Probe_ID gene_name day1 day4 day7 day14 function possible_pathways notes M59861_at 10-formyltetrahydrofolate dehydrogenase 1.1 3.3 2.8 2.2 metabolism; miscellaneous rc_AA817846_at 3-hydroxybutyrate dehydrogenase -1.1 -2.2 -1.8 -3.1 protein turnover; metabolism rc_AA892799_s_at "3-phosphoglycerate dehydrogenase, ESTs, (rat)" 2.6 2.1 2.2 1.6 protein turnover; metabolism; protein; amino acid U70825_at 5-oxoprolinase (ATP-hydrolysing) 1.2 1.6 1.6 2.0 protein turnover; metabolism; protein; amino acid S50879_g_at Acetylcholinesterase T subunit 1.7 1.6 1.6 2.3 contraction; unclassified; membrane depolarization S50879_at Acetylcholinesterase T subunit 1.2 1.1 2.2 1.5 contraction; unclassified; membrane depolarization X80130cds_f_at "Actin, alpha- (cardiac)" -1.5 -2.2 -1.3 -1.0 contraction; embryonic; cytoskeleton/sarcomere rc_AA866452_s_at "Actin, alpha- (cardiac)" -2.0 -3.1 -1.2 1.4 contraction; embryonic; cytoskeleton/sarcomere X80130cds_i_at "Actin, alpha- (cardiac)" -1.8 -2.8 -1.1 1.5 contraction; embryonic; cytoskeleton/sarcomere rc_AA800206_at "Actinin 1, alpha EST (rat)" -1.0 -2.1 -2.2 -1.7 contraction; unclassified; cytoskeleton/sarcomere L10640_s_at Activin type IIB receptor 3.1 2.5 5.1 5.8 regulatory; growth/proliferation; growth factor activity; TGF-beta transmembrane receptor; secreted growth factor activity; SMAD; TGFbeta receptor signaling pathway M98819mRNA_s_at Adenosine monophosphate deaminase 1 1.1 1.6 2.0 1.9 protein turnover; metabolism; protein; amino acid rc_AI176052_at Adenylate kinase 3 1.2 2.2 1.9 1.9 metabolism; carbohydrate; glycolytic X59864mRNA_at Adult skeletal muscle gene 15; H19 -1.0 -2.1 -2.1 -1.4 regulatory; growth/proliferation; proliferation IGF; development; translation regulator; 4E-BP1; p70(S6k) The results showed that the well-documented early effects of clenbuterol on protein metabolism were preceded by elevated levels of IGF-II and H19 transcripts together with increased phosphorylation of eukaryotic initiation factor (eIF)4E binding protein-1 X59864mRNA_g_at Adult skeletal muscle gene 15; H19 -1.0 -2.3 -2.3 -1.5 regulatory; growth/proliferation; proliferation IGF; development; translation regulator; 4E-BP1; p70(S6k) The results showed that the well-documented early effects of clenbuterol on protein metabolism were preceded by elevated levels of IGF-II and H19 transcripts together with increased phosphorylation of eukaryotic initiation factor (eIF)4E binding protein-1 AF001898_at Aldehyde dehydrogenase 1 1.3 1.4 2.2 1.5 metabolism; aldehyde rc_AI172017_at aldehyde dehydrogenase 2 1.4 2.0 1.9 1.3 metabolism; aldehyde M12919mRNA#2_at "Aldolase A, fructose-bisphosphate" -1.0 1.2 1.9 2.4 metabolism; carbohydrate; glycolytic rc_AA924326_s_at "Aldolase A, fructose-bisphosphate" 1.0 1.4 2.3 2.8 metabolism; carbohydrate; glycolytic X60351cds_s_at Alpha B-crystallin -1.4 -6.6 -5.9 -4.2 protein turnover; protein folding AF051895_at Annexin 5 -1.2 -2.2 -2.1 -2.2 regulatory; growth/proliferation; proliferation apoptosis; calcium signaling D42137exon_s_at Annexin 5 -1.0 -2.5 -2.4 -2.1 regulatory; growth/proliferation; proliferation apoptosis; calcium signaling J03627_at "Annexin II ligand, calpactin I (S100a10)" -1.2 -1.8 -2.0 -2.4 regulatory; signal transduction calcium signaling; cell cycle; differentiation U49062_at Antigen CD24 3.7 5.7 11.0 13.0 stress; immune; antigen U49062_g_at Antigen CD24 2.5 2.8 2.7 1.8 stress; immune; antigen rc_AA818025_g_at Antigen CD59 1.6 2.0 2.2 2.7 stress; immune; antigen rc_AA818025_at Antigen CD59 1.4 1.8 1.8 2.2 stress; immune; antigen S76779_s_at apolipoprotein E 1.6 1.9 2.1 1.9 metabolism; lipid; uptake and transport U47315_s_at Apoptosis-regulating basic protein 1.2 -2.1 -1.9 -2.0 regulatory; growth/proliferation; proliferation; apoptosis apoptosis; D44495_s_at apurinic/apyrimidinic endonuclease 1 2.1 1.9 1.4 1.3 regulatory; transcription cAMP responsive; DNA repair; stress or injury U14007_at Aquaporin 4 -1.1 1.4 3.4 3.3 ion transport; sodium/phosphate symporter water transport AB000507_at Aquaporin 7 -1.3 -2.8 -1.9 -3.0 ion transport; sodium/phosphate symporter water transport J05210_g_at ATP citrate lyase 1.2 1.3 1.2 2.1 metabolism; tricarboxylic acid cycle D13123_s_at "ATP synthase, H+ transporting, mitochondrial F0 complex, subunit 9" -1.1 -1.7 -2.2 -1.8 metabolism; respiratory chain rc_AI177026_at ATPase Na K transporting alpha 2 1.6 2.5 2.7 1.9 ion transport; sodium/potassium rc_AI112173_at ATPase Na K transporting beta 1 -1.2 -2.2 -1.6 -1.2 ion transport; sodium/potassium rc_AI230614_s_at ATPase Na K transporting beta 1 -1.0 -2.1 -1.4 -1.4 ion transport; sodium/potassium M99223_at "ATPase, Ca++ transporting, cardiac muscle, fast twitch 1" 1.2 2.9 3.8 5.9 contraction; fast; membrane depolarization X96394_at "ATP-binding cassette, sub-family C ( CFTR/MRP), member 1a" 5.4 2.6 3.3 3.1 stress; oxidative/toxic S48813_s_at Beta-adrenergic receptor kinase -1.1 1.6 3.7 6.8 regulatory; signal transduction stress or injury; GTP signaling AF056034_s_at b-Nexilin 1.0 -2.0 -2.1 -1.2 regulatory; adhesion adhesion rc_AA799423_at b-Nexilin -1.0 -1.9 -2.1 -1.4 regulatory; adhesion adhesion J02827_at Branched chain alpha-ketoacid dehydrogenase subunit E1 alpha 1.6 2.1 2.1 1.8 protein turnover; metabolism; protein; amino acid U35774_at "Branched chain aminotransferase 1, cytosolic" -1.5 -2.3 -1.4 -1.0 protein turnover; metabolism; protein; amino acid rc_AA891614_at "Calcium channel, voltage gated (Tpcn1)" 1.2 1.7 1.1 2.4 contraction; membrane depolarization Y09453cds_at "Calcium channel, voltage-dependent, gamma subunit 1" 1.2 1.9 1.9 2.3 contraction; fast; membrane depolarization M16112_at Calcium/calmodulin-dependent protein kinase II beta 1.8 -1.5 -1.5 -2.8 regulatory; signal transduction calcium signaling S71570_s_at Calmodulin-dependent protein kinase 2 gamma 2.0 2.1 2.0 1.7 regulatory; signal transduction calcium signaling X56729mRNA_at Calpastatin/CANP inhibitor 2.8 4.0 1.3 4.5 protein turnover; proteolysis; protease inhibitor; calpain U33287_at Calsequestrin 2 1.1 -2.7 -4.1 -3.0 contraction; slow; cytoskeleton/sarcomere U04835_at cAMP responsive element modulator (CREM) -11.2 -2.5 -2.0 -1.4 regulatory; transcription cAMP responsive; translation regulator S66024_at cAMP responsive element modulator (CREM) -8.6 -6.6 -1.5 -2.7 regulatory; transcription cAMP responsive; translation regulator AF037072_at