Journal Articles (Neuroscience)

23. Krishnakanth Kondabolu, Erik A Roberts, Mark Bucklin, Michelle M McCarthy, Nancy Kopell, Xue Han. Striatal Cholinergic Interneurons Generate Beta and Gamma Oscillations in the Corticostriatal Circuit and Produce Motor Deficits, PNAS 2016 May 31;113(22):E3159-68.

22. Kohman RE, Cha SS, Man HY, Han X. Light-Triggered Release of Bioactive Molecules from DNA Nanostructures. Nano Letters, 2016 PDF for academic use

21. Rueckemann JW, DiMauro AJ, Rangel LM, Han X, Boyden ES, Eichenbaum H. Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons. Hippocampus. 2016

20. Ali I. Mohammed, Howard J. Gritton, Hua-an Tseng, Mark E. Bucklin, Zhaojie Yao & Xue Han. An integrative approach for analyzing hundreds of neurons in task performing mice using wide-field calcium imaging  Scientific Reports, 2016 PDF  (Download Matlab package)

19. Bleier BS, Kohman RE, Guerra K, Nocera AL, Ramanlal S, Kocharyan AH, Curry WT, Han X. Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier. Neurosurgery, 2015

18. Sayeg, Marianna; Weinberg, Benjamin; Cha, Susie; Goodloe, Michael; Wong, Wilson; Han, Xue. “Rationally designed microRNA-based genetic classifiers target specific neurons in the brain“. ACS Syn Bio, 2015 PDF (Request Plasmids from Addgene)

17. Richie E. Kohman, and Xue Han. “Light-Sensitization of DNA Nanostructures via Incorporation of Photo-Cleavable Spacers.” Chem. Commun. 2015. PMID: 25720373 PDF,  Download: caDNAno file for the spheres

16. Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014. PMID: 25077554

15. Chuong, A. S., Miri, M. L.*, Busskamp, V.*, Matthews, G.A.C.*, Acker, L.C.*, Soresnsen, A.T., Young, A., Klapoetke, N. C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S. B., Bandler, R. C., Allen, B. D., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, R., Cardin, J.A., Boyden, E. S. Noninvasive optical inhibition with a red-shifted microbial rhodopsin, Nature Neuroscience (2014) PMID: 24997763 PDF

14. Zhang XX, LaManna CM, Kohman RE, Mclntosh TJ, Han X, Grinstaff MW, Lipid-mediated DNA and siRNA transfection efficiency depends on peptide headgroup, Soft Matter (2013) PDF

13. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X, Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain, Plos One (2013) PDF

12.  Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ 3rd, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. (2012) PDF

11.  M. M. McCarthy, C. Moore-Kochlacs, X. Gu, E. S. Boyden, X. Han, and N. Kopell, Striatal origin of the pathologic beta oscillations in Parkinson’s disease, PNAS  108:11620-11625 (2011) PDF

10.  Han, X.*, Chow, B. Y.*, Zhou, H., Klapoetke, N. C., Chuong, A., Rajimehr, R., Yang, A., Baratta, M. V., Winkle, J., Desimone, R., Boyden, E. S. (2011) A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Frontiers in Systems Neuroscience. 5:18. doi: 10.3389/fnsys.2011.00018 (2011) (* co-first authors) PDF

9.  Lindskog, M., Li, L., Groth R.D., Poburko, D., Thiagarajan, T.C.,  Han, X., and Tsien, R.W. Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity, PNAS 107:21806-11  (2010) PDF

8.  Chow, B. Y.*, Han, X.*, Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., Boyden, E. S. High-performance genetically targetable optical neural silencing by light-driven proton pumps, Nature 463:98-102. (2010), (* co-first authors) PDF

7.  Xue Han, Sherry X. Xian, and Tirin Moore, “Dynamic sensitivity of area V4 neurons during saccade preparation”, PNAS 106(31):13046-51 (2009) PDF

6.  Xue Han, Xiaofeng Qian, Jacob G. Bernstein, Hui-hui Zhou, Giovanni Talei Franzesi, Patrick Stern, Roderick T. Bronson, Ann M. Graybiel, Robert Desimone and Edward S. Boyden, “Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain,” Neuron 62(2):191-8 (2009) PDF

