MSE Colloquium: Srikanth Singamaneni, Washington University

1:30 pm on Friday, October 18, 2013
2:30 pm on Friday, October 18, 2013
15 St. Mary’s Street, Room 105
Abstract: Plasmonics involves the control of light at the nanoscale using surface plasmons. One particular area where plasmonics is expected to make an enoromous impact is the field of life sciences, with applications in bioimaging, biosensing, and therapy. In the first part of this talk, we present a novel class of ultrabright surface enhanced Raman scattering (SERS) probes based on core-satellite and core-shell plasmonic nanostructures. We call the core-shell nanostructures as bi-layered Raman-intense gold nanostructures with hidden tags (BRIGHTs), which are nearly 20 times brighter compared to the exisiting SERS probes. Such BRIGHT probes can be incorporated into drug carrying vehicles (gold nanocages) to form multifunctional nanorattles that facilitate the monitoring of drug release non-invasively. In the second part of this talk, we demonstrate that a filter paper loaded with biofunctionalized metal nanoparticles enables the detection of target disease biomarkers in complex physiological fluids. Natural antibodies, which suffer from numerous shortcomings such as limited environmental and chemical stability, have been replaced with artificial antibodies by molecularly imprinting the plasmonic nanotransducers. Apart from significantly lowering the cost, these developments are critical for translating plasmonic sensors to point-of-care and resource-limited settings.