Carbonic anhydrase 3 -1.1 -4.9 -8.8 -7.7 metabolism; miscellaneous X65296cds_s_at carboxylesterase 1.7 9.6 4.0 3.2 metabolism; lipid L46791_at carboxylesterase 3 7.6 10.6 1.0 2.6 metabolism; lipid U50736_s_at Cardiac ankyrin repeat protein (Carp) -2.5 -1.7 -2.5 -6.7 regulatory; transcription cytokine signaling; differentiation; development D90404_at Cathepsin C 1.8 2.1 2.4 3.0 protein turnover; proteolysis; protease; lysosomal D90404_g_at Cathepsin C (dipeptidyl peptidase I) -1.3 1.1 5.6 4.0 protein turnover; proteolysis; protease; lysosomal X54467_at Cathepsin D (preprocathepsin) 1.2 2.3 1.9 1.5 protein turnover; proteolysis; protease; lysosomal S85184_at Cathepsin L 1.1 3.3 5.1 1.6 protein turnover; proteolysis; protease; lysosomal rc_AI176595_s_at Cathepsin L 1.4 3.1 4.6 2.2 protein turnover; proteolysis; protease; lysosomal S85184_g_at Cathepsin L proenzyme 1.2 1.7 2.6 1.4 protein turnover; proteolysis; protease; lysosomal rc_AI014091_at Cbp/p300-interacting transactivator 2; Mrg1 2.8 2.0 2.6 1.3 regulatory; transcription development; apoptosis; myogenesis rc_AA900476_g_at Cbp/p300-interacting transactivator 2; Mrg1 1.7 1.5 2.2 1.5 regulatory; transcription development; apoptosis; myogenesis rc_AA900476_at Cbp/p300-interacting transactivator 2; Mrg1 5.2 2.2 6.6 3.4 regulatory; transcription development; apoptosis; myogenesis AB000199_at CCA2 protein -1.8 -2.1 -2.7 -2.6 unknown D26439_at CD1D antigen 2.0 1.7 1.3 1.3 stress; immune; antigen X13044_g_at CD74 antigen (invariant polpypeptide of major histocompatibility class II antigen-associated) -1.1 1.3 2.1 1.6 stress; oxidative/toxic X13044_at CD74 antigen (invariant polpypeptide of major histocompatibility class II antigen-associated) 1.0 1.3 2.3 1.3 stress; immune; antigen X94351_at CDC-like kinase 3 2.3 1.9 1.6 1.5 regulatory; signal transduction SR protein localization; mRNA splicing "The prototype, murine Clk1 (mClk1), is a nuclear dual-specificity kinase that can interact with, and cause the nuclear redistribution of, SR proteins." rc_AA860015_at cDNA clone 617608 -1.2 -2.1 -1.1 -1.1 unknown rc_AA858588_g_at cDNA clone 864365 1.6 2.0 2.5 1.6 unknown rc_AA817854_s_at Ceruloplasmin (ferroxidase) 1.1 1.4 3.7 2.7 stress; oxidative/toxic L33869_at Ceruloplasmin (ferroxidase) -1.4 1.3 2.0 2.5 stress; oxidative/toxic X62894_at Chloride channel 1 (skeletal muscle) 2.5 1.3 3.1 4.2 contraction; unclassified; membrane depolarization AF072892_s_at Chondroitin sulfate proteoglycan 2 -2.1 -1.8 -1.7 -1.3 regulatory; growth/proliferation; ECM rc_AI175959_at "c-Jun, EST (human)" 1.3 1.7 3.1 2.2 regulatory; transcription apoptosis; SMAD; AP1; NFkB; ferritin X53054_at Class II MHC RT1.D(n) beta chain precursor 1.0 1.2 10.8 4.2 stress; immune; antigen X53054_g_at Class II MHC RT1.D(n) beta chain precursor -1.1 1.1 2.4 1.3 stress; immune; antigen AB000362_at Cold inducible RNA-binding protein 2.7 3.4 2.9 2.7 regulatory; mRNA processing RNA stability; shock rc_AI231472_s_at "Collagen, alpha 1 type I" 1.1 -1.4 -1.5 -2.2 ECM structrual/regulator U75405UTR#1_f_at "Collagen, alpha 1 type I" -1.0 -1.1 -1.6 -2.0 ECM structrual/regulator rc_AI179399_at "Collagen, alpha 2 type V" -1.1 -1.2 -1.5 -2.0 ECM structrual/regulator U42719_at Complement component 4 1.9 2.6 1.3 3.4 protein turnover; proteolysis; protease M31725_at Contactin 2 2.2 1.8 1.8 -1.0 regulatory; adhesion development; adhesion; membrane targeting M55534mRNA_s_at "Crystallin, alpha polypeptide 2" -1.2 -6.5 -6.2 -4.7 protein turnover; protein folding U21101_at cyclic GMP stimulated phosphodiesterase 1.3 2.9 2.4 3.1 regulatory; signal transduction cAMP regulator; U24174_at Cyclin-dependent kinase inhibitor 1A (P21) 1.9 2.0 14.2 2.5 regulatory; growth/proliferation; proliferation; cell cycle arrest cytokine signaling; G1 cyclin/CDK complex inhibtion; p53; AKT/PKB induced; apoptosis; differentiation; development; cell cycle arrest; tumor suppressor; oncogenesis L41275cds_s_at Cyclin-dependent kinase inhibitor 1A (P21) 1.3 2.1 19.4 4.9 regulatory; growth/proliferation; proliferation; cell cycle arrest cytokine signaling; G1 cyclin/CDK complex inhibtion; p53; AKT/PKB induced; apoptosis; differentiation; development; cell cycle arrest; tumor suppressor; oncogenesis rc_AI231292_g_at Cystatin C 1.5 1.9 2.5 2.2 protein turnover; proteolysis; protease inhibitor; cathepsin rc_AI231292_at Cystatin C 1.4 2.1 3.2 3.1 protein turnover; proteolysis; protease inhibitor; cathepsin S61960_s_at Cysteine conjugate beta-lyase 2.2 2.4 1.6 1.2 protein turnover; metabolism; protein; amino acid rc_AA942685_at Cysteine dioxygenase 1 1.4 3.2 3.1 1.8 protein turnover; metabolism; protein; amino acid Y12517cds_at "Cytochrome b5, outer mitochondrial membrane isoform" 3.1 1.1 1.2 1.4 metabolism; respiratory X64827cds_s_at Cytochrome C oxidase subunit VIIIh (heart/muscle) 1.2 -1.4 -1.6 -2.6 metabolism; respiratory AF055884_s_at DEAF-1 related transcriptional regulator (NUDR) -1.5 1.3 1.8 2.2 regulatory; transcription rc_AI010581_at Diazepam binding inhibitor -1.0 -2.0 -3.0 -2.0 protein turnover; proteolysis; protease inhibitor rc_AA799732_at DiGeorge syndrome critical region gene 6; EST (mouse) 1.4 2.3 1.4 1.4 regulatory; growth/proliferation; ECM rc_AA891107_at Diphosphoinositol polyphosphate phosphohydolase t2 -1.3 -2.0 -1.6 -2.3 regulatory; signaling intracellular trafficking "The turnover of the ""high energy"" diphosphoinositol polyphosphates by Ca(2+)- and cyclic nucleotide-modulated enzymes is considered a regulatory, molecular switching activity. Target processes may include intracellular trafficking." U14950_at "Discs, large homolog 1 (Drosophila)" 1.9 2.2 2.5 1.6 regulatory; cytoskeletal regulator PDZ; SH3; cytoskeletal organization; tumor supressor L32591mRNA_g_at DNA-damage-inducible transcript 1 2.1 2.9 1.8 1.7 regulatory; growth/proliferation; proliferation; cell cycle arrest DNA repair; stress or injury; cell cycle arrest; p38/JNK; translation regulator; G2-M arrest; apoptosis The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. L32591mRNA_at DNA-damage-inducible transcript 1 1.4 4.1 1.9 2.3 regulatory; growth/proliferation; proliferation; cell cycle arrest DNA repair; stress or injury; cell cycle arrest; p38/JNK; translation regulator; G2-M arrest; apoptosis The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. AA848268_at DnaJ Homolog 5 -1.0 -1.9 -2.2 -1.9 protein