ECE Distinguished Lecture with Christopher Hollot

4:00 pm on Wednesday, March 5, 2014
Photonics Center, 8 Saint Mary’s St., Room 211
Regulation of Cell Populations in Individuals Using Feedback-Based Drug-Dosing Protocols

With C. V. Hollot,
Department Head,
University of Massachusetts, Amherst

Faculty Host: Christos Cassandras

Refreshments will be served outside Room 339 at 3:45 p.m.

Abstract: This talk is concerned with the regulation of cell populations in individuals using feedback-based drug-dosing protocols. Cell populations can be affected by drugs that induce formation of cell-types as well as by inherent cell lifespans. Cell populations can be modeled by compartmental models involving cell lifespan distributions, and these distributions vary across individuals. A challenge arises in designing a single feedback-based drug-dosing protocol to regulate cell populations that is robust to this cell lifespan uncertainty. A motivating application is the use of artificial erythropoietin (EPO) as a drug to regulate red blood cells and anemia in individuals with chronic kidney disease.

About the Speaker: C. V. Hollot received his Ph.D. in electrical engineering from the University of Rochester in 1984. He joined the ECE Department at the University of Massachusetts, Amherst, receiving the NSF PYI in 1988 and becoming an IEEE Fellow in 2004. He has been Department Head since 2006. His research interests are in the theory and application of feedback control.