Joint Research Focused on Medical Imaging and Image-Guided Interventions
By Mark Dwortzan
Boston University College of Engineering Assistant Professor Darren Roblyer (BME) and Brigham & Women’s Hospital radiologist Srinivisan Mukundan are exploring a strategy that combines a new optical imaging device developed by Roblyer with emerging magnetic resonance imaging (MRI) techniques to probe malignant brain tumors during chemotherapy treatment. Their research could enable clinicians to monitor the effectiveness of chemotherapy over the course of treatment and implement changes to chemotherapy drugs and dose levels as needed.
The project is one of five now receiving funding through an ongoing partnership between Boston University and Brigham & Women’s Hospital. On September 12 at the BU Photonics Center, Dean Kenneth R. Lutchen and Dr. Steven Seltzer, Chair of the BWH Department of Radiology, announced the second year of the partnership, which has already provided one year of seed funding to projects ranging from image-guided cancer drug delivery to early detection of heart disease.
“The goal is to leverage synergies between Brigham & Women’s Hospital’s Radiology Department in imaging and image-guided interventions with the College of Engineering’s strengths in developing new materials and technologies as well as novel techniques for processing images and large data sets,” said Associate Professor Tyrone Porter (ME, BME, MSE), who is coordinating the partnership. “The hope is to stimulate research collaborations between the two campuses and develop a National Institutes of Health training program in clinical imaging and image-guided interventions.”
The brainchild of Lutchen and Seltzer, the BU-BWH partnership brings together world-class expertise and equipment from Boston University entities such as the BU Photonics Center and the BU Center for Nanoscience & Nanobiotechnology, and from the BWH Department of Radiology, home to the National Institutes of Health’s National Center for Image-Guided Therapy and the Advanced Multimodality Image Guided Operating Suite (AMIGO). Joint research between the two campuses could result in less invasive, more accurate medical imaging and image-guided interventions.
“There’s no question that in so many dimensions, imaging is at the foundation of a tremendous amount of potential breakthroughs in medical discoveries and practice, but there are huge challenges from a scientific and technical point of view,” said Lutchen. “We’ve got tons of interested students and faculty here that need and want to use imaging technologies to address interesting and important questions.”
First-round projects include the engineering of a new “molecular imaging” MRI contrast agent for detecting early calcification of the aortic valve; the combination of ultrasound and MR data to evaluate the elastic properties of tissues, which are associated with pathological indicators of disease; a clinical decision support system for patient-specific cancer diagnosis and management; and ultrasound-guided delivery of chemotherapy drug-laden nanoparticles to metastasized lung cancer cells in the brain. Applications for second-round projects are now underway.
All projects involve at least one principal investigator from each of the partnering institutions, who jointly advise a doctoral student on a project that could positively impact clinical practice. Participating ENG faculty include Professors Joyce Wong (BME, MSE), Paul Barbone (ME, MSE), Venkatesh Saligrama (ECE, SE) and Yannis Paschalidis (ECE, SE); Associate Professor Porter; and Assistant Professor Roblyer.
“The fields of biomedical imaging and bioengineering have been converging and collaborating for decades, and that collaboration continues to get closer and closer,” said Seltzer, noting a burgeoning clinical need for advanced technologies in functional and molecular imaging; information technologies ranging from data mining to image processing; and minimally-invasive diagnostic and therapeutic procedures guided by high-technology imaging techniques.