turnover; protein folding rc_AA891542_at DnaJ Homolog 5 -2.3 -1.7 -1.5 -1.6 protein turnover; protein folding rc_AI009806_at "Dynein, cytoplasmic, light chain 1" -2.1 -2.0 -1.9 -1.3 cytoskeleton/sarcomere; structural rc_AI233219_at Endothelial cell-specific molecule 1; Pineal specific PG25 protein -1.5 -2.8 -1.7 -1.8 regulatory; growth/proliferation; ECM IGF; cytokine signaling; tumor supressor; secreted growth factor activity insulin-like growth factor binding activity; secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues Z54212_at Epithelial membrane protein 1 -1.2 -1.7 -1.8 -2.0 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor secreted growth factor activity; cell proliferation; development; oncogenesis; differentiation rc_AA924925_at ER transmembrane protein Dri 42 1.0 1.0 2.0 2.1 regulatory; signal transduction rc_AI639510_at "EST, clone rx02430, 3'end" 1.2 1.7 1.4 2.2 unknown rc_AA800168_at "EST, clone UI-R-C2p-rd-d-02-0-UI, 3'end" 1.1 1.2 2.1 1.3 unknown rc_AA800216_at EST189713 -1.3 -2.2 -2.7 -1.6 unknown rc_AA800750_f_at EST190247 1.0 -1.5 -2.1 -2.7 unknown rc_AA893871_at "EST197674 Normalized rat placenta, Bento ESTs, Soares Rattus sp. cDNA clone RPLAM87 3' end, MRNA sequence" 1.2 -1.1 1.6 2.1 unknown rc_AA799457_at ESTs -1.7 -2.1 -2.1 -2.1 unknown rc_AA799570_at ESTs -1.2 -2.0 -2.5 -2.1 unknown rc_AI236601_at ESTs -1.3 -2.0 -1.8 -2.4 unknown rc_AA893280_at ESTs -1.0 -1.5 -2.0 -2.4 unknown rc_AA894304_at ESTs 1.4 1.7 1.9 2.5 unknown rc_AI639035_at ESTs 3.2 1.3 1.1 2.4 unknown rc_AA894092_at ESTs 1.1 -2.5 -3.6 -5.8 unknown rc_AA800218_at ESTs 2.6 2.3 2.4 1.7 unknown rc_AA799971_g_at ESTs 1.1 1.4 1.9 2.0 unknown rc_AA892897_at ESTs 1.1 -1.4 -1.1 -2.5 unknown rc_AA799971_at ESTs 1.1 1.2 1.4 2.1 unknown rc_AA799964_at ESTs 1.4 1.7 2.0 1.5 unknown rc_AA866259_at Ests 2.3 1.1 1.3 1.3 unknown rc_AA799666_g_at ESTs -1.0 -2.3 -2.0 -1.7 unknown rc_AI639163_at ESTs -1.4 -1.5 -1.7 -2.3 unknown rc_H31964_at ESTs 1.4 1.1 1.2 2.0 unknown rc_AI639170_at ESTs 2.2 1.1 1.8 2.1 unknown rc_AI639238_at ESTs 1.9 1.9 2.2 1.9 unknown rc_AI639499_s_at ESTs 1.4 2.4 2.9 2.0 unknown rc_AA799762_g_at ESTs 1.6 1.1 2.2 1.2 unknown rc_AA800197_at ESTs 1.3 1.6 2.6 1.0 unknown rc_AA892500_at ESTs 1.3 1.6 2.6 1.7 unknown rc_AA891054_at ESTs 1.3 2.2 2.5 3.1 unknown rc_AA893208_at ESTs 2.3 -1.1 1.5 1.1 unknown rc_AA875132_at ESTs -1.1 1.7 3.1 6.8 unknown rc_AI639294_at ESTs 1.1 2.1 2.1 1.2 unknown rc_AA892280_at ESTs 2.8 2.1 2.4 1.6 unknown rc_AI233365_at ESTs 2.0 1.4 1.7 1.8 unknown X07551cds_s_at Ests 1.1 1.5 2.0 1.9 uknown rc_AA875390_at ESTs -3.4 6.4 4.0 -2.2 unknown rc_AA875032_at ESTs 1.3 1.8 2.1 1.1 unknown rc_AA891818_at ESTs -1.4 -2.1 -1.8 -2.1 unknown rc_AA892531_at ESTs 1.2 1.4 2.1 2.0 unknown rc_AA892549_at ESTs 2.3 1.1 1.9 3.1 unknown rc_AA859536_at ESTs -1.1 -1.6 -1.5 -2.2 unknown rc_AA858607_at ESTs 1.5 1.4 2.6 2.1 unknown rc_AA893043_at ESTs 1.0 -1.4 -1.5 -2.6 unknown rc_AI231778_at ESTs 2.6 1.8 1.8 1.8 unknown rc_AA799467_at ESTs 1.8 2.3 1.9 1.8 unknown rc_AA892353_at Ests -1.3 1.7 2.2 1.6 unknown rc_AA892325_at "ESTs, Highly similar to choline/ethanolaminephosphotransferase [Homo sapiens] [H.sapiens]" 1.6 -1.0 4.0 1.4 unknown rc_AI639088_s_at "ESTs, similar to RNA imprinted and accumulated in nucleus (mouse)" -1.3 -4.1 -3.1 -3.0 unknown rc_AA818726_at "ESTs, Weakly similar to CYPM_RAT Peptidyl-prolyl cis-trans isomerase, mitochondrial precursor (PPIase) (Rotamase) (Cyclophilin F) [R.norvegicus]" 1.3 2.2 1.6 1.6 unknown rc_AA800808_at "ESTs, Weakly similar to S12207 hypothetical protein (B2 element) - mouse [M.musculus]" 1.7 2.4 1.4 -1.7 unknown U59241_at E-Tropomodulin 1.4 2.9 4.7 4.1 contraction; unclassified; cytoskeleton/sarcomere X96426_at eukaryotic elongation factor 2 kinase 1.7 1.3 2.3 2.3 protein turnover; translation; inhibitor IGF rc_AI059692_s_at eukaryotic elongation factor 2 kinase 1.7 2.3 2.7 2.1 protein turnover; translation; inhibitor IGF U05014_at eukaryotic translation initiation factor 4E binding protein 1 2.2 2.7 6.4 1.8 protein turnover; translation; inhibitor IGF U05014_g_at eukaryotic translation initiation factor 4E binding protein 1 1.4 2.3 3.8 1.7 protein turnover; translation; inhibitor IGF J02773_at "Fatty acid binding protein, heart" -1.3 -4.3 -3.2 -5.1 metabolism; lipid; uptake and transport X13527cds_s_at fatty acid synthase 1.5 1.1 -1.2 2.1 metabolism; lipid; FA oxidation rc_AI236284_s_at "Fatty acid-Coenzyme A ligase, long chain 4" 1.6 2.2 3.5 1.8 metabolism; lipid biosynthesis D85189_at "Fatty acid-Coenzyme A ligase, long chain 4" -1.0 2.3 2.3 1.6 metabolism; lipid biosynthesis X14323cds_g_at "Fc receptor, IgG, alpha chain transporter" 1.7 2.2 2.4 2.3 stress; immune; antigen X56551cds_at fibroblast growth factor 7 2.3 1.8 1.7 3.2 regulatory; growth/proliferation; secreted growth factor secreted growth factor activity; positive regulation of cell proliferation; differentiation rc_AA799773_g_at "Filamin, gamma-, EST (human)" -1.6 -2.2 -1.4 -1.5 regulatory; cytoskeletal regulator cytoskeletal organization rc_AA799773_at "Filamin, gamma-, EST (human)" -1.7 -2.3 -1.3 -1.2 regulatory; cytoskeletal regulator cytoskeletal organization rc_AA858520_g_at Follistatin 1.4 2.4 3.7 2.8 regulatory; growth/proliferation;growth factor; TGF-beta; secreted growth factor activity; SMAD; TGFbeta receptor signaling pathway rc_AA849769_g_at Follistatin related protein precursor -1.3 -1.7 -2.2 -1.5 regulatory; growth/proliferation;growth factor; TGF-beta; secreted growth factor activity; SMAD; TGFbeta receptor signaling pathway rc_H31144_g_at formin 2; EST (mouse) 1.5 1.7 2.1 2.1 cytoskeleton/sarcomere; structural rc_AA891527_at Four and a half LIM domains 2 (Slim3) -5.9 -3.5 -3.7 -4.6 regulatory; adhesion differentiation; NFKB; IGF; adhesion; LIM; myogenesis AJ005046_g_at "Fructose bisphosphatase 2, muscle" 1.2 -1.0 2.0 6.4 metabolism; carbohydrate; glycolytic X15580complete_seq_s_at "fructose-2,6-bisphosphatase 1" 2.5 3.8 3.7 5.3 metabolism; carbohydrate; glycolytic J04197_i_at "fructose-2,6-bisphosphatase 1" 1.9 1.8 1.2 3.2 metabolism; carbohydrate; glycolytic L26292_g_at FSH-regulated 1.2 -3.7 -2.5 -2.1 regulatory; growth/proliferation; growth factor activity M77694_at Fumarylacetoacetate hydrolase 2.0 1.7 2.0 2.1 protein turnover; metabolism; protein; amino acid AB016161cds_r_at "gamma-aminobutyric acid (GABA) B receptor, 1" 1.2 1.5 2.4 1.5 