Center for Neuroscience Systems Seminar with Hung Cao

12:00 pm on Thursday, April 12, 2012
1:00 pm on Thursday, April 12, 2012
2 Cummington Street, Room 109
Boston University Center for Neuroscience Systems Neuroscience Group Seminar

Implantable Micro Electrode Arrays and Wireless Approaches for Neuroscience and Biomedical Applications

Hung Cao, PhD

Electrical Engineering Department
The University of Texas at Arlington

Implantable neural probes have been used for sensing and stimulating the neurons in various neuroscience studies. Electrochemistry approaches using micro electrode arrays (MEAs) for
sensing neurotransmitters were desirable recently due to their versatility, specificity and real-time
operation. However, a biocompatible and integrated device with integrated reference electrode has not been implemented. Beside, optogenetic stimulation is emerging nowadays owing to its selectivity, high throughput and potential for non-invasive approaches. In his work, Dr. Cao has developed various types of neural probes to address existing issues. Several nanostructure surface modification methods were used to enhance the performance of electrochemical neurotransmitters sensors. Integrated micro reference electrodes were fabricated monolithically in the same device, which makes a compact and robust system. A specially-configured probe was made containing a micro-LED for optogenetic stimulation and electrodes for electrophysiology recording. Animal models were established to test those devices in vivo to show the proof of principle. Dr. Cao has also proposed and implemented a batteryless and wireless platform which could be used for various medical implants. The system consists of a wearable unit and an implant. The energy transfer was done by magnetic coupling. Gastroesophageal reflux disease (GERD) and urinary incontinence (UI) were targeted. An ultimate goal of a wireless sensing and stimulating system for neuroscience studies is proposed.

Light lunch will be available.