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Monday, April 28, 2014, 7:30am – 6pm

This symposium will bring basic scientists and clinicians together to discuss the latest developments in Head & Neck Cancer research and therapy. The intention of this meeting is to promote interactions between clinicians and researchers from diverse disciplines and to work towards bridging the translational gap.

The keynote addresses will be given by Dr. Jatin P Shah, Chief of the Head and Neck Program at Memorial Sloan Kettering Cancer Center, and Dr. Robert A. Weinberg, Founding Member of the Whitehead Institute for Biomedical Research and Professor of Biology at the Massachusetts Institute of Technology. The agenda also includes a poster session and four panel discussions on Early Detection and Progenitors, Biomarkers/Genomics, Epidemiology and HPV Disease, and Cancer Treatment and Recurrence.

Target audience

•           Otolaryngology / Head and Neck Surgery
•           Medical Oncology
•           Radiation Oncology
•           Surgical Oncology
•           Oral and Maxillofacial Surgery
•           Oral and Maxillofacial Radiology
•           Oral and Maxillofacial Pathology
•           Dental Public Health
•           Head & Neck Cancer Researchers

Learning objectives

Upon completion of this activity, participants will be able to:

1. Describe current research on the etiology, pathogenesis,
metastasis and treatment of  head and neck cancer;

2. Apply innovative therapeutic approaches to the treatment
of head and neck cancer patients;

3. Identify the translational gap whereby advances in research
are not translated into clinical applications that directly
benefit patient health.

Course Director

Dr. Andrew Salama
Assistant Professor, Department of Oral & Maxillofacial Surgery and Director
Advanced Specialty Education Program in Oral & Maxillofacial Surgery

To request reasonable accommodations for a disability please notify GSDMR@bu.edu
in writing, at least two weeks prior to the conference.

Please register Online.

Click here for information on how to submit abstracts.

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Boston University School of Medicine, Boston University School of Dental Medicine and the Dana-Farber Cancer Institute.  Boston University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Boston University School of Medicine designates this live activity for a maximum of 7.50 AMA PRA Category 1 Credits ™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The Symposium is sponsored by Boston University School of Medicine.

The meeting is provided in collaboration with the Boston University Henry M. Goldman School of Dental Medicine and the Dana-Farber Cancer Institute.

Agenda

7:30 – 8 a.m. Registration/Exhibits
8 – 8:10 a.m. Welcome & Opening RemarksJeffrey HutterDean and Spencer N. Frankl Professor in Dental Medicine

 

Maria Kukuruzinska

Professor, Department of Molecular & Cell Biology
Associate Dean for Research

hutter-jeffrey_100 DrMariaKukuruzinska

Session 1 – Early Detection and Progenitors:
8:10 – 8:30 a.m. Oral Epithelial Dysplasia; a surgeon’s perspectiveAndrew Salama, DDS, MDAssistant Professor, Oral and Maxillofacial Surgery

Otolaryngology Head and Neck Surgery

Residency Program Director (OMFS)

Henry M. Goldman School of Dental Medicine

Salama
8:30 – 8:50 a.m. Application of non-linear intravital microscopy to image head and neck cancerRoberto Weigert, PhDChief, Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health Weigert
8:50 – 9:10 a.m. Epigenetic Control of HNSCC Invasive GrowthCun-Yu Wang, DDS, PhDAssociate Dean and No-Hee Park Endowed Professor
UCLA Dentistry
Cun-Yu-Wang
9:10 – 9:30 a.m. DNA methylation based screening and surveillance of head and neck cancer
Joseph Califano, MDProfessor of Otolaryngology – Head and Neck Surgery

Johns Hopkins Medical Institutions

Califano-Joseph
9:30 – 9:50 a.m. Discussion
Keynote Address:
9:50 – 10:20 a.m. Cancer stem cells and the epithelial-mesenchymal transition in carcinomasRobert A. Weinberg, PhDMember of the Whitehead Institute, Director of the Ludwig/MIT Center for Molecular Oncology, and Professor, Department of Biology, MIT Weinberg
10:20 – 10:40 a.m. Coffee Break / Poster Session / Exhibits
Session 2 – Biomarkers / Genomics / Personalized Medicine:
10:40 – 11 a.m. Challenges in Oral Cancer Precision MedicineJennifer R. Grandis, MD, FACSVice Chair for Research, UPMC