regulatory; signal transduction adenylate cyclase activity; gamma-amino butyric acid signaling pathway; synaptic; metabotropic glutamate receptor signaling pathway AF080468_g_at "Glucose-6-phosphatase, transport protein 1" 1.8 2.6 1.8 1.6 metabolism; carbohydrate; glycolytic AF080468_at "Glucose-6-phosphatase, transport protein 1" 1.5 2.3 1.4 1.9 metabolism; carbohydrate; glycolytic S63521_i_at Glucose-regulated protein GRP78 -1.6 -8.8 -3.3 -4.5 protein turnover; protein folding M90518_at "Glutamate receptor, metabotropic 4" -1.4 -1.6 -2.3 -1.0 regulatory; signal transduction "cAMP responsive; G-protein coupled receptor protein signaling pathway; synaptic transmission; metabotropic glutamate, GABA-B-like receptor activity; negative regulation of adenylate cyclase activity" Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities M91652complete_seq_g_at Glutamine synthetase glutamate-ammonia ligase 1.3 3.4 6.9 3.5 protein turnover; metabolism; protein; amino acid rc_AA852004_s_at Glutamine synthetase glutamate-ammonia ligase 1.1 3.4 7.2 3.7 protein turnover; metabolism; protein; amino acid M91652complete_seq_at Glutamine synthetase glutamate-ammonia ligase -1.1 4.2 9.6 4.4 protein turnover; metabolism; protein; amino acid rc_AI232783_s_at Glutamine synthetase glutamate-ammonia ligase 1.0 2.1 4.9 3.3 protein turnover; metabolism; protein; amino acid X07365_s_at Glutathione peroxidase 1 -1.4 -4.0 -3.9 -2.0 stress; oxidative/toxic X12367cds_s_at Glutathione peroxidase 1 -1.3 -3.0 -3.5 -1.9 stress; oxidative/toxic D00680_at "glutathione peroxidase precursor, plasma" 1.2 1.6 1.9 2.2 stress; oxidative/toxic E01415cds_s_at Glutathione-S-transferase 1.3 2.6 1.9 1.5 stress; oxidative/toxic rc_AA892234_at "Glutathione-S-transferase 3, EST (human)" -1.1 -2.0 -3.8 -2.3 stress; oxidative/toxic U86635_at Glutathione-S-transferase mu 5 1.6 2.7 3.0 2.8 stress; oxidative/toxic U86635_g_at Glutathione-S-transferase mu 5 1.7 2.3 2.7 2.6 stress; oxidative/toxic K01932_f_at "Glutathione-S-transferase, alpha type (Ya)" 1.7 4.4 3.4 2.0 stress; oxidative/toxic X78848cds_f_at "Glutathione-S-transferase, alpha type (Ya)" 2.0 2.7 3.7 2.5 stress; oxidative/toxic S72505_f_at "Glutathione-S-transferase, alpha type (Ya)" 3.2 6.2 6.6 2.9 stress; oxidative/toxic J03914cds_s_at "glutathione-S-transferase, mu type 2 (Yb2)" 1.5 3.2 5.3 5.6 stress; oxidative/toxic X04229cds_s_at "glutathione-S-transferase, mu type 2 (Yb2)" 1.7 2.7 2.9 2.1 stress; oxidative/toxic J02592_s_at "glutathione-S-transferase, mu type 2 (Yb2)" -1.1 3.1 3.5 6.6 stress; oxidative/toxic H32189_s_at "glutathione-S-transferase, mu type 2 (Yb2)" 1.0 2.0 2.2 1.9 stress; oxidative/toxic U36772_at Glycerol-3-phosphate acyltransferase 1.3 1.6 2.3 1.5 metabolism; lipid; thermogenesis U36773_g_at "glycerol-3-phosphate acyltransferase, mitochondrial " 1.7 1.4 2.2 -1.2 metabolism; lipid; thermogenesis X78593_at glycerol-3-phosphate dehydrogenase 2 2.0 2.9 1.4 1.4 metabolism; carbohydrate; glycolytic U83880UTR#1_at glycerol-3-phosphate dehydrogenase 2 1.6 2.0 5.0 4.9 metabolism; carbohydrate; glycolytic L10669_g_at Glycogen phosphorylase muscle isozyme 1.5 2.4 3.3 2.9 metabolism; carbohydrate; glycogenolysis L10669_at Glycogen phosphorylase muscle isozyme 1.4 2.2 2.9 2.6 metabolism; carbohydrate; glycogenolysis L10326_at GNAS complex locus -1.0 1.5 2.2 1.6 regulatory; vesicle transport GTP signaling; intracellular trafficking; adenylate cyclase activation U77829mRNA_i_at growth arrest specific 5 1.5 2.1 1.5 1.2 regulatory; growth/proliferation; proliferation; cell cycle arrest cell cycle arrest; differentiation; development U77829mRNA_s_at growth arrest specific 5 1.5 2.7 1.5 -1.0 regulatory; growth/proliferation; proliferation; cell cycle arrest cell cycle arrest; differentiation; development AF076619_at Growth factor receptor bound protein 14 1.3 2.0 1.8 1.4 regulatory; growth/proliferation; growth factor activity SH3; SH2; neuropeptide signaling pathway; secreted growth factor activity S49003_s_at "Growth hormone receptor, short isoform" -1.2 6.5 1.4 3.9 regulatory; growth/proliferation; growth factor activity secreted growth factor activity D13417_g_at Hairy-related and enhancer of split 1 1.8 2.6 2.0 1.7 regulatory; transcription adhesion; development; Ebox; neurogenesis; Notch signaling; myogenesis D29960_at Heat shock 20-kDa protein -1.3 -3.8 -3.4 -2.7 protein turnover; protein folding rc_AI103838_g_at Heat shock 20-kDa protein -1.5 -4.4 -3.3 -2.6 protein turnover; protein folding M86389cds_s_at Heat shock 27kD protein 1 -2.1 -1.3 1.2 -1.9 protein turnover; protein folding AF077354_g_at heat shock 70 kDa protein 4 -1.2 -1.9 -1.9 -2.3 protein turnover; protein folding M14050_s_at heat shock 70kD protein 5 -2.1 -2.7 -1.8 -2.2 protein turnover; protein folding L16764_s_at Heat shock protein 70 -3.4 -3.6 -2.8 -2.1 protein turnover; protein folding Z75029_s_at Heat shock protein 70 -5.0 -3.2 -1.9 -1.3 protein turnover; protein folding Z27118cds_s_at Heat shock protein 70 -6.1 -3.2 -2.3 -2.0 protein turnover; protein folding rc_AA818604_s_at Heat shock protein 70 -3.1 -2.8 -2.4 -1.9 protein turnover; protein folding AA848563_s_at Heat shock protein 70 -4.0 -5.6 -12.8 -7.4 protein turnover; protein folding rc_AI176546_at Heat shock protein 90 beta -3.0 -2.1 -2.3 -2.8 protein turnover; protein folding AA108277_at "Heat shock protein E71, 5' similar to hsp-E7I" -1.7 -2.2 -1.9 -2.7 protein turnover; protein folding rc_AA875531_s_at "Heat shock protein, 60 kDa" 1.1 -1.3 -1.9 -2.1 protein turnover; protein folding S56464mRNA_at Hexokinase II -1.3 -1.1 2.0 2.0 metabolism; carbohydrate; glycolytic D26393exon_s_at Hexokinase II -1.9 1.2 1.7 2.2 metabolism; carbohydrate; glycolytic rc_AI007857_at HGF-regulated tyrosine kinase substrate (Hrs) -1.2 2.0 2.0 1.4 regulatory; growth/proliferation; proliferation; negative intracellular trafficking; zinc ion binding activity; Src; endosome; negative regulation of cell proliferation; differentiation rc_AA892014_s_at HLA-B associated transcript 1 (Bat1) 1.4 1.3 1.8 2.2 regulatory; mRNA processing DEAD RNA helicase AB007689_at "homer, neuronal immediate early gene 2" -1.1 -3.1 -4.8 -5.3 regulatory; signal transduction metabotropic glutamate receptor signaling pathway; GKAP/Homer scaffold activity AB007690_s_at "homer, neuronal immediate early gene 2" -1.4 -3.2 -8.6 -13.7 regulatory; signaling metabotropic