Processing in
the Auditory System: Peripheral Processing
ENG BE 702 Signal Processing in the Auditory
System:
Central Processing
Prerequisite: ENG BE 507 and ENG EK 500
Prerequisite: ENG BE 402 or permission of instructor.
This pair of courses presents an integrated study of auditory physiology
and psychophysics. The first course focuses on the auditory periphery
and includes topcs from physical acoustics to the activity of the
primary auditory neurons. The second course focuses on the neurophysiology
and neuroanatory of the auditory brainstem, although neural activity
up to the cortical level is also included. Psychophysical phenomena
in the first course include hearing thresholds, detection of signals
in noise, intensity perception and loudness, and frequency selectivity.
Psychophysical phenomena in the second course include pitch perception,
sound localization, and binaural detection phenomena.
ENG BE 710 Neural Plasticity and Perceptual
Learning
This course explores the capacity of cortical sensory and motor
maps in the adult brain to change as a result of alterations in
the effectiveness of the input, direct damage, or practice. The
lectures will describe and discuss (1) the physiology and anatomy
underlying adult dynamics; (2) psychophysical methods and experimental
paradigms that have been used to study cortical plasticity in the
early stages of the sensory and motor pathways; (3) evidence for
perceptual learning; and (4) biologically plausible computational
models of learning. We will discuss applications of functional neuroimaging
to study perceptual learning and restorative plasticity in
the human brain.
ENG BE 715 Functional Neuroimaging
This course will explore functional neuroimaging methods, positron
emission tomography (PET) and functional magnetic resonance imaging
(fMRI). Other nonivasive functional techniques, such as transcranial
magnetic stimulation (TMS) and electroencelography (EEG) integrated
with MRI will be discussed and compared with the functional imaging
methods. Emphasis will be on i) the promise and the limitations
of each technique from technological and clinical point of view.
We will discuss the use of these techniques for neurological diagnosis,
function-structure mapping in the human brain, and surgical planing.
ii) Theoretical-engineering basis of these techniques for diagnosis
and evaluation of treatment effects: statistics, principal component
analysis, optic flow algorithms, signal processing and psychophysical
experimental design and data analysis. iii) Most examples will be
drawn from the central visual system, but extension to other central
nervous systems will be briefly discussed.
ENG EK 760 Intelligent Systems: Perceptual
Learning And Plasticity
Extensive discussion of the central issues in constructing machines
capable of intelligent behavior. Computational and biological learning,
neural networks, and fuzzy logic. Class presentations and semester
project required.
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DEPARTMENT
OF COGNITIVE AND NEURAL SYSTEMS
(Graduate School of Arts and Sciences)
CAS CN 500 Computational Methods in Cognitive
and Neural Systems
Introduction to mathematical methods and computer simulation for
modeling cognitive and neural systems. Topics include computer simulation
methods, control theory, difference and differential equations,
digital signal processing, image processing, optimization, and statistics.
Readings from current literature emphasize theory and applications
relevant to the study of cognitive and neural systems.
CAS CN 510 Principles and Methods of
Cognitive and Neural Modeling I
Explores psychological, biological, mathematical, and computational
foundations of behavioral and brain modeling. Topics include organizational
principles, mechanisms, local circuits, network architectures, cooperative
and competitive non-linear feedback systems, associative learning
systems, and self-organizing code-compression systems. The adaptive
resonance theory model unifies many course themes. CAS CN 510 and
520 may be taken concurrently.
CAS CN 520 Principles and Methods of
Cognitive and
Neural Modeling II
Analyzes three main traditions in models of learning: unsupervised
(self-organized) learning, supervised learning (learning with a
teacher), and reinforcement learning. Architectures studied include
adaptive filters, back propagation, competitive learning, self-organizing
feature maps, gradient descent procedures, Boltzmann machines, simulated
annealing, neocognition, and gated dipoles. CAS CN 510 and 520 may
be taken concurrently.
CAS CN 530 Neural and Computational Models
of Vision
Current models of mammalian visual processes are constrained by
experimental and theoretical results from psychology, physiology,
computer science, and mathematics. The course evaluates the explanatory
adequacy of competing neural and computational models of such processes
as edge detection, textural grouping, shape-from-shading, stereopsis,
motion detection, and color perception. Students perform computer
simulations of some of the examined models.
CAS CN 540 Neural and Computational Models
of Adaptive Movement,
Planning, and Control
Neural models of eye, arm, hand, orofacial, and leg movements are
presented and compared to reveal general organizational principles
and specialized neural circuit designs for motor learning and performance.
