Laboratory Safety Center Program
1. Purpose and Scope
The Laboratory Safety Center is designed to create uniformed access, increase awareness and promote communication of safety-related documents within Boston University and Boston Medical Center research laboratories. These documents encompass federal, state, and municipal regulations, Boston University policies, and standard operating procedures for laboratories. The Laboratory Safety Center provides these documents as well as safety related equipment in a visibly accessible fashion that is recognized by the laboratory staff, other personnel with access to the laboratory, visitors, and the Office of Environmental Health and Safety.
1910. 1450 OSHA Occupational Exposure to hazardous chemicals in laboratories
1910.1200 OSHA Hazard Communication
1910.1030 OSHA Blood Borne Pathogen
1910.101 OSHA Hazardous Materials
2.2. BU Policies
2.3. Other SOP
Research Safety Quarterly Inspection Program
High Hazard Chemical
2.4. Supplementary Documents
Biosafety in Microbiological and Biomedical Laboratories (5th Edition)
Guidelines for the use of Recombinant DNA Molecules
Laboratory Safety Center — A area designated in the laboratory, accessible to all laboratory staff, where documents and other materials can be stored. The Laboratory Safety Center services as proactive approach towards the organization of safety and compliance related documents, policies, and lab specific procedures provided for laboratory personnel access.
Laboratory Safety Logbook — A binder provided to the laboratory by Environmental Health and Safety (EHS) and kept in the Laboratory Safety Center. The Laboratory Safety Logbook provides a centralized location for the principal investigator and laboratory staff to keep laboratory-related records and other documents pertaining to the safe and compliant operation of the specific laboratory. Separate logbooks will be provided for chemical safety, biological safety, and radiation safety.
Principal Investigator (PI) — A faculty or person in an equivalent position, in charge of a laboratory and with overall responsibility to ensure the safety of the laboratory facility and its personnel.
Laboratory Safety Coordinator (LSC) — A person with knowledge of the laboratory hazards, procedures, and staff, appointed by the PI to supervise and be in charge of the daily laboratory operations and to ensure safety and compliance within the laboratory.
Research Safety Specialist (RSS) — An Environmental Health and Safety representative with working knowledge of the laboratories assigned to him or her. This individual will be responsible for providing documents necessary from EHS, as well as completing inspections of the laboratory.
Laboratory Safety Kit — An assortment of laboratory-related spill equipment, a first aid kit, and other equipment provided to the laboratories by EHS and maintained by the PI or LSC with assistance from EHS.
4. Roles & Responsibilities
Environmental Health and Safety (EHS) will provide the laboratory with the necessary documentation needed for the laboratory and assist the laboratory in identifying a suitable location within the laboratory for the Laboratory Safety Center. EHS will also work in accordance with the laboratory personnel to identify and develop necessary laboratory-specific standard operating procedures to be included in the LSC. EHS will review the Laboratory Safety Center quarterly as part of the Laboratory Safety Inspection Program and update as necessary.
Principal Investigator shall designate a practical, visible area of the laboratory as the Laboratory Safety Center and keep safety and compliance documents in this area. The PI will ensure that the Laboratory Safety Center is current and up to date, either personally or by a designated Laboratory Safety Coordinator. The PI will also ensure that all laboratory staff are aware of the location of the Laboratory Safety Center and are familiar with its contents.
Lab Safety Coordinator as directed by the PI, serve as a direct liaison for EHS. The Lab Safety Coordinator will assist the PI in keeping the Laboratory Safety Center current and up-to-date, and will, with assistance from EHS, provide appropriate standard operating procedures, records, and other laboratory-specific information.
5. Special Requirements
5.1. Equipment and Supplies Required
Shelf space within the laboratory, easily accessible by all laboratory staff, without visual or physical obstruction, and in an area of minimal potential hazards
New laboratory personnel shall be made aware of Laboratory Safety Center’s location and become familiar with its contents before beginning work.
EHS’s Laboratory Safety Training for Researchers will refer to the Laboratory Safety Center whenever plans, manuals, or other documents kept there are discussed.
5.3. Monitoring Requirements
EHS will review the contents of the Laboratory Safety Center for accuracy and accessibility quarterly as part of the Quarterly Laboratory Safety Inspection Program. The PI or LSC should monitor the contents and updating the information on a regular basis to ensure the most current accuracy.
6. Applicable Locations
Each Principal Investigator at Boston University and Boston Medical Center must have a location easily accessible to all laboratory staff for the Laboratory Safety Center. The location will be provide enough space to hold the binders provided as well as the laboratory spill kit.
7. Procedures and Instructions
Location — EHS and the PI or SC will identify a location within the laboratory that is suitable for the Laboratory Safety Center. This location will be identified with a sign, provided by EHS, that reads “Laboratory Safety Center”. This area should remain easily accessible by all laboratory staff, without visual or physical obstruction, and in an area of minimal potential hazards. The Research Safety Specialist will ensure this area remains in
specified conditions through out regular inspections.
Laboratory Safety Logbook — The Laboratory Safety Logbook(s) will be kept in the Laboratory Safety Center. The Logbook(s) will hold the information specific to the laboratory. At the beginning of each quarterly inspection, The PI or LSC meet with the research safety specialist assigned to their laboratory. The research safety specialist will ensure that the Laboratory Safety Center is maintained to completion, all documentation and any safety equipment should be visible and stocked. The Research Safety Specialist will provide any new information to the laboratory safety logbooks, including current inspection reports, follow ups to inspection reports or copies of up coming inspection reports for a self evaluation.
