Pre-doctoral Research

DMD 16 Group EDIT

For information regarding eligibility criteria, access to Blackboard courses, and general Pre-doctoral inquiries, please contact Afaf Hourani, Assistant Director of Pre-doctoral Research.

Pre-doctoral Research at GSDM

Pre-doctoral Research Curriculum

Research Faculty Mentors


Pre-doctoral News and Announcements:

For information on upcoming conferences and meetings, please go to http://www.bu.edu/dental-research/events-workshops/conferences/


Scholars Day 2014 will take place on Tuesday, April 15th in the George Sherman Union

The abstract submission form for Scholars Day 2014 will be available between March 17-31 (starting and ending at noon on those dates) at http://www.bu.edu/provost/scholars-day-2014/. Advisors will be asked to approve student abstracts by Sunday, April 6th. Students whose abstracts are not approved by the deadline will not have a designated location at the event.

All graduate students in a degree-granting program at Boston University who are also engaged in research in any area of study are invited to participate. Postdoctoral researchers are also welcome, but are not eligible for awards.

Presenters are asked to set up beginning at 9:30 a.m. Poster judging will take place between 11 a.m. and 2 p.m. Please plan to be present during as much of this time as possible, as you may need to assist the judges in their understanding of your work.

Faculty members are kindly asked to consider volunteering to judge and provide feedback, to encourage graduate students to become involved, and to persuade undergraduate students to attend.


                                                     Science Day 2014 Award Winners
                                                            Thursday, March 13, 2014

Pre-doctoral Student Poster

Daniel Moynihan, Anita Gohel, Paul Rigali, Neal Fleisher, Sharon Rich and Leslie Will. Department of Orthodontics and Dentofacial Orthopedics: “Using a Cone Beam CT Scan to Evaluate Periodontal Bone Height.”

Pre-doctoral Student Oral Presentation

Mohamed Bayoumy, Kiyoshi Sakai and Yoshihiko Yamada. Department of Molecular Biology Section at NIDCR: “The Correlative Role of Epiprofin and Tbx1 in Tooth Proliferation and Differentiation. “

Post-doctoral Student Poster

Mohammed Badri, Honghao Zhang, Nobuhiro Kamiya, Sundharamani Venkitapathi, Yoshio Ohyama, Takehito Tsuji, Tetsuo Kunieda, Yuji Mishina and Yoshiyuki Mochida. Department of Molecular and Cell Biology: “Role of Ellis-van Creveld Syndrome2 (Evc2) in Craniofacial Development.”

Post-doctoral Student Oral Presentation

Na Tian, Joshua Hansen, Dan Leffler, Ciaran Kelly, Eva Helmerhorst. Department of Molecular and Cell Biology: “Assessment of Potential Gluten-like Properties of Salivary Proline-rich Proteins.”

Fellow Poster

Michael Dion, Bing Liu, Laura Kaufman, Steven Karpas and Judith Jones. Department of General Dentistry: “Xerostomia and Salivary Hypofunction in Vulnerable Elders: Complications and Management.”

ADA Dentsply Award

Daniel Moynihan, Anita Gohel, Paul Rigali, Neal Fleisher, Sharon Rich and Leslie Will. Department of Orthodontics and Dentofacial Orthopedics: “Using a Cone Beam CT Scan to Evaluate Periodontal Bone Height.”


Research Fair  for DMD 1 and AS 1 Classes

Photos:

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Flickr


DMD’16 Student Wins National Research Award

Research is pleased to announce that Mohamed Bayoumy, DMD’16 student, attended the nineteenth Hinman Student Research Symposium Oct. 25-27, 2013 in Tennessee. The Symposium featured oral and poster presentations of research projects by dental and graduate students from dental schools across the nation. Bayoumy was the winner of the award in basic science research.

His project examined the correlative role of Epiprofin and Tbx1 in Tooth Proliferation and Differentiation. The project was directed by Dr. Yoshiko Yamada, Chief of the Molecular Biology Section at the National Institute of Dental and Craniofacial Research in Bethesda, Maryland.


AADR NSRG New England Regional Representative

Research is pleased to announce that Matthew Green DMD’15 student, a current officer of the local Student Research Group (SRG) at the GSDM, was appointed as the AADR NSRG New England Regional Representative starting September 1, 2013. In this position, Matthew communicates with the local SRGs and the local faculty and advisors at Boston University, Tufts University, Harvard University School of Medicine, University of Connecticut, Dalhousie University, the Forsyth Institute, McGill University, University of Laval, University of Montreal and the University of New England.