Issues include trajectory formation, synchronization of synergists,
variable velocity control, adaptive gain control, map formation,
load compensation, serial order, and inflow versus outflow as sources
of sensory-motor information.
CAS CN 550 Neural and Computational Models
of Recognition,
Memory, and Attention
Develops neural network models of how internal representations of
sensory events and cognitive hypotheses are learned and remembered,
and how such internal representations enable recognition and recall
of these events to occur. Various neural pattern recognition models
are analyzed. Special emphasis is placed on stable self-organization
of pattern recognition and recall codes in unpredictable and noisy
environments, notably by adaptive resonance theory models, and on
how such codes direct attention toward predictively relevant combinations
of features, while attenuating irrelevant background cues. Experimental
data and theoretical predictions from cognitive psychology, neuropsychology,
and neurophysiology of normal and abnormal individuals are analyzed.
CAS CN 560 Neural and Computational Models of
Speech Perception
and Production
Develops neural network models of speech perception and production
processes. Emphasis is placed on the role of learning and on the
specialized neural designs that have evolved for purposes of speech
communication. Practical, including industrial, applications of
neural networks for speech processing are also reviewed.
CAS CN 570 Neural and Computational Models
of Conditioning, Reinforcement, Motivation, and Rhythm
Develops neural and computational models of how humans and animals
learn to successfully predict environmental events and generate
behavioral actions that satisfy internally defined criteria of success
or failure. Reinforcement learning and its homeostatic (drive, arousal,
rhythm) and nonhomeostatic (reinforcement) modulators are analyzed
in depth. Recognition learning and recall learning networks are
joined to the reinforcement learning network to analyze how these
several processes cooperate to generate successful goal-oriented
behavior. Maladaptive behaviors and certain mental disorders are
analyzed from a unified theoretical perspective. Applications to
the design of freely moving adaptive robots are noted.
CAS CN 580 Introduction to Computational
Neuroscience
This introductory-level course focuses on building a background
in neuroscience, but with emphasis on computational approaches.
Topics include basic biophysics of ion channels, Hodgkin-Huxley
theory, use of stimulators such as NEURON and GENESIS, recent applications
of the compartmental modeling technique, and a survey of neuronal
architectures of the retina, cerebellum, basal ganglia, and neocortex.
GRS CN 700 Computational and Mathematical
Methods in
Neural Modeling
Introduction to advanced computational topics used in quantitative
modeling. Techniques from signal processing, probability, statistics,
vector quantization, optimal control, and ordinary and partial differential
equations. Theory, simulations, and techniques illustrated with
neural networks and other behavioral and biological models.
GRS CN 710 Advanced Topics in Neural
Modeling
Examines current neural network models to prepare students to participate
in research on an advanced level. Topics are chosen based upon the
latest discoveries and methodologies in the field and upon the research
interests of advanced CNS students.
GRS CN 720 Neural and Computational Models
of Planning and Temporal Structure in Behavior
Identifies characteristics and principles of serial plan formulation,
choice, and learning in humans. Includes theoretical analyses and
neural network modeling of such processes as they appear in communicative
speech and gesture, handwriting, typing, tool use, and object assembly.
GRS CN 730 Models of Visual Perception
Offers advanced survey of topics in the neural and computational
modeling of psychophysical data in mammalian vision. Assignments
include oral presentations on selected readings and a term paper
containing a literature review and model development and analysis.
GRS CN 740 Topics in Sensory-Motor Control
Topics include spatial representation, speech production, and rhythmic
movement. Representations appropriate for handwriting, reaching,
speaking, and walking are investigated with emphasis on different
levels of representation and interactions between these levels.
Material includes psychophysical data, neurophysiology, and neural
models.
GRS CN 760 Topics in Speech Perception and Recognition
This course surveys advanced topics in automatic speech recognition
and auditory representation of speech signals, especially as they
relate to speech perception. The course is constructed around a
thorough introduction to state-of-the-art techniques in automatic
speech recognition and relates these to perspectives obtained from
perceptual and neurophysiological research. The course begins with
the necessary fundamentals in digital signal processing and statistical
pattern recognition, then discusses the major techniques in automatic
speech recognition, including neural networks, hidden markov models,
and dynamic programming. It explores the relation of these techniques
to neurophysiological processing and psycholinguistic data, and
evaluates neural models of auditory processing and speech perception.
Modeling techniques, including parameter optimization and goodness-of-fit
tests, are covered.