glutamate receptor signaling pathway; GKAP/Homer scaffold activity M65251_s_at Human immunodeficiency virus type I enhancer-binding protein 2 1.2 1.6 2.0 2.1 regulatory; transcription metal ion binding activity X96437mRNA_g_at immediate early response 3 (IEX-3 or Prg1) 3.4 2.1 2.2 1.1 regulatory; transcription apoptosis inhibitor; cAMP responsive This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. rc_AA799566_g_at incisor protein 1.7 6.2 3.7 3.3 regulatory; transcription DNA repair; stress or injury L23148_g_at "Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)" -1.6 -2.9 -2.1 -2.6 regulatory; transcription SMAD; development; Ebox; myogenesis M31837_at insulin-like growth factor binding protein 3 1.5 1.3 2.6 1.2 regulatory; growth/proliferation; growth factor activity; IGF; secreted growth factor activity; myogenesis M62781_at Insulin-like growth factor-binding protein 5 3.7 3.0 8.4 4.1 regulatory; growth/proliferation; growth factor activity IGF; secreted growth factor activity; myogenesis rc_AI029920_s_at Insulin-like growth factor-binding protein 5 4.7 2.8 6.0 4.3 regulatory; growth/proliferation; growth factor activity; IGF; secreted growth factor activity; myogenesis U69272_at Interleukin 15 2.2 2.0 2.1 3.0 regulatory; growth/proliferation; growth factor activity; positive apoptosis; secreted growth factor activity; cytokine signaling; endosome; JAK-STAT "This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6." AF015719_s_at Interleukin 15 3.8 1.9 1.4 1.6 regulatory; growth/proliferation;proliferation; positive apoptosis; secreted growth factor activity; cytokine signaling; endosome; JAK-STAT "This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6." rc_AI176621_at iron-responsive element-binding protein 2.0 2.7 2.5 1.9 regulatory; mRNA processing iron homeostasis; RNA stability rc_AA892314_at "Isocitrate dehydrogenase 1, soluble" 2.0 2.0 2.3 1.4 metabolism; carbohydrate; glycolytic U13396_g_at Janus kinase 2 (a protein tyrosine kinase) 2.3 3.1 2.1 1.2 regulatory; signal transduction JAK-STAT; cytokine signaling; negative regulation of cell proliferation; differentiation M19647_f_at kallikrein 1 1.3 2.1 2.2 -1.2 protein turnover; proteolysis; protease D12769_g_at Kruppel-like factor 9 1.5 1.9 2.2 2.3 regulatory; transcription JNK M54926_at Lactate dehydrogenase A 1.0 1.3 1.8 2.7 metabolism; carbohydrate; glycolytic rc_AA859581_at Late gestation lung protein -1.1 -2.2 -1.6 -1.2 uknown morphogenesis L03294_g_at Lipoprotein lipase -1.1 -2.4 -1.8 -1.7 metabolism; lipid; uptake and transport L03294_at Lipoprotein lipase -1.1 -2.3 -1.8 -1.7 metabolism; lipid; uptake and transport U97146_at Lysophospholipase 1.3 2.4 1.6 1.3 regulatory; signal transduction phosopholipase Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. AF004661_at mannose-binding protein associated serine protease-1 1.3 1.7 2.5 3.4 protein turnover; proteolysis; serine protease D50564_at Mercaptopyruvate sulfurtransferase 1.5 2.5 2.3 1.9 stress; oxidative/toxic rc_AI169327_at "Metalloproteinase-1, tissue inhibitor of-" -1.2 -2.2 -1.4 -2.3 protein turnover; proteolysis; protease inhibitor rc_AI169327_g_at "Metalloproteinase-1, tissue inhibitor of-" -1.3 -12.2 -4.2 -12.4 protein turnover; proteolysis; protease inhibitor M93401_at methylmalonate semialdehyde dehydrogenase gene 1.5 1.8 2.1 1.7 protein turnover; metabolism; protein; amino acid AF095741_g_at Mg87 protein 1.4 2.0 1.6 1.8 unknown X14254cds_at MHC class II-associated invariant chain 2.5 2.6 9.3 7.1 stress; immune; antigen X14254cds_g_at MHC class II-associated invariant chain 1.1 1.5 5.4 2.6 stress; immune; antigen rc_AA957930_s_at Microtubule-associated protein tau -1.0 -1.4 -1.7 -2.1 cytoskeleton/sarcomere; structural rc_AI227608_s_at Microtubule-associated protein tau -1.1 -1.8 -2.9 -5.7 cytoskeleton/sarcomere; structural X79321_at Microtubule-associated protein tau -1.0 -1.4 -1.7 -2.6 cytoskeleton/sarcomere; structural rc_AA799508_at Microtubule-associated proteins 1A/1B light chain 3 1.2 1.6 1.5 2.1 cytoskeleton/sarcomere; structural U05784_s_at Microtubule-associated proteins 1A/1B light chain 3 1.1 2.3 3.2 1.5 cytoskeleton/sarcomere; structural Y09333_at Mitochondrial acyl-CoA thioesterase 1 1.1 -1.9 -1.5 -2.1 metabolism; lipid; FA oxidation rc_AA892400_at "mitochondrial CCA-adding tRNA-nucleotidyltransferase, ESTs (human)" 1.9 2.2 3.3 2.1 unknown U48596_g_at Mitogen activated protein kinase kinase kinase 1; Map3k1 2.3 1.6 1.4 1.5 regulatory; signal transduction MAPK; MEK; JNK; ERK; p38; apoptosis; cytokine signaling rc_AI011376_at "Mitogen-activated protein kinase kinase 2, EST (mouse)" 2.3 2.6 2.8 1.7 regulatory; signal transduction MAPK; MEK; JNK; ERK; p38; apoptosis; cytokine signaling rc_AA955477_g_at "Mitogen-activated protein kinase kinase 2, EST (mouse)" 1.4 2.3 2.3 1.9 regulatory; signal transduction MAPK; MEK; JNK; ERK; p38; apoptosis; cytokine signaling rc_AA925300_at Mitogen-activated protein kinase kinase kinase 3 1.2 1.1 2.1 1.1 regulatory; signal transduction MAPK; MEK; JNK; ERK; p38; apoptosis; cytokine signaling U87627_at Monocarboxylate transporter 1.4 1.8 1.8 3.4 metabolism; carbohydrate; glycolytic X90642mRNA_at Multidrug resistance protein (ID:1) 4.5 5.2 3.7 5.6 unknown X81193_at Muscle LIM protein; cysteine-rich protein -2.3 -3.7 -2.1 -1.9 regulatory; cytoskeletal regulator development; differentiation; myogenesis; LIM rc_AA851223_at Muscle specific enolase (beta beta enolose) 1.1 1.8 2.0 4.1 metabolism; carbohydrate; glycolytic K00512_at Myelin basic protein 1.2 1.2 1.9 2.3 regulatory; PI3k development; Pi3K; neurogenesis AB019393_at myocilin 2.4 2.0 1.3 1.7 regulatory; cytoskeletal regulator cytoskeletal organization M84176_at Myogenic regulatory factor D 3.4 3.5 5.8 3.0 regulatory; transcription development; differentiation; myogenesis S68736_at Myosin heavy chain 2D/2X -1.6 30.0 6.3 59.4 contraction; fast; cytoskeleton/sarcomere X04267_at myosin heavy chain 3 -1.5 -3.0 -6.5 -4.5 contraction; embryonic; cytoskeleton/sarcomere K03468_s_at myosin heavy chain 3 -1.2 -2.6 -4.9 -3.7 contraction; embryonic; cytoskeleton/sarcomere L24897_s_at Myosin heavy chain IIx/d 4.0 25.6 120.7 188.3 contraction; fast; cytoskeleton/sarcomere M12098_s_at "Myosin heavy chain, embryonic" -1.4 -4.5 -21.8 -16.1 contraction; embryonic; cytoskeleton/sarcomere K03467_s_at "Myosin heavy chain, embryonic" -1.5 -3.2 -19.4 -16.2 contraction; embryonic; cytoskeleton/sarcomere X00975_at "Myosin light chain 2, fast" -1.1 1.6 1.4 4.8 contraction; fast; cytoskeleton/sarcomere X00975_g_at "Myosin light chain 2, fast" -1.2 1.6 1.4 5.5 contraction; fast; cytoskeleton/sarcomere M11851_at "Myosin light chain 2, slow" -1.3 -6.2 -23.1 -10.4 contraction; slow; cytoskeleton/sarcomere X07314cds_at "Myosin light chain 2, slow" -1.2 -5.3 -61.3 -12.6 contraction; slow; cytoskeleton/sarcomere X07314cds_g_at "Myosin light chain 2, slow" -1.3 -5.3 -36.1 -7.2 contraction; slow; cytoskeleton/sarcomere J03886_at "Myosin light chain kinase 2, skeletal muscle" 1.4 1.6 2.1 1.9 regulatory; cytoskeletal regulator adhesion; cytoskeletal organization; calcium signaling X05566_i_at Myosin light chain RLC -1.4 -4.5 -3.7 -2.8 contraction; slow; cytoskeleton/sarcomere X54617mRNA_s_at "myosin regulatory light chain, exon 4" -1.4 -3.7 -3.2 -2.2 contraction; slow; cytoskeleton/sarcomere U04937_s_at Na-Ca exchanger; sodium-calcium exchanger -1.6 -2.8 -6.0 -2.9 contraction; slow; membrane depolarization X87157_at Neurolysin (metallopeptidase M3 family) 1.4 1.6 2.3 2.3 protein turnover; proteolysis; protease; S72637_s_at NO3; tumor-suppressive gene 1.2 1.4 1.9 2.1 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor tumor supressor; cell cycle arrest rc_AA799539_at "NS1-binding protein, EST (human)" 2.8 2.4 3.1 2.4 protein turnover; translation; mRNA processing rc_AA891864_at "Nuclear ATP/GTP-binding protein, EST (mouse)" 1.4 1.9 3.5 3.4 regulatory; signal transduction differnetiation; Purkinje cell degeneration; carboxypeptidase; regeneration NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif; Nna1 may contribute to nuclear signaling events in differentiating and regenerating neurons X13167cds_s_at Nuclear Factor IA (Nfia) 1.6 2.2 1.4 -1.1 regulatory; transcription translation regulator activity; cytokine signaling; Y-box binding protein U20796_at "nuclear receptor subfamily 1, group D, member 2" 1.6 2.1 1.4 1.7 regulatory; transcription ligand-dependent nuclear receptor signaling; Rev-ErbA; differentiation; development "In summary, HZF-2 alpha/beta are novel orphan nuclear receptors which may play an important role in hormone-dependent aspects of developmental processes modulating hippocampal and cerebellar plasticity" rc_AI176710_at "nuclear receptor subfamily 4, group A, member 3" -1.6 -1.3 -1.4 -3.1 regulatory; transcription ligand-dependent nuclear receptor signaling; steroid hormone receptor activity; NGFI-B "A cDNA clone of NOR-1 encodes a 68kDa, 628 amino acid residue-containing protein, with an amino acid sequence highly homologous to the Nur77 family in its DNA-binding domain and moderately so in its putative ligand-binding domain. Using mobility shift ass" AF062594_g_at nucleosome assembly protein 1-like 1 1.2 1.6 2.2 1.1 regulatory; growth/proliferation; proliferation; cell cycle; positive positive regulation of cell proliferation This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. U17254_at Nur77; Immediate early gene transcription factor NGFI-B -2.4 -1.4 2.4 1.4 regulatory; transcription ligand-dependent nuclear receptor signaling; NGFI-B rc_AA893325_at ornithine aminotransferase 1.0 2.8 1.2 1.0 protein turnover; metabolism; protein; amino acid J04791_s_at ornitine decarboxylase -3.9 -1.6 -2.3 -2.0 protein turnover; metabolism; protein; amino acid J04792_at ornitine decarboxylase -2.0 -2.0 -2.2 -2.3 protein turnover; metabolism; protein; amino acid rc_AI175539_at Parvalbumin 1.3 3.1 5.7 5.6 contraction; membrane depolarization X62951mRNA_s_at pBUS19 with repetitive elements 1.6 2.5 1.9 1.8 unknown U23769_at PDZ and LIM domain 1 (elfin) -1.9 -3.1 -4.9 -3.0 stress; oxidative/toxic E03344cds_s_at Peroxisomal membrane protein 3 2.1 1.8 2.2 1.5 regulatory; signal transduction peroxisome organization and biogenesis S56508_s_at Phosphatidylinositol 4-kinase 3.9 4.9 6.2 4.3 metabolism; lipid biosynthesis U25651_at "Phosphofructokinase, muscle" 1.4 1.9 2.0 2.4 metabolism; carbohydrate; glycolytic U20195_s_at Phosphoglucomutase 1 1.5 1.7 2.1 2.0 metabolism; carbohydrate; glycogenolysis rc_AA894296_at Phosphoglucomutase 1 1.2 1.7 2.2 1.6 metabolism; carbohydrate; glycogenolysis L11694_at Phosphoglucomutase 1 1.5 1.7 2.4 2.1 metabolism; carbohydrate; glycogenolysis S63233_g_at Phosphoglycerate mutase 1 type B -1.8 -2.1 -2.2 -2.3 metabolism; carbohydrate; glycolytic X51529_at "Phospholipase A2, group IIA" 2.3 1.3 1.3 1.9 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor tumor suppressor; oncogenesis; calcium signaling; stress or injury M20637_s_at "Phospholipase C, delta 1" 1.3 2.2 2.3 2.1 regulatory; signal transduction calcium signaling U16655_at "Phospholipase C, delta 4" 2.0 2.8 1.8 1.9 regulatory; signal transduction calcium signaling M98826mRNA_g_at "Phosphorylase kinase, gamma" 1.1 2.5 2.9 3.8 metabolism; carbohydrate; glycogenolysis X07320_at "Phosphorylase kinase, gamma 1" 1.2 2.0 2.5 2.9 metabolism; carbohydrate; glycogenolysis rc_AI639151_at "pinin, ESTs (mouse)" 1.9 1.1 2.2 1.4 cytoskeleton/sarcomere; structural rc_AA891842_at Podocalyxin precursor 1.9 1.2 1.1 3.6 unknown X62841mRNA_at potassium channel protein (2858 bp) 1.5 2.4 2.0 2.8 contraction; unclassified; membrane depolarization X78461_at "potassium inwardly-rectifying channel, subfamily J, member 12" -1.3 3.7 2.8 2.2 contraction; unclassified; membrane depolarization U61729_at proline rich 2 1.3 1.6 2.4 1.5 protein turnover; proteolysis; ubiquitination L17318_at proline-rich proteoglycan 2 1.2 1.5 1.0 2.8 regulatory; growth/proliferation; ECM D16443_g_at Prostaglandin E receptor 3 ( subtype EP3) -1.0 1.0 -1.1 2.1 regulatory; growth/proliferation; growth factor activity; cAMP responsive; GTP signaling; thermogenesis D50694_at "Proteasome (prosome, macropain) 26S subunit, ATPase" 1.0 2.1 1.7 1.1 protein turnover; proteolysis; protease; proteasome subunit; U77918_at "Proteasome 26S subunit, ATPase 3" 1.0 2.2 1.8 1.1 protein turnover; proteolysis; protease; proteasome subunit; D50695_at "Proteasome 26S subunit, ATPase 4 (Tat-binding protein)" 1.1 2.5 1.8 1.1 protein turnover; proteolysis; protease; proteasome subunit; AB000491_at "Proteasome 26S subunit, ATPase 5 (SUG1)" 1.1 2.3 2.0 1.7 protein turnover; proteolysis; protease; proteasome subunit; AJ006340_s_at "Proteasome 26S subunit, p112" 1.2 2.7 2.6 1.7 