Dan Ehrlich, Ph.D.

Daniel Ehrlich

Research Professor, Biomedical Engineering

Research Professor, Biomedical Engineering

  • Primary Appointment Research Professor, Biomedical Engineering
  • Education Ph.D., Optics, University of Rochester
  • Areas of Interest New instrumentation and methods for cell-based assays, deep-UV microscopy, microfluidics for assay of DNA, RNA and protein.
  • Research Areas The emerging view is that cancer shares an analogy to contagious disease. Under healthy systemic control, or with the intervention of drugs, an evolving balance is developed between healthy and potentially malignant rare progenitor cell types. Therefore, “base-line” genomic data is insufficient, and averaged genomic data or averaged expression patterns are very indirect and blunt as a diagnostic.

    Our laboratory is developing the new methods and instruments needed to gather sufficiently detailed molecular snapshots from sufficiently specific rare-cell phenotypes for both drug development and clinical diagnosis. To some large part, the technology that can fill the gap can be assembled from high-speed microscopy and microfluidics, however, the instruments and work flow need to be redesigned, and other elements such as efficient cost-effective quantitative expression analysis need to be re-thought in format.

Publications

Affiliation: Research Faculty (BME)