GRS CN 780 Topics in Computational Neuroscience
In this seminar, recent research papers and applications in computational
neuroscience are reviewed. Topics covered include cortical modeling,
analog VLSI, active perception, robotic control, stereo vision,
and computer-aided neuroanatomy.
GRS CN 810 Topics in Cognitive and Neural Systems:
TBA
This course offers an advanced treatment of selected topics of current
interest in the neural and computational modeling of mammalian vision.
Examples of topic include visual object recognition, feature integration,
computational maps, nonclassical receptive field characteristics,
brightness perception, shape-form-shading, stereoscopic vision,
motion perception, and optic flow. Topics vary each time the course
is given. Students read primary research sources extensively and
are required to present short oral critiques of selected readings
to the class. A term project that combines literature review with
model simulations or development of a psychophysical experiment
is also required.
GRS CN 811 Topics in Cognitive and Neural
Systems:
Visual Perception
Problems in visual perception. Visual analyzers; visual pathways;
perceptual organization; shape description; object perception; size,
shape, and lightness constancy; motion perception; perceptual adaptation.
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DEPARTMENT
OF MATHEMATICS
(College of Arts and Sciences)
CAS MA 555 Numerical Analysis I
Numerical solutions of equations, iterative methods, analysis of
sequences. Theory of interpolation and functional approximation,
divided differences. Numerical differentiation and integration.
Polynomial theory. Ordinary differential equations.
CAS MA 565 Mathematical Models in the
Life Sciences
An introduction to mathematical modeling, using applications in
the biological sciences. Mathematics includes linear difference
and differential equations, and an introduction to nonlinear phenomena
and qualitative methods. An elementary knowledge of differential
equations and linear algebra is assumed.
CAS MA 573 Qualitative Theory of Ordinary Differential
Equations
Eigenvalues, eigenvectors, Jordan normal forms. Linear systems of
differential equations, Phase portrait, Hamiltonian systems, stability
theory. Applications to systems arising in mechanics, economics,
ecology, electrical circuit theory, etc.
CAS MA 574 Applied Nonlinear Dynamics
Attractors and invariant measures for nonlinear dynamical systems.
Measures of chaos such as Lyapunov exponents. Time series analysis.
Multiple time scales and singular perturbation theory. Synchronization
in coupled oscillators. Strong emphasis on applications to realistic
biological and mechanical systems.
CAS MA 771 Introduction to Dynamical
Systems
Diffeomorphisms and flows; periodic points, nonwandering points,
and recurrent points; hyperbolicity, topological conjugacy, and
structural stability; stable manifold theorem; symbolic dynamics;
Axiom A and chaotic systems.
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DEPARTMENT
OF PHARMACOLOGY (School of Medicine)
MED PM 700 Molecular Neurobiology and Pharmacology
Examines a spectrum of topics ranging from the regulation of gene
expression in the nervous system to the structure and function of
receptors and ion channels. Emphasis is placed on theoretical foundations
of pharmacological methods in neurobiology.
MED PM 840 Neuroendocrine Pharmacology
Covers the basic principles of neuroendocrinology with special emphasis
on pharmacologic aspects. Topics include the biochemistry, physiology,
and pharmacology of the neural hormones, as well as selected topics
in the interrelationship of neurohormones and the immune system.
MED PM 850 Biochemical Aspects of Neurotransmitters
and
Chemical Mediators
Lectures and discussions on biosynthesis, inactivation, receptors,
and signaling mechanisms of neurotransmitters and chemical mediators
including GABA, glutamate, acetylcholine, catecholamines, purines,
peptides, prostaglandins, and histamines.
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DEPARTMENT
OF PSYCHOLOGY (College of Arts and Sciences,
Graduate School of Arts and Sciences)
CAS PS 530 Neural Networks
Computational models of neurobiological mechanisms for memory function
and spatial navigation, with a particular emphasis on cellular and
circuit models of the hippocampus and related cortical structures.
CAS PS 538 Human Brain Mapping
CAS PS 544 Developmental Neuropsychology
Study of the neural mechanisms underlying behavioral development.
Topics include the plasticity of the developing brain in response
to deprivation or damage and mechanisms underlying specific syndromes
(e.g., aphasia, dyslexia, learning disabilities, hyperactivity,
autism, and Tourette's syndrome).
CAS PS 573 Abstract Thought
Discussion of what abstract thought is, who attains it, and how
it is attained. Emphasis on research in cognitive, developmental,
comparative, and neuropsychology. Topics include brain bases, influence
on language, changes with age, animal cognition, and abnormal abstract
thought.