protein turnover; proteolysis; protease; proteasome subunit; X55986mRNA_s_at "Proteasome subunit, alpha 4" 1.1 2.2 1.7 -1.2 protein turnover; proteolysis; protease; proteasome subunit; L17127_g_at "Proteasome subunit, beta 4 (RN3)" 1.4 2.4 1.3 1.3 protein turnover; proteolysis; protease; proteasome subunit; rc_AI172162_at "Proteasome subunit, beta 4 (RN3)" 1.1 2.2 1.5 1.1 protein turnover; proteolysis; protease; proteasome subunit; U13895_s_at "Proteasome subunit, MSS1" 1.2 2.6 2.1 1.1 protein turnover; proteolysis; protease; proteasome subunit; D26180_at protein kinase C-like 1 1.0 2.2 2.4 1.7 regulatory; signal transduction activation of JUN kinase X89225cds_s_at Protein linked to system L-like neutral amino acid transport activity -1.2 -1.4 -1.3 -2.1 protein turnover; metabolism; protein; amino acid rc_AA799980_at "Protein phosphatase 1B (2C), magnesium-dependent, beta isoform" -1.9 -2.1 -1.2 -1.7 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor differentiation The mRNA level of type 2C protein phosphatase was enhanced in accordance with the differentiation of the C3H10T1/2 cells into myoblasts induced by the transfection of MyoD cDNA. These results suggest that type 2C protein phosphatase is related to the mech rc_AI012595_at "Protein phosphatase 2 (2A), catalytic subunit, alpha isoform" -2.1 -2.5 -1.9 -1.7 regulatory; signal transduction differentiation; insulin Protein phosphatase 2A (PP2A) acts on a number of enzymes involved in the insulin regulation of glucose uptake and glycogen synthesis X16043cds_at protein phosphatase 2A catalytic subunit isotype alpha -1.7 -2.0 -1.6 -1.9 regulatory; signal transduction differentiation; insulin Protein phosphatase 2A (PP2A) acts on a number of enzymes involved in the insulin regulation of glucose uptake and glycogen synthesis S90449_at protein phosphatase 2C -1.5 -1.6 -1.1 -2.1 regulatory; signal transduction L19933_s_at "Protein tyrosine phosphatase, receptor type, D" 1.2 1.5 1.9 2.4 regulatory; proliferation; oncogenesis/tumor supressor; transmembrane receptor; neurogenesis; differentiation; oncogenesis; adhesion L19180_g_at "Protein tyrosine phosphatase, receptor type, D" 1.9 4.5 8.8 4.3 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor transmembrane receptor; neurogenesis; differentiation; oncogenesis; adhesion rc_AA800844_s_at Protein-lysine 6-oxidase -1.3 -1.7 -2.1 -2.3 ECM structrual/regulator rc_AA893235_at "Putative lymphocyte G0/G1 switch protein 2, EST (mouse)" 5.6 2.2 1.6 2.2 regulatory; growth/proliferation; proliferation; cell cycle cell cycle; G0/G1 switch Genes actively involved in the G0/G1 switch (G0S genes) may be differentially expressed during the lectin-induced switch of lymphocytes from the G0 to the G1 phases of the cell cycle X59993_at Putative zinc finger protein 2.0 1.4 2.3 2.8 regulatory; transcription factor U32314_at Pyruvate carboxylase 1.4 1.4 2.3 1.5 metabolism; carbohydrate; glycolytic U10357_at pyruvate dehydrogenase kinase 2 1.4 2.0 2.1 1.5 metabolism; carbohydrate; glycolytic AF034577_at "Pyruvate dehydrogenase kinase, isoenzyme 4" -2.4 -3.2 -1.1 -1.5 metabolism; carbohydrate; glycolytic AF062740_g_at Pyruvate dehydrogenase phosphatase isoenzyme 1 4.3 8.8 3.8 2.7 metabolism; carbohydrate; glycolytic AF062740_at Pyruvate dehydrogenase phosphatase isoenzyme 1 2.1 2.2 2.0 1.6 metabolism; carbohydrate; glycolytic rc_AA818951_at Pyruvate kinase 3 1.1 1.6 2.3 3.0 metabolism; carbohydrate; glycolytic D01046_at "Rab11b, member RAS oncogene family" 1.4 1.4 2.7 2.0 regulatory; signal transduction intracellular trafficking; GTP signaling; Ras U12187_at Ras-related associated with diabetes -5.0 -2.0 -2.6 -2.1 regulatory; signal transduction GTP signaling M10934_s_at Retinol-binding protein (RBP) 1.7 1.8 1.1 2.2 unknown "carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision" rc_AI175486_at Ribosomal protein S7 -1.1 1.7 1.7 2.2 protein turnover; translation; ribosomal protein U25746_at RNA helicase with arginine-serine-rich domain 1.5 2.1 1.1 1.4 protein turnover; translation; mRNA processing U25746_g_at RNA helicase with arginine-serine-rich domain 1.3 2.1 1.8 1.4 protein turnover; translation; mRNA processing rc_AI228548_at "S-100 protein, alpha chain " 1.6 1.3 1.3 2.0 regulatory;adhesion calcium signaling; cel cycle; differnetiation; PKC; cytoskeleton "This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies." M14656_at Secreted phosphoprotein 1 -1.6 -2.5 -1.2 -2.2 regulatory; growth/proliferation; ECM rc_AI230247_s_at "Selenoprotein P, plasma, 1" 1.4 2.2 1.5 1.4 stress; oxidative/toxic M69246_at "Serine (or cysteine) proteinase inhibitor, clade H, member 1; Collagen binding protein" -1.9 -2.0 -2.0 -1.5 protein turnover; proteolysis; protease inhibitor rc_AA799791_at "serine/threonine kinase 25, ESTs (yeast)" 1.4 1.4 2.6 -1.4 regulatory; signal transduction cAMP responsive; PKC; oxidative stress Y07534cds_s_at Serpin; Serine protease inhibitor; mitochondrial cytochrome P450 3.8 14.4 15.5 6.6 protein turnover; proteolysis; protease inhibitor M38566mRNA_s_at Serpin; Serine protease inhibitor; mitochondrial cytochrome P450 2.4 7.3 8.1 3.4 protein turnover; proteolysis; protease inhibitor U25281_at SH3 domain binding protein CR16 2.0 1.7 2.3 5.5 regulatory; signal transduction SH3; cytoskeletal organization X91988_at Signal transducer and activator of transcription 5b 1.6 1.6 2.6 1.5 regulatory; transcription cytokine signaling; JAK-STAT X62950mRNA_f_at similar to protease [Sus scrofa] 2.5 2.1 1.3 1.4 protein turnover; proteolysis D37934_g_at "Sirtuin 2 (silent mating type information regulation 2, homolog) 2" 1.1 2.8 1.5 1.3 regulatory; transcription chromatin silencing yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. S82383_s_at slow-twitch alpha TM/hTMnm homolog -1.9 -1.5 -1.8 -2.1 contraction; slow; cytoskeleton/sarcomere rc_AA891969_at Small Unique Nuclear hormone receptor CoRepressor (C1D) 1.4 2.0 1.7 1.6 regulatory; transcription myogenesis; differentiation; ligand-dependent nuclear receptor signaling We conclude that SUN-CoR is a corepressor and may function as an additional component of the complex involved in transcriptional repression by unliganded and orphan nuclear hormone receptors. M22253_at "Sodium channel, voltage-gated, type 1, alpha polypeptide" -4.8 -1.2 -9.3 -1.0 ion transport; sodium/potassium AF051561_s_at "Solute carrier family 12, member 