Yanjun Gong’s research project focuses on monodisperse ultrasound contrast agents (UCA), including its acoustic properties (scattering cross section, resonance frequency, nonlinear oscillation, etc.) and applications in imaging. At present, most UCA microbubbles have a wide size distribution (1-10 µm in diameter), which limits their applications in medical diagnosis and therapy.
By using microfluidic technique, size-controllable populations of UCA microbubbles have been produced. Based on this, currently I am working on the dependence of resonance frequency on microbubbles’ size and incident sound pressure, respectively. Furthermore, the microbubble shell elasticity parameter can be estimated. My future work will be also aimed at the ultrasound scattering from single microbubbles, both in free area and elastic microchannels. This work can be applied in molecular imaging.