GRS PS 721A Experimental Psychology: Molecular
Genetics in Neurobiology and Behavior
GRS PS 721B Experimental Psychology: Neurobiology of Learning
GRS PS 734 Psychopharmacology
Basic principles of pharmacology, drugs used in treatment of mental
illness, drugs having abuse potential. Current issues in psychopharmacology.
GRS PS 735 Concepts of Motivation
Major theories of human motivation (including biological, psychoanalytic,
and cognitive) are compared and related to empirical research on
important human goals and activities such as achievement, power,
and intimacy. Students identify a research focus and design an empirical
study.
GRS PS 737 Memory Systems of the Brain
Survey of investigations into the brain systems and neurobiological
mechanisms of memory. Includes experimental studies of amnesia associated
with brain damage in humans, experimental models of amnesia in animals,
and neurophysiological studies of brain activity that encodes memories
in animals and humans. Focus on evidence for multiple forms of memory
and distinct brain systems that mediate them.
GRS BI 756/PS 738, Systems and Cognitive
Neuroscience
Team-taught lecture survey course in systems and behavioral neuroscience.
Topics include synaptic plasticity, neurobiology of learning and
memory, behavioral and cognitive neuroscience, cognitive aging,
addiction, and psychiatric disorders.
GRS PS 821 Learning
Basic concepts in behavior theory and analysis of data in operant
and respondent conditioning.
GRS PS 822 Visual Perception
Theory and data relating to contemporary problems in visual perception.
GRS PS 829 Clinical Neurospychology
Central nervous system processes underlying memory, language, cognition,
emotion, sensory functioning and motor function in normal and pathological
conditions. Theory, experimental findings, and reference to clinical
cases.
GRS PS 831 Seminar in Neuropsychology
Central neuron processes underlying emotions, learning and consciousness
in humans and animals. Theory, methods, and experimental findings.
GRS PS 832 Physiological Psychology
Basic brain structure and function as they relate to behavior, methods
of studying these relationships, research findings.
GRS PS 833 Advanced Physiological Psychology
Aspects of learning, memory, and information processing and their
relation to anatomy and physiology of the central nervous system.
GRS PS 846 Psychology of Aging
Changes in cognition, sensation, perception, and other psychological
variables during aging and exploration of factors, from neurological
to environmental, which may explain these changes.
GRS PS 901/902 Directed Study
Research on a special project arranged through a specific professor.
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DEPARTMENT
OF PHYSICS (Graduate School of Arts
and Sciences)
GRS BIOPHYSICS PY 771 Introduction to Biomolecular
Borces,
Energy Flow, and Thermodynamics in Biological Systems
Hydrophobic interactions and membrane structure. Feedback and control
mechanisms; allosteric enzymes. Mechanisms of transport in biological
membranes. Emphasis on the physical principles underlying biological
structure and function.
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HEALTH
SCIENCES (Sargent College of Heath and
Rehabilitation Sciences)
SAR HS 550 Neural Systems
Prerequisite: basic course in neuroscience; knowledge of the principles
of conduction and transmission of neural impulses, and basic concepts
of neural organization. The course explores mechanisms of signal
transduction, communication and integration. The approach is multi-disciplinary,
drawing upon fundamental concepts of the neuroanatomy, neurochemistry
and physiology of the nervous system. The lectures include discussions
on the patterns of processing in sensory, polymodal and motor cortices
in primates. Methods used to investigate the nervous system at different
levels are described and illustrated to facilitate comprehension
of the current literature. It includes tapes of detailed dissection
of the human nervous system. 4 cr. sem 2.
SAR HS 582 Neuroanatomy and Neurophysiology
Prerequisite: HS 581, or permission of instructor. Lecture and lab
related to the detailed study of the development, morphology, internal
configuration, functions, and pathological deficits of the central
nervous system in humans. 4 cr sem 2.
SAR HS 755 Seminar: Readings in
Neuroscience
Prerequisite: consent of instructor. Review of basic neurophysiologic
principles at an intermediate level, followed by seminars on topics
from the current neurosciences research. 4 cr.
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PROGRAM
IN NEUROSCIENCE (Graduate School of Arts
and Sciences)
GRS NE 500/501 Progress in Neuroscience
Seminar series with guest lecturers, professors, and current graduate
students presenting their research. Each student is required to
attend the seminar series throughout his/her graduate career, but
the courses may be taken for credit only once (2 credits each).
GRS NE 800/801/802, Research in Neuroscience
Laboratory/tutorial rotations with participating faculty. All students
must take at least two rotations (6–8 weeks), one of which
must be jointly supervised by an experimental and a computational
neuroscientist.
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