Densmore’s Contributions Part of a $32 Million DARPA Contract to Cutting Edge Synthetic Biology Effort
By Rebecca Jahnke (COM ’17)
A $32 million contract from the Defense Advanced Research Projects Agency (DARPA) was awarded to “The Foundry”, a DNA design and manufacturing facility at the Broad Institute of MIT to support the engineering of novel biological systems. Boston University Computer Engineering Professor Douglas Densmore’s role in automating the facility’s design process with software inspired by electrical and computer engineering was key in establishing novel, large scale, parallel design processes that landed the contract.
The Foundry focuses on designing, testing and fabricating large sequences of genetic information. The intent is to create DNA nucleotide arrangements that can be applied widely for medical, industrial and agricultural purposes.
Engineers at the Foundry work with chains containing millions of nucleotides, all of which are specified using only the letters A, T, G and C. The Foundry sought Densmore’s computer aided design expertise to help automate complex processes because the feat is impossible for an engineer writing out such vast sequences by hand.
Densmore’s contributions will allow the Foundry to significantly increase its output of DNA designs beyond what would have been possible relying on conventional design techniques. The Foundry’s work will lead to greater advances faster – tackling issues like delivering nitrogenous fertilizer to cereal crops and converting compounds that naturally occur in human bacteria into therapeutic drugs.
Douglas Densmore is a Kern Faculty Fellow, Hariri Institute for Computing and Computational Science and Engineering Junior Faculty Fellow, and Professor in the Department of Electrical and Computer Engineering at Boston University. He also acts as the director of the Cross-disciplinary Integration of Design Automation Research (CIDAR) group at Boston University, where his team develops computational and experimental tools for synthetic biology. His research facilities include both a computational workspace in the Department of Electrical and Computer Engineering as well as experimental laboratory space in the Boston University Biological Design Center. Densmore is the President of the Bio-Design Automation Consortium, Nona Research Foundation, and Lattice Automation, Inc.
For more information, please see the Broad Institute of MIT press release.