John Cardonna

Associate Professor (Chemistry, MSE)

Associate Professor (Chemistry, MSE)

  • Primary Appointment Chemistry
  • Education BA/MA in Chemistry, Johns Hopkins University, 1979
    MA/MPhil/PhD, Columbia University, 1985
    Postdoctoral Fellow, Harvard University, 1985-87
  • Additional Affiliations Division of Materials Science & Engineering
  • Honors and Awards Alfred P. Sloan Foundation Research Award, 1993-95
    Member, American Association for the Advancement of Science, 1988
    Camille and Henry Dreyfus Award for Distinguished Faculty in Chemistry, 1987
    NIH Postdoctoral Fellowship, Harvard University, 1985 – 1987
    Pegram Award, Columbia University, 1984
    National Cancer Institute, 1980-82
    Public Health National Research Service Award, 1980 – 1981
    Member, American Chemical Society, 1979
  • Areas of Interest Mechanism of action of non-heme iron metalloproteins with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions.
  • Research Areas The Caradonna research group is interested in understanding the mechanism of action of non-heme iron metalloproteins, with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions. Our efforts span the continuum from the investigation of small molecule synthetic complexes that catalyze oxygen atom transfer reactions, to the characterization of an interesting class of iron/pterin-dependent aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylases), to the computational design of functional metalloproteins (iron-sulfur-based electron transfer clusters, Fe and Mn superoxide dismutanse). A broad-based approach, including chemical, molecular biological, and biophysical (spectroscopic) techniques, is used to develop a global understanding of the intrinsic characteristics of the active site metal centers and the role played by the protein matrix in regulating, modulating, and tuning these properties.

Biography

Publications

Affiliation: Affiliated Faculty (MSE), Primary & Affiliated Faculty (MSE)