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GSDM Resident Awarded AAE Grant

January 8, 2013

AAE Grant-200-bGSDM resident Dr. Haytham Sabri Jaha was recently awarded a $13,010 grant by the American Association of Endodontists (AAE) foundation to support his research project, “The effect of DSP fragment on dental pulp stem cells.”

Dr. Sami Chogle, Director of the Advanced Specialty Education Program in Endodontics, applauded Dr. Jaha’s achievement. “We are proud of the hard work and commitment our residents have put into their research projects, which have resulted in the AAE foundation supporting their research,” said Dr. Chogle. “Congratulations to the most recent recipient, Dr. Jaha, for his research on stem cells.”

Dr. Jaha is a third-year student in the combined program of Doctor of Science (DSc) in Oral Biology and CAGS in Endodontics. He’s working on this project under the supervision of Associate Professor Dr. Yuki Mochida.

“It’s an honor for an endodontic resident to get such support from the AAE,” said Dr. Jaha. “It will help tremendously in my research.”

Drs. Jaha and Mochida are studying a particular disease called Dentinogenesis imperfecta (DGI), which is one of the most common clinical and genetic disturbances of dentin formation. DGI causes several dentin defects including opalescent color ranging from gray to brownish blue, bulbous-shaped crowns, disorganized distribution pattern and few dentinal tubules, nodular dentin appearance, easy chipped away enamel pulp exposure and pulp space obliteration.

In their preliminary studies they found DSP—a fragment of DSPP—has a unique ability to generate type I collagen, a major composition of dentin.

The data from this study should provide new insights into the pathophysiological function of DSPP protein in dentin-pulp formation and into potential regenerative root canal therapies. It may generate a new concept in managing an exposed or  perforated pulp space by  controlling the activity of pulp cell activity (stimulating the tissue in pulpodentin complex) by this biological molecule to generate a reparative dentin in the affected area (pulp capping technique).

“Congratulations to Dr. Jaha for receiving this AAE grant,” said Dean Jeffrey W. Hutter. “His project exemplifies the innovative research we foster and encourage at the Henry M. Goldman School of Dental Medicine.”

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