MSE MS Thesis Presentation of Xi Chen
- Starts: 2:00 pm on Friday, August 14, 2020
- Ends: 3:00 pm on Friday, August 14, 2020
ABSTRACT: Nanoparticles have become a robust drug delivery platform and are in extensive use in the pharmaceutical industry. Lipid-wrapped polymer nanoparticles(NP) combine the advantages of liposomes and polymer nanoparticles together and exclude some limitations of both. This thesis reports how to tune the sizes of lipid-wrapped polymer nanoparticles by changing the lipid/polymer ratio, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine(DOPS) composition in lipids and the choice of polymer material. Also the stability of the synthesized nanoparticles were tested in terms of size at different time points up to 7 days. The lipid-wrapped polymer NPs were prepared by one-step nanoprecipitation and self assembly taking the energy of bath sonication within five minutes. We characterized NPs by measuring the hydrodynamic diameters and zeta potential through Dynamic Light Scattering(DLS). The result of this project has the potential use in precisely controlling the sizes of drug-loaded nanoparticles and scaling up the production in pharmaceutical manufacture. Keywords: Liposome; polymer nanoparticle; nanoprecipitation; stability.
COMMITTEE: Advisor: Bjoern Reinhard, MSE, Chemistry; Rahm Gummuluru, MED Microbiology