Catherine Klapperich Ph.D.


Associate Professor

Department of Biomedical Engineering
Department of Mechanical Engineering

Director, Center for Future Technologies in Cancer Care
Primary appointment, BME

Ph.D., University of California, Berkeley

phone: (617) 358-0253
office: 44 Cummington Mall, ERB 725, Boston, MA 02215

Research Interests

The Klapperich Laboratory for Diagnostics and Global Healthcare Technologies is focused on the design and engineering of manufacturable, disposable systems for low-cost point-of-care molecular diagnostics. We have invented technologies to perform microfluidic sample preparation for bacterial and viral targets from several human body fluids including, urine, blood, stool and nasowash.  These technologies include nucleic acid extraction, protein extraction, microorganism enrichment and/or concentration and small-scale dialysis. We are currently working on devices for the detection and quantification of HIV, hemorrhagic fevers, infectious diarrheas, influenza, MRSA and cancer biomarkers.

Selected Publications
M. Mahalanabis, H. Al-Muayad, M. D. Kulinski, D. Altman and C. M. Klapperich, “Cell lysis and DNA extraction of Gram-positive and Gram-negative Bacteria from Whole Blood in a Disposable Microfluidic Chip”, Lab on a Chip, DOI: 10.1039/B905065P, 2009.
2.     Alexis Sauer-Budge, Paul Mirer, Anirban Chatterjee, Catherine Klapperich, David Chargin, Andre Sharon, “Low cost and manufacturable complete microTAS for detecting bacteria,” Lab on a Chip, DOI: 10.1039/B904854E, 2009.
3.     Sara Gillers, Christopher D. Atkinson, Aaron C. Bartoo, Madhumita Mahalanabis, Michael O. Boylan, John H. Schwartz, Catherine Klapperich, and Satish K. Singh, “Microscale sample preparation for PCR of C. difficile infected stool,” Journal of Microbiological Methods, DOI:10.1016/j.mimet.2009.05.020, 2009.
4.     Kulinski, M.D., Mahalanabis, M., Gillers, S., Zhang, J.Y., Singh, S., and Klapperich, C.M., “Sample Preparation Module for Bacterial Lysis and Isolation of DNA from Human Urine,” Biomedical Microdevices, DOI:10.1007/s10544-008-9277-1, 2009.
5.     Bhattacharyya, A. and C.M. Klapperich,”Microfluidics -Based Extraction of Viral RNA for Disposable Molecular Diagnostics, ” Sensors and Actuators B: Chemical, 129, p. 693–698, 2008.
6.     Bhattacharyya and C. M. Klapperich, “Mechanical and chemical analysis of plasma and ultraviolet–ozone surface treatments for thermal bonding of polymeric microfluidic devices,” Lab Chip, 7 (7), 2007.
7.     Bhattacharyya, A. and C.M. Klapperich, “Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples,” Biomedical Microdevices, 9, 245-251 (2007).
8.     Bhattacharyya, A. and C.M. Klapperich, “Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics,” Analytical Chemistry, 78(3): p. 788-92, 2Samantha Byrnes, Andy Fan, Jacob Trueb, Francis Jareczek, Mark Mazzochette, Andre Sharon, Alexis F. Sauer-Budge and Catherine M. Klapperich, (2013) A portable, pressure driven, room temperature nucleic acid extraction and storage system for point of care molecular diagnostics, Anal. Methods, Advance Article DOI: 10.1039/C3AY40162F, Anal Methods 2013