Philip C. Trackman
Director, Graduate Programs in the Department of Molecular & Cell Biology, Professor, Department of Molecular & Cell Biology
700 Albany Street
Boston, MA 02118 USA
PhD, Boston University
Postdoctoral Fellow, Brandeis University
Research is focused on the regulation and molecular mechanisms of extracellular matrix accumulation in mineralized and non-mineralized normal tissues, and on abnormalities that occur in these pathways in oral and systemic pathologies. The roles of extracellular biosynthetic enzymes including lysyl oxidase, and proteolytic processing enzymes such as procollagen N- and C-proteinases are of particular interest. Thus, we analyze the in vitro and in vivo regulation of these enzymes, of other extracellular matrix components, and of selected cytokines under normal and pathologic conditions. These studies have relevance to elucidation of molecular events and mechanisms that occur in normal bone formation, altered bone metabolism in diabetes, drug-induced gingival hyperplasia, and other neoplastic disorders.
Min C, Kirsch KH, Zhao Y, Jeay S, Palamakumbura AH, Trackman PC, Sonenshein GE. The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer. Cancer Res. 2007 Feb 1;67(3):1105-12
Kantarci A, Black SA, Xydas CE, Murawel P, Uchida Y, Yucekal-Tuncer B, Atilla G, Emingil G, Uzel MI, Lee A, Firatli E, Sheff M, Hasturk H, Van Dyke TE, Trackman PC. Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis. J Pathol. 2006 Sep; 210(1):59-66.
Heng ED, Huang Y, Black SA, Trackman PC. CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins.J Cell Biochem. 2006 May 15;98(2):409-20.
Palamakumbura AH, Trackman PC. A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. Anal Biochem. 2002 Jan 15;300(2):245-51.
Uzel MI, Kantarci A, Hong H-H, Uygur C, Sheff MC, Firatli E, Trackman PC. Connective tissue growth factor in drug-induced gingival overgrowth. J. Periodontol. 2001.
Hong H-H, Uzel MI, Duan C, Sheff MC, and Trackman PC. Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-b1 and detection in human gingiva. Laboratory Investigation 79:1655-1667, 1999.
Feres-Filho EJ, Choi YJ, Han X, Takala TES, and Trackman PC. Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-b1 in osteoblastic MC3T3-E1 cells. J. Biol. Chem. 270:30797-30803, 1995.
|Publication Number:||WO/2005/094424||International Application No.:||PCT/US2005/000631|
|Publication Date:||13.10.2005||International Filing Date:||06.01.2005|
Growth Factors and Gingival Fibrosis, 8//2007-6/2012 NIH-R01
Inhibited Intramembranous Bone Healing in Diabetes, 6/2003-5/2008 NIH-R01
Lysyl Oxidase Inhibition of RAS-Mediated Transformation, 4/2004-3/2009, NIH-R01 Co-PI
Immunohistochemistry of hyperplastic human gingival tissues from a patient undergoing treatment with Dilation (AtoH), and tissue from a patient undergoing therapy with nifedipine (I and J). Sections stained with TGF-b1 antibody are shown in A, B, and I. A and B are photos of the same section, but different magnifications. The section shown in C is stained with nonimmune IgG and is a serial section of that shown in A and B. Sections stained with CTGF antibody are shown in D, E, and J, D and E show different magnifications of the same section. The section shown in F is stained with preimmune IgG and is a serial section of that shown in D and E. The section stained with lysyl oxidase antibody is shown in G, and the serial section (H) is stained with nonimmune IgG. Hong, et al. 79 1655-1666, 1999.