Barbara Nikolajczyk

Associate Professor of Microbiology, Associate Professor of Molecular & Cell Biology

  • Title Associate Professor of Microbiology,
    Associate Professor of Molecular & Cell Biology
  • Office 72 East Concord Street
    Boston, MA 02118-2394 USA
  • Phone 617-638-7019
  • Education B.S. The Ohio State University, Columbus, Ohio
    Ph.D. The University of North Carolina at Chapel Hill

The Nikolajczyk lab reports the first comprehensive T cell phenotyping in samples from type 2 diabetes patients in the Journal of Immunology (Jagannathan-Bogdan et al., 2011; Vol. 186 pp. 1162-1172). This work goes beyond studies in mouse models of the disease by showing that continuous interaction between T cell and monocytes is required to maintain pro-inflammatory T cell skewing in patients. These results are clinically important because they introduce the idea that immunotherapy may have applicability in treating human type 2 diabetes.

Representative Publications

  1. McDevit, D.C., and B.S. Nikolajczyk. 2006. Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation. Mol Immunol. 43(10):1541-1548. PMID: 16313959
  2. Liang, M.D., Y. Zhang, D. McDevit, S. Marecki, and B.S. Nikolajczyk. 2006. The Interleukin-1beta Gene is Transcribed from a Poised Promoter Architecture in Monocytes. J. Biol. Chem. 281:9227-9237. PMID: 16439360
  3. Nikolajczyk, B. 2006. Regulation of Cytokine Transcription in the Context of Chromatin. Arch. Immunol. 54:299-305.
  4. Nikolajczyk, B.S., S.H. Sardi, J.R. Tumang, and L.M. Ganley-Leal. 2007. Immunoglobulin Kappa Enhancers are Differentially Regulated at the Level of Chromatin Structure. Mol. Immunol. Mar 21; [Epub ahead of print]. PMID: 17382392
  5. Zhang, Y., S. Saccani, H. Shin, and B.S. Nikolajczyk. 2008. Dynamic protein associations define two phases of IL-1beta transcriptional activation. J. Immunol. 181:503-512. PMID: 18566416
  6. *Shin, H., Y. *Zhang, M. Jagannathan, H. Hasturk, A. Kantarci, H. Liu, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2009. B cells from periodontal disease patients express surface Toll-like Receptor 4. J. Leuk. Biol. 85:648-655.  *equal contribution. PMID: 19118102
  7. Noronha, A.M., Y. Liang, J.T. Hetzel, H. Hasturk, A. Kantarci, A Stucchi, Y. Zhang, B.S. Nikolajczyk, F.A. Farraye, and L.M. Ganley-Leal. 2009. Hyperactivated B cells in human inflammatory bowel disease. J. Leuk. Biol. 86:1007-1016. PMID19589946
  8. Jagannathan, M., H. Hasturk, Y. Liang, H. Shin, J.T. Hetzel, A. Kantarci, D. Rubin, M.E. McDonnell, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2009. TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients. J. Immunol. 183:7461-7470. PMID: 19917698
  9. Jagannathan, M., M.E. McDonnell, Y. Liang, H. Hasturk, J.T. Hetzel, D. Rubin, A. Kantarci, T.E. Van Dyke, L.M. Ganley-Leal, and B.S. Nikolajczyk. 2010. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia 53:1461-1471. PMID: 20383694
  10. Nikolajczyk, B.S. 2010. B cells as unappreciated mediators of human non-autoimmune inflammatory disease.Cytokine 50:234-242. PMID: 20382544
  11. Ganley-Leal, LM, Liang, YM, Jagannathan-Bogdan, M, Farraye, FA and Nikolajczyk, BS. 2010. Differential regulation of TLR4 expression in human B cells and monocytes. Mol. Immunol. 48:82-88. PMID: 20956019
  12. Jagannathan-Bogdan, M, McDonnell, ME, Shin, H, Rehman, Q, Hasturk, H, Apovian, CM, and Nikolajczyk, BS. 2011. Elevated pro-inflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in T2D. J. Immunol. 186:1162-172. PMID: 21169542
  13. Nikolajczyk, BS, Jagannathan-Bogdan, M, Denis, G. 2012. The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point. Immunol. Rev. 249:253-275. PMID 22889227.
  14. Belkina, AC, Nikolajczyk, BS, Denis, GV. 2013. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J. Immunol. [Epub ahead of print]. PMID: 23420887.
  15. DeFuria, J, Belkina, AC, Jagannathan-Bogdan, M, Snyder-Cappione, J, Carr, JD, Nersesova, Y, Markham, D, Strissel, KJ, Watkins, A, Allen, J, Bouchard, J, Torald, G, Jasuja, R, Obin, MS, McDonnell, ME, Apovian, C, Denis, GV and Nikolajczyk, BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile. Proc. Natl. Acad. Sci. USA 110:5133-5138, 2013. PMID: 23479618.
Molecular & Cell Biology

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