The Laboratory Safety Logbooks for the lab will be reviewed for any changes, updates and to ensure laboratory compliance of the required documentation. The Chemical Safety and Biological Safety Logbooks should be evaluated for the following:
|Tab||Responsible Party||Chemical Safety Log Book||Bio Safety Log Book|
|1||PI, LSC||Chemical Inventory: The PI or LSC. should be updating the inventory regularly on the Research Information Management System (RIMS). It is
recommended that this is updated and printed and placed in the inventory section of the binder.
|IBC application/Biological Use Authorization: This tab should have the copy of the PI specific IBC application, approval letters, protocol specific safety addendums, modification requests, and approvals.|
|2||PI, LSC||Personnel and User Certification and Training: Kept as an up to date roster of individuals who work with chemicals in the laboratory This tab should also have the dates of the most recent training records of the lab personnel. This should be kept up to date.||Personnel and User Certification and Training: The IBC provides a User Certification Form listing the names of approved individuals for each IBC approved protocol. Copies of all modifications for deleting and adding personnel should also be kept under this tab. These should be organized under the Protocol.|
|3||PI, LSC, RSS||Lab Safety Committee Communications: Use this tab to file any communication with or from the Lab Safety Committee.||IBC communications: Use this tab to file any communications with, or from the IBC|
|4||PI, LSC, RSS||Inspection Report: Place a hard copy of all inspection reports and audits conducted by Research Safety and responses to findings under this tab. If the PI or LSC conducts a self evaluation of the lab this should also be placed under this tab.||Inspection Report: Place a hard copy of all inspection reports and audits conducted by Research Safety and responses to findings under this tab. If the PI or LSC conducts a self evaluation of the lab this should also be placed under this tab.|
|5||PI, LSC||Lab Safety Committee Policies: Policies can be found on the EHS web site. Any special notice issued by the LSC should be placed in tab. This tab should also be used by the PI to place any lab specific policies that impact the laboratory staff.||IBC Policies: Policies can be found on the IBC web site. Any special notice issued by the IBC should be placed in tab. This tab should also be used by the PI to place any lab specific policies that impact the laboratory staff.|
|6||RSS||EHS Communications: Periodically issued newsletters, safety updates or other informational pamphlets. These should be kept in the binder as well.|
|7||PI, LSC, RSS||Chemical Specific Information: EHS has prepared and pre-populated the high hazard chemicals MSDS information that is currently in the laboratory chemical inventory. Any new high hazard chemicals MSDS should be kept up to date and under this tab.||Agent Specific Information: The IBC has prepared informational sheets for a select group of biological agents that have high potential for human
disease. Information includes disease caused by the agent, symptoms of the disease and actions to be taken in the event symptoms occur. The IBC will provide the information.
|8||PI, LSC, RSS||Waste Records: The requirements for waste determination are pre-populated by EHS. The PI/LSC should populate this area with current waste disposal requests.||Autoclave QC test: All records for autoclaves used for rendering waste as noninfectious be subject to annual calibration, routine QC testing and daily record keeping. (Per. Mass. Management of Medical or Biological Waste Regulation.) Place lab specific autoclave SOP here.|
|9||PI, LSC, RSS||Incident Reports: Copies of all incident reports and corrective actions should be filed under this tab. All minor incidents that do not require reporting should be documented by the PI or SC ( a sample has been included)||Biosafety Cabinet Certifications: All biosafety cabinets are required to be re-certified annually. Place records under this tab.|
|10||PI, LSC, RSS||Shipping: Copies of shipping papers for materials sent to colleagues or received from others should be placed under this tab||Biological Waste Disposal: A copy of the Lab Waste Disposal Chart has been placed by the EHS staff in this area. Copies of campus specific waste management guidelines should also be placed in this section.|
|11||PI, LSC, RSS||Misc. place all miscellaneous records, correspondence or lab relevant materials in this section||Incidents Report: Copies of all incident reports and corrective actions should be filed under this tab. All minor incidents that do not require reporting should be documented by the PI. Or LSC( a sample has been included)|
|12||PI, LSC, RSS||Fume Hood Records: Copies of annual fume hood inspections and maintenance should be kept under this tab.||Shipping: Copies of shipping papers for materials sent to colleagues or received from others should be placed under this tab|
|13||PI, LSC||Laboratory Specific Records: This section should contain any documents such as any SOP, equipment maintenance or QC records||Misc. place all miscellaneous records, correspondence or lab relevant materials in this section|
|14||PI, LSC||Laboratory Specific Records: This section should contain any documents such as any SOP, equipment maintenance or QC records|
All changes to any of the above tabs should be noted and followed up on with inspection reports.
At this time the Laboratory Spill kit should also be inspected:
Contents of the spill kit should include:
- Spray bottle 32oz. (use for cleaning of biological spills) to be mixed at a 10% bleach solution.
- 2x hazmat pillows 8”x8” capable of holding up to 30oz per pillow (# PIL302)
- 1x hazmat sock 3” x 46” capable of holding up to 100oz (#124CR)
- 2.5 spill pads 20”x15” capable of holding 30 oz per pad (#mat203)
- 1x first aid kit used for first response treatment (Top safety Products)
All pads, socks and pillows can be ordered on New Pig.
9. Records Management
10. Program Revision History
|Version||Section / Paragraph Changed||Changes Made||Effective Date|
|V.1||N/A||None, Original Version||3/30/10|
|V.1.1||All||Changed from SOP format to program format||11/12/10|