5.  Xue Han, Xiaofeng Qian, Patrick Stern, Amy Chuong and Edward S. Boyden, “Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions”, Front. Mol. Neurosci 2, 12, (2009) PDF

4.  Xue Han and Edward S. Boyden. “Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution.” PLoS ONE, 2(3):e299. (2007) PDF

3.  Xue Han and Meyer B. Jackson. “Structural Transitions in the Synaptic SNARE Complex during Calcium triggered exocytosis.”J Cell Biol. 172(2): 281-93 (2006) PDF

2.  Xue Han and Meyer B. Jackson. “Electrostatic interactions between the syntaxin membrane anchor and neurotransmitter passing through the fusion pore.” Biophys J. 88 (3): L20-2 (2005) PDF

1.  Xue Han, Chih-Tien Wang, Jihong Bai, Edwin R. Chapman and Meyer B. Jackson. Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.” Science 304 (5668): 289-92 (2004) PDF


Journal Articles (Mucosa Drug Delivery)

7. Nocera AL, Meurer AT, Miyake MM, Sadow PM, Han X, Bleier BS. Secreted P-glycoprotein is a noninvasive biomarker of chronic rhinosinusitis. Laryngoscope. 2016 Aug 31.  PMID: 27577924.

6. Nocera AL, Meurer AT, Singleton A, Simons C, BuSaba J, Tara Gass N, Han X, Bleier BS. Intact soluble P-glycoprotein is secreted by sinonasal epithelial cells. Am J Rhinol Allergy. 2016 Jul;30(4):246-9. PMID: 27456593.

5. Bleier BS, Singleton A, Nocera AL, Kocharyan A, Petkova V, Han X. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. Int Forum Allergy Rhinol. 2016 Feb;6(2):169-77.  PMID: 26625351.

4. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015. PMID: 25330767.

3. Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014. PMID: 25145685.

2. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. (2014)

1. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X, P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells, Int Forum Allergy Rhinol. (2013) PDF


Review Articles
3.  Xue Han, In vivo Application of Optogenetics for Neural Circuit Analysis. ACS Chem. Neurosci. (2012) PDF

2.  Brian Y. Chow, Xue Han, Edward S. Boyden, Genetically encoded molecular tools for light-driven silencing of targeted neurons, Prog Brain Res, 196:49-61, (2012) PDF

1.  Xue Han, Optogenetics in the nonhuman primate, Prog Brain Res, 196:215-33, (2012) PDF


Book Chapters

6. Kondabolu K, Kowalski MM, Roberts EA, Han X. Optogenetics and deep brain stimulation neurotechnologies. Handb Exp Pharmacol. 2015;228:441-50. PMID: 25977092. (2015)

5. Richie Kohman, Hua-an Tseng, and Xue Han (2014) “Optogenetics” The OMICs, Applications in Neuroscience, Oxford

4. Quach, Allison, Nicholas James, and Xue Han. (2014) “Optogenetics” Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing. Springer New York, 2014. 269-282.

3. Hua-an Tseng, Richie E. Kohman, and Xue Han. “Chapter on Optogenetics” Basic Electrophysiological Methods, Oxford University Press. (2013)

2. Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2011) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, Chapter 6, Photosensitive Molecules for Controlling Biological Function, edited by James J. Chambers and Richard H. Kramer, Neuromethods Series Volume 55, 2011, DOI: 10.1007/978-1-61779-031-7, Humana Press.

1. Boyden, E. S., Han, X., Talei Franzesi, G., Chan, S., Bernstein, J., Qian, X., Li, M. (2009) New Techniques for Investigating Brain Rhythms: Optical Neural Control and Multielectrode Recording,” In: Rhythms of the Neocortex: Where Do They Come From and What Are They Good For? (Kopell N., ed.) pp. 65-75. Washington, DC: Society for Neuroscience.


Conference Papers and Talks (Refereed)

Bernstein, J. G., Han, X., Henninger, M. A., Ko, E. Y., Qian, X., Franzesi, G. T., McConnell, J. P., Stern, P., Desimone, R., and Boyden, E. S. (2008) Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons. Proc Soc Photo Opt Instrum Eng, 6854:68540H.



Light-activated proton pumps and uses thereof. United States Patent Application 12/714,436.

Light-activated ion channel molecules and uses thereof. United States Patent Application 13/295,479

Red-shifted opsin molecules and uses thereof. US patent No. 9500641