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Robert Jackman - Research Associate Professor

Contact Information:

rjackman@bu.edu


Research Summary:

2002-present, working on conditional expression systems

Professional Positions:

1982-1987 Postdoctoral Fellow, Massachusetts Institute of Technology, Cambridge MA
1987-1989 Postdoctoral Associate, Massachusetts Institute of Technology, Cambridge MA
1989-1990 Instructor in Pathology, Harvard Medical School, Boston MA
1990-1995 Assistant Professor of Pathology, Harvard Medical School, Boston MA
1995-2001 Principal Associate in Pathology, Harvard Medical School, Boston MA
2001-2002 Cellicon Biotechnologies, Boston, Massachusetts, Director of Science
2002- Research Associate Professor, Department of Health Sciences, Boston University, Boston MA


Honors & Advisory Board Activity:

1979-81 USPHS pre-doctoral Fellowship
1982-84 Johnson and Johnson Postdoctoral Fellowship
1989 Salary award from the Ministere des Affaires Etrangeres de France
1993-2000 Extramural Grant support from Baxter Health Care Renal Division


Education:

PhD., Cell and Developmental Biology, University of Minnesota, Minneapolis
B.S., Zoology, University of Washington, Seattle

 

Peer reviewed publications:

Jackman RW. Persistence of Axial Orientation Cues in Regenerating Intima of Cultured Aortic Explants. Nature 1982; 296:80-3. [Abstract]


Jackman RW, Beeler DL, Van De Water L, Rosenberg RD. Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor. Proc Natl Acad Sci USA 1986; 83:8834-8. [Abstract]


Hobbie L, Kingsley DM, Kozarsky KF, Jackman RW, Krieger M. Restoration of LDL receptor activity in mutant cells by intercellular communication. Science 1987; 235:69-73. [Abstract]


Jackman RW, Beeler DL, Fritze L, Soff G, Rosenberg RD. Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. Proc Natl Acad Sci USA 1987; 84:6425-9. [Abstract]


Jackman RW, Anderson SK, Sheridan JD. The aortic intima in organ culture; response to culture conditions and partial endothelial denudation. Am J Pathol 1988; 133:241-51. [Abstract]


Soff GA, Jackman RW, Rosenberg RD. Expression of thrombomodulin by smooth muscle cells in culture: different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture. Blood 1991; 77: 515-8. [Abstract]


Boffa MC, Jackman RW, Peyri N, Boffa JF, George B. Thrombomodulin in the Central Nervous System. Nouv. Rev. Fr. Hematol. 1991; 33: 423-9. [Abstract]


Yu K, Morioka H, Fritze LMS, Beeler DL, Jackman RW and Rosenberg RD. Transcriptional Regulation of the Thrombomodulin Gene. J. Biol. Chem. 1992; 267: 23237-23247. [Abstract]


Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Dvorak HF and Senger DR; Increased Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) and its Receptors in Kidney and BladderCarcinomas; American Journal of Pathology 1993, 143: 1255-1262. [Abstract]


Senger DR, Van De Water L, Brown LF, Nagy JA, Yeo K-T, Yeo T-K, Berse B, Jackman RW, Dvorak AM, Dvorak HF. Vascular Permeability Factor (VPF, VEGF) in Tumor Biology. Cancer Met Reviews 1993; 12: 303-324. [Abstract]


Detmar, M., L.F. Brown, K.P. Claffey, K-T Yeo, O. Kocher, R.W. Jackman, B. Berse and H.F. Dvorak; Overexpression of Vascular Permeability Factor/Vascular Endothelial Growth Factor and its Receptors in Psoriasis; J. Exp. Med. 1994; 180:1141-1146. [Abstract]


Conway, E.M., L. Liu, B. Nowakowski, M. Steiner-Mosonyi and R.W. Jackman; Heat Shock of Vascular Endothelial Cells Induces an Up-regulatory Transcriptional Response of the Thrombomodulin Gene That Is Delayed in Onset and Does Not Attenuate. J. Biol. Chem. 1994; 269: 22804-22810. [Abstract]


Brown LF, Berse B, Jackman RW, Tognazzi K, Guidi A, Dvorak HF, Senger DS, Connolly JL, Schnitt SJ. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol. 1995; 26:86-91. [Abstract]


Kent KC, Wroblewski L, Jackman RW, Skillman JJ. Platelet attachment stimulates endothelial cell regeneration after arterial injury. Surgery 1995; 117:276-81. [Abstract]


Nagy JA, Shockley TR, Masse EM, Harvey, VS, Jackman RW. Mesothelial cell-mediated gene therapy: Feasibility of An Ex Vivo Strategy. Gene Therapy 1995; 2:393-401. [Abstract]


Nagy JA, Shockley TR, Masse EM, Harvey, VS, Hoff CM, Jackman RW. Systemic Delivery of a Recombinant Protein by Genetically-Modified Mesothelial Cells Reseeded on the Parietal Peritoneal Surface. Gene Therapy 1995; 2:402-10. [Abstract]


Detmar M, Brown LF, Berse B, Jackman RW, Elicker BM, Dvorak HF, Claffey, KC. Hypoxia regulates the expression of vacular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatol 1997; 108:263-268. [Abstract]


Nagy JA and Jackman RW. Anatomy and Physiology of the Peritoneal Membrane. Sem. Dial. 11:49-56, 1998.


Nagy JA and Jackman RW. Response of the Peritoneal Membrane to Injury. Sem. Dial. 11:242-248, 1998.


Hoff CM, Cusick JL, Masse EM, Jackman RW, Nagy JA and Shockley TR. Modulation of Transgene Expression in Mesothelial Cells by Activation of an Inducible Promoter. Nephrol. Dial. Transplant., 13:1420-1429, 1998. [Abstract]


Jackman RW, Stapleton TD, Masse EM, Harvey VS, Meyers MS, Shockley TR and Nagy JA. Enhancement of the Functional Repertoire of the Parietal Peritoneal Mesothelium In Vivo: Directed Expression of the Anticoagulant and Anti-inflammatory Molecule Thrombomodulin. Human Gene Therapy. 9:1069-1081, 1998. [Abstract]


Jackman, RW, Hoff, CM, Shockley, TR, JA Nagy. Adenovirus-mediated transfer of rat catalase cDNA into rat primary mesothelial cells confers increased resistance to oxidant-induced injury in vitro. J. Am. Soc. Nephrol. 1999;10:446A.


Hekking, LHP, VS Harvey, CEG Havenith, J van den Born, RHJ Beelen, RW Jackman, JA Nagy. Genetically-modified mesothelial cells as a tool to visualize mesothelial cell damage in models of acute inflammation and chronic peritoneal dialysis. Peritoneal Dialysis International 2003 (in press).


Koncarevic, A., Jackman, R., Kandarian, S. Upregulation of ubiquitin-protein ligase Nedd4 in muscle disuse atrophy. Molecular Biology of Muscle Development and Regeneration. The Banff Centre, Alberta, Canada, June 2, 2003.