2" 2.3 2.3 1.2 1.4 ion transport; sodium/chloride-potassium/chloride L19931_at "Solute carrier family 20, member 2" 1.5 1.6 2.5 1.6 ion transport; sodium/phosphate symporter AB015433_s_at "solute carrier family 3, member 2" -1.4 -2.0 -1.9 -3.4 protein turnover; metabolism; protein; amino acid U50927_at "Solute carrier family 30 (zinc transporter), member 2" 1.1 2.0 2.7 1.1 regulatory; vesicle transport endosome; synaptic; zinc binding activity J05167_at Solute carrier family 4 member 3 anion exchange protein 3; Cl-/HCO3- exchanger (B3RP3) 1.0 -2.7 -3.1 -2.7 ion transport; sodium/phosphate symporter J05166_g_at "Solute carrier family 4, member 2" 1.9 1.5 2.6 1.4 ion transport inorganic anion exchanger activity; pH regulation; oxidative stress rc_AI237576_s_at SPA-1 like protein p1294 1.1 1.6 -2.6 -1.3 regulatory; signal transduction cytoskeletal organization; NMDA; GTPase activating L13635_s_at "Splicing factor, arginine/serine-rich 5" 1.8 1.6 2.2 1.9 protein turnover; translation; mRNA processing AB014722_at squamous cell carcinoma antigen recognized by T-cells 1 2.0 1.3 1.4 1.8 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor oncogenesis; tumor supressor J02585_at Stearoyl-Coenzyme A desaturase 1 3.3 5.8 2.0 6.9 metabolism; lipid; FA oxidation rc_AI230712_at Subtilisin - like endoprotease 1.3 1.2 1.3 2.1 protein turnover; proteolysis; protease AF065161_at Suppressor of cytokine signaling (SOCS-1) (Cish1) 3.0 1.3 1.9 1.6 regulatory; signal transduction cytokine signaling; JAK-STAT; MAPK; IGF; apoptosis "The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling" AF075382_at Suppressor of cytokine signaling-2 (SOCS-2) (Cish2) 2.3 7.5 1.6 1.7 regulatory; signal transduction cytokine signaling; JAK-STAT; MAPK; IGF; apoptosis "The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling" rc_AI639484_at Synaptic vesicle glycoprotein 2b 10.8 3.2 1.2 2.6 regulatory; vesicle transport development S45663_at Synaptic vesicle glycoprotein Sc2 1.2 -1.5 -2.1 -1.8 regulatory; growth/proliferation; growth factor development; synaptic S61868_g_at Syndecan-4 -2.2 -1.6 -1.2 -1.3 regulatory; adhesion adhesion X86789_at "synuclein, gamma" 1.3 1.8 2.8 5.5 regulatory; growth/proliferation; proliferation; oncogenesis/tumor supressor oncogenesis D89730_at T16 1.7 2.2 1.8 1.9 unknown rc_AA800962_at Talin; ESTs (mouse) -1.2 -3.9 -1.3 -1.3 regulatory; adhesion adhesion U89282_at Telomerase protein component 1 1.4 1.8 2.1 1.6 regulatory; transcription chromatin X15705cds_at Testis-specific heat shock protein-related gene hst70 -2.1 -2.3 -2.5 -1.7 protein turnover; protein folding rc_AI172476_at TGF-B inducible early growth response 1.8 2.5 2.8 1.9 regulatory; transcription SMAD; TGFbeta receptor signaling pathway TIEG amplies Smad signaling. rc_AI014169_at "Thioredoxin interacting factor; Vdup1 upregulated by 1,25-dihydroxyvitamin D-3" 1.6 2.4 1.7 1.5 stress; oxidative/toxic rc_AI237654_at "Thioredoxin interacting factor; Vdup1 upregulated by 1,25-dihydroxyvitamin D-3" 1.6 2.1 2.2 1.8 stress; oxidative/toxic X56228_at Thiosulfate sulphurtransferase (rhodanese) 1.5 2.0 3.2 2.0 stress; oxidative/toxic X56228_g_at Thiosulfate sulphurtransferase (rhodanese) 4.3 6.9 7.4 3.4 stress; oxidative/toxic K01934mRNA#2_at "Thrsp, thyroid hormone responsive SPOT14 homolog (Rattus)" 2.1 4.3 1.1 8.2 regulatory; signal transduction possible involvement in human lipid disorders; Identification of genes enhanced by protein-calorie malnutrition L14463_at Transducin-like enhancer of split 4 (E(sp1) homolog; EST (rat) 1.4 1.3 2.4 1.3 regulatory; transcription development; differentiation; Notch signaling; myogenesis rc_AA875084_at Transducin-like enhancer of split 4 (E(sp1) homolog; EST (rat) 2.4 3.0 3.6 3.2 regulatory; transcription development; differentiation; Notch signaling; myogenesis M58040_at Transferrin receptor 3.0 -1.7 -1.8 -1.7 stress; oxidative/toxic M83107_at "Transgelin, SM22 alpha" -3.7 -4.3 -2.5 -1.7 regulatory; cytoskeletal regulator cytoskeletal organization M83107_g_at "Transgelin, SM22 alpha" -2.2 -2.8 -1.6 -1.7 regulatory; cytoskeletal regulator cytoskeletal organization Y13275_at Transmembrane 4 superfamily member; tetraspanin 1.1 1.2 4.5 5.1 regulatory; signal transduction adhesion AB006914_at "Trip 10, thyroid hormone receptor interactor 10" 1.3 1.5 2.1 1.7 regulatory; cytoskeletal regulator cytoskeletal organization; SH3 M15474cds_s_at Tropomyosin 1 (alpha) 1.2 2.4 1.8 9.7 contraction; fast; cytoskeleton/sarcomere M34134_s_at Tropomyosin 1 (alpha) 1.1 2.2 1.8 6.4 contraction; fast; cytoskeleton/sarcomere X02412_at Tropomyosin 3 alpha -1.1 1.1 1.5 5.3 contraction; unclassified; cytoskeleton/sarcomere rc_AA799680_at "tropomyosin, alpha-; EST (rat)" 1.7 1.9 1.9 2.3 contraction; fast; cytoskeleton/sarcomere rc_AI639532_at "Troponin C, fast skeletal EST (mouse)" 1.0 2.1 2.4 9.5 contraction; fast; cytoskeleton/sarcomere M73701_at "Troponin I, skeletal, fast 2" 1.0 2.7 1.8 12.9 contraction; fast; cytoskeleton/sarcomere J04993_at "Troponin I, skeletal, slow 1" -1.2 -2.4 -2.4 -2.2 contraction; slow; cytoskeleton/sarcomere rc_AI136540_at "Troponin T, fast skeletal" -1.0 2.5 1.7 8.6 contraction; fast; cytoskeleton/sarcomere rc_AA800948_at Tubulin alpha-1 chain; EST (rat) -3.1 -4.3 -4.9 -1.0 cytoskeleton/sarcomere; structural rc_AA799591_at "Tubulin, beta-, EST (rat)" -2.0 -2.3 -1.6 -1.2 cytoskeleton/sarcomere; structural rc_AA799641_g_at "tumor differentially expressed 1, ESTs (mouse)" 1.4 1.7 1.1 2.5 unknown D17296_at Ubiquitin C 2.0 2.1 2.4 1.5 protein turnover; proteolysis; ubiquitination rc_AI639312_at Ubiquitin-protein ligase E3 (Atrogin1) 1.9 2.0 3.0 1.8 protein turnover; proteolysis; ubiquitination U50842_at Ubiquitin-protein ligase E3 (Nedd4) 2.2 2.5 2.9 1.7 protein turnover; proteolysis; ubiquitination AF035943_at "Uncoupling protein 3, mitochondrial " 1.4 -1.1 2.6 1.2 ion transport; hydrogen U58858_at unction plakoglobin 1.7 1.6 1.9 2.1 regulatory; cytoskeletal regulator cytoskeletal organization X84997mRNA#5_at Variable coding sequence A1 -2.0 -5.9 -1.5 -2.5 unknown M32167_g_at Vascular endothelial growth factor-A188 -1.4 -2.3 -1.6 -1.7 regulatory; growth/proliferation; growth factor activity; positive positive regulation of cell proliferation U96490_at Yip1p-interacting factor -1.1 -2.7 -1.5 -1.3 regulatory; signal transduction GTP signaling; intracellular trafficking