Catherine Klapperich Ph.D.

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Assistant Professor, Biomedical Engineering
Assistant Professor, Mechanical Engineering
Primary appointment, BME

Ph.D., University of California, Berkeley

phone: (617) 358-0253
email: catherin@bu.edu
website: www.bu.edu/klapperich/
office: 44 Cummington Street, ERB 725

Research Interests

The Biomedical Microdevices and Microenvironments Laboratory (BMML) is focused on the design and engineering of manufacturable, disposable microfluidic systems for low-cost point-of-care molecular diagnostics. We are currently working on devices for the detection of infectious diarrhea, influenza and MRSA.

Selected Publications
M. Mahalanabis, H. Al-Muayad, M. D. Kulinski, D. Altman and C. M. Klapperich, “Cell lysis and DNA extraction of Gram-positive and Gram-negative Bacteria from Whole Blood in a Disposable Microfluidic Chip”, Lab on a Chip, DOI: 10.1039/B905065P, 2009.
2.     Alexis Sauer-Budge, Paul Mirer, Anirban Chatterjee, Catherine Klapperich, David Chargin, Andre Sharon, “Low cost and manufacturable complete microTAS for detecting bacteria,” Lab on a Chip, DOI: 10.1039/B904854E, 2009.
3.     Sara Gillers, Christopher D. Atkinson, Aaron C. Bartoo, Madhumita Mahalanabis, Michael O. Boylan, John H. Schwartz, Catherine Klapperich, and Satish K. Singh, “Microscale sample preparation for PCR of C. difficile infected stool,” Journal of Microbiological Methods, DOI:10.1016/j.mimet.2009.05.020, 2009.
4.     Kulinski, M.D., Mahalanabis, M., Gillers, S., Zhang, J.Y., Singh, S., and Klapperich, C.M., “Sample Preparation Module for Bacterial Lysis and Isolation of DNA from Human Urine,” Biomedical Microdevices, DOI:10.1007/s10544-008-9277-1, 2009.
5.     Bhattacharyya, A. and C.M. Klapperich,”Microfluidics -Based Extraction of Viral RNA for Disposable Molecular Diagnostics, ” Sensors and Actuators B: Chemical, 129, p. 693–698, 2008.
6.     Bhattacharyya and C. M. Klapperich, “Mechanical and chemical analysis of plasma and ultraviolet–ozone surface treatments for thermal bonding of polymeric microfluidic devices,” Lab Chip, 7 (7), 2007.
7.     Bhattacharyya, A. and C.M. Klapperich, “Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples,” Biomedical Microdevices, 9, 245-251 (2007).
8.     Bhattacharyya, A. and C.M. Klapperich, “Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics,” Analytical Chemistry, 78(3): p. 788-92, 2006.
  • Madhumita Mahalanabis, Jaephil Do, Hussam ALMuayad, Jane Y. Zhang and Catherine M. Klapperich, “An integrated disposable device for DNA extraction and helicase dependent amplification,” Biomedical Microdevices, DOI: 10.1007/s10544-009-9391-8, Jan 12, 2010.
  • M. Mahalanabis, H. Al-Muayad, M. D. Kulinski, D. Altman and C. M. Klapperich, “Cell lysis and DNA extraction of Gram-positive and Gram-negative Bacteria from Whole Blood in a Disposable Microfluidic Chip,” Lab on a Chip, DOI: 10.1039/B905065P, 2009.
  • Alexis Sauer-Budge, Paul Mirer, Anirban Chatterjee, Catherine Klapperich, David Chargin, Andre Sharon, “Low cost and manufacturable complete microTAS for detecting bacteria,” Lab on a Chip, DOI: 10.1039/B904854E, 2009.
  • Sara Gillers, Christopher D. Atkinson, Aaron C. Bartoo, Madhumita Mahalanabis, Michael O. Boylan, John H. Schwartz, Catherine Klapperich, and Satish K. Singh, “Microscale sample preparation for PCR of C. difficile infected stool,” Journal of Microbiological Methods, DOI:10.1016/j.mimet.2009.05.020, 2009.
  • Kulinski, M.D., Mahalanabis, M., Gillers, S., Zhang, J.Y., Singh, S., and Klapperich, C.M., “Sample Preparation Module for Bacterial Lysis and Isolation of DNA from Human Urine,” Biomedical Microdevices, DOI:10.1007/s10544-008-9277-1, 2009.
  • Bhattacharyya, A. and C.M. Klapperich,”Microfluidics -Based Extraction of Viral RNA for Disposable Molecular Diagnostics, ” Sensors and Actuators B: Chemical, 129, p. 693–698, 2008.
  • Bhattacharyya and C. M. Klapperich, “Mechanical and chemical analysis of plasma and ultraviolet–ozone surface treatments for thermal bonding of polymeric microfluidic devices,” Lab on a Chip, 7 (7), 2007.
  • Bhattacharyya, A. and C.M. Klapperich, “Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples,” Biomedical Microdevices, 9, 245-251, 2007.
  • Bhattacharyya, A. and C.M. Klapperich, “Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics,” Analytical Chemistry, 78(3): p. 788-92, 2006.