Endowed Chair in Head and Neck Cancer Surgical Research, Department of Otolaryngology

Assistant Vice Chancellor for Research Program Integration in the Health Sciences

Distinguished Professor of Otolaryngology & Pharmacology

University of Pittsburgh School of Medicine

Program Leader, Head & Neck Cancer Program

University of Pittsburgh Cancer Institute

American Cancer Society Clinical Research Professor

Grandis-Jennifer
11 – 11:20 a.m. Genomics of HPV Driven Head and Neck CancersPeter Hammerman, MD, PhDAssistant Professor Harvard Medical School

Department of Medical Oncology, Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute

Associate Member Broad Institute of Harvard and MIT

Hammerman
11:20 – 11:40 p.m. Targeting genetic lesions in head and neck cancersStephen Michael Rothenberg, MD, PhDInstructor

Massachusetts General Hospital Cancer Center

rothenberg
11:40 – 12 p.m. Discussion
Keynote Address:
12 – 12:30 p.m.

The Changing role of the Surgeon in Multidisciplinary Treatment of Cancers of the Head and Neck

Jatin P. Shah, MD, PhD (Hon), FACS, FRCS(Hon), FRACS(Hon), FDSRCS(Hon)

E W Strong Chair in Head and Neck Oncology

Chief, Head and Neck Program, Memorial Sloan Kettering Cancer Center

Professor of Surgery, Weill Medical College of Cornell University

Shah
12:30 – 1:30 p.m.

Lunch / Exhibits

Session 3 – Epidemiology and HPV Disease:
1:30 – 1:50 p.m. HPV related oropharynx cancer : a new entity in search of a new therapyRobert Haddad, MDDisease Center Leader, Head and Neck Oncology Program, Dana-Farber Cancer Institute Haddad
1:50 – 2:10 p.m. Carcinogenic Activities of Human PapillomavirusesKarl Munger, PhDProfessor of Medicine, Harvard Medical School Munger
2:10 – 2:30 p.m. The epidemiology of HPV in head and neck cancerKarl Kelsey, MDProfessor of Epidemiology and Laboratory Medicine and Pathology

Brown University

2:30 – 2:50 p.m. Changing epidemiology of Head and Neck Cancer:  Effects of the HPV epidemicThomas Carey, PhDProfessor of Pharmacology and Otolaryngology/Head and Neck Surgery

Associate Chair for Research in the Department of Otolaryngology/Head and Neck Surgery at the University of Michigan School of Medicine 

Co-Director of the Head and Neck Oncology Program of the University of Michigan Comprehensive Cancer Center

Carey
2:50 – 3:10 p.m. Discussion
3:10 – 3:30 p.m. Coffee Break / Poster Session / Exhibits
Session 4 – Cancer Treatment and Recurrence:
3:30 – 3:50 p.m. Field cancerization and SCC development: Notch/CSL signaling as primary determinantGian Paulo Dotto, MD, PhDProfessor of Biochemistry, University of Lausanne, Switzerland

Biologist, Mass Gen Hosp, Charlestown, MA

Dotto
3:50 – 4:10 p.m. Genomics and Therapy of Head and Neck CancerCarter Van Waes, MDChief, Head and Neck Surgery Branch

Clinical Director, NIDCD

National Institutes of Health

Van-Waes
4:10 – 4:30 p.m. Targeted Therapy for Recurrent/Metastatic Head and Neck CancerNicole Chau, MDMedical Oncologist, Center for Head & Neck Oncology, Dana-Farber Cancer InstituteInstructor in Medicine, Harvard Medical School Chau
4:30 – 4:50 p.m. Surgery as a tool for deintensification of treatment for oropharyngeal cancersScharukh Jalisi, MDDirector, Division of Head and Neck Surgery and Skullbase Surgery, Boston Medical Center

Assistant Professor, Department of Otolaryngology-Head and Neck Surgery and Department of Neurology, Boston University School of Medicine

Jalisi
4:50 – 5:10 pm Discussion
5:10 – 5:20 pm Closing Remarks
5:30 pm Reception / Exhibits