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Ralph D’Agostino

Ralph D'Agostino


Longitudinal data analysis, multivariate data, analysis, biostatistics and robust procedures

Office MCS 154
Phone 617-353-0919
Website Ralph D’Agostino
Office Hours by appointment
CV Ralph D’Agostino


PhD, Harvard University, 1968


RALPH B. D’AGOSTINO, Sr., is Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968).

His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980s)developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is affiliated Harvard Clinical Research Institute (HCRI), a non-profit research institute specializing in device and drug clinical trials.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

He has over six hundred publications in peer reviewed journals and is co-author/editor of eleven books: Factor Analysis: An Applied Approach, Goodness-of-Fit Techniques, Mathematical Models in Health Services Research, Practical Engineering Statistics, Tutorials in Biostatistics, Introductory Applied Biostatistics, Pharmaceutical Statistics Using SAS: A Practical Guide, Managing Cardiovascular Risk and Therapeutic Strategies in Cardiovascular Risk, Places Rated Almanac and The Prevention and Treatment of Missing Data in Clinical Trials.

He has served on the editorial boards of the American Statistician, Journal of the American Statistical Association, Biostatistica, and Health Services and Outcomes Research Methodology. Presently, he is an Editor of Statistics in Medicine, Statistical Consultant to the New England Journal of Medicine, and on the editorial board of Current Therapeutic Research and Trials. He is also an Editor of the Encyclopedia of Clinical Trial.