Please join our office in congratulating Matthew and wishing him success in this prestigious position. More information on this position and on all regional representatives can be found at:

http://iadr.enoah.com/Directories/CommitteeOfficers/tabid/9437/Default.aspx?G=AADR&M=ANSRGRR#.UjtW4YYqhxQ.

Information on the local SRG at the GSDM can be found at:

http://www.bu.edu/dental/research/predoctoral/srg/


Large Turnout for DMD 16 Student Research Presentations

August 20, 2013

Presenters and mentors with Dean Jeffrey W. Hutter, Associate Dean for Research Maria Kukuruzinska, and Assistant Director of Pre-doctoral Research Afaf Hourani
Presenters and mentors with Dean Jeffrey W. Hutter, Associate Dean for Research Maria Kukuruzinska, and Assistant Director of Pre-doctoral Research Afaf Hourani

Students, staff, and faculty filled classroom G-309 on Friday, August 9, 2013, to hear the DMD 16 Student Research Presentations. This year saw even more student researchers and guests than last year, nearly necessitating a larger room.

Eleven students, now in their second year, who completed research last spring and summer during their Applied Professional Experience (APEX) rotations shared their results. They are: Assal Abdossalehi, Amrit Basi, Mohamed Bayoumy, Nicolas Branshaw, Andrew Brattain, Jessica Finkielsztein, Jae Kwak, Yun-Young Lee, Keng Lor, Matthew Mara, and Ahmad Najjar.

Research topics spanned the gamut of oral health and ranged from public housing to head and neck pathology to genetic inquiries. After each 10-minute presentation, students answered questions from guests and mentors. Most of the students found mentors at GSDM, while one, Mohamed Bayoumy, worked with members of the National Institutes of Dental and Craniofacial Research (NIDCR). (See this week’s story about Mohamed as the recipient of the 2013 NIDCR Summer Dental Student Award.)

Dean Hutter attended and said, “I am so pleased to see an increase not only in the number of pre-doctoral students participating in research, but also the caliber of research being conducted.”

Students in the APEX first-year research rotation split their five-day week conducting either two days of research training and three days in a clinical setting or three days of researching training and two days of clinical work. Those who choose three days of research enroll in the Intensive Research Elective Course, which provides an intensive and structured research experience throughout the School of Dental Medicine curriculum for students who are interested in careers in oral health research.

The presentations are part of the Pre-doctoral Research Program (PRP). The mission of the PRP is to shape the future of dental medicine and dental education through research; to educate students from diverse backgrounds about the importance of research in dental medicine; and to mentor students to make informed decisions about research career opportunities.

“The Pre-doctoral Research Program is a wonderful opportunity for students to enhance their educational experiences at GSDM,” says Associate Dean for Research Maria Kukuruzinska. “I am delighted to see many students take advantage of the program and look forward to their future contributions to dentistry and dental education.”

Photos are available on Facebook and Flickr.

DMD’16 Student
Research Presentations

Friday, August 9, 2013
11:30AM – G309

Assal Abdossalehi and Bo Hou, Department of Orthodontics and Dentofacial Orthopedics: “Analysis of Dental and Skeletal Transverse Dimension Using Cone-beam Computed Tomography (CBCT).”

Jessica Finkielsztein and Michelle Henshaw.  Department of Health Policy and Health Services Research: “Boston Public Housing Residents’ Attitudes on Research Participation.”

Matthew Mara and Michelle Henshaw. Department of Health Policy and Health Services Research: “The Current Role of Academic-based Service Learning in Dental School Curricula.”

Jae Kwak and Radhika Chigurupati. Department of Oral and Maxillofacial Surgery: “Review of Head and Neck Pathology in Children.”

Amrit Basi and Andrew Salama. Department of Oral and Maxillofacial Surgery: “Comparison of Digital CT and OPT Image Analysis in Measuring Bone Dimensions of Free Fibula Flap Mandibular Reconstruction.”

Andrew Brattain and Richard Dinnocenzo. Department of Oral and Maxillofacial Surgery: “The Aldrete Score.”

Nicolas Branshaw and Erdjan Salih. Department of Molecular and Cell Biology: “Phosphorylation Site Distribution by Mass Spectrometry for Dentin Phosphophoryn.”

Mohamed Bayoumy, Kiyoshi Sakai and Yoshihiko Yamada. Department of Molecular Biology Section at NIDCR: “The Correlative Role of Epiprofin and Tbx1 in Tooth Proliferation and Differentiation.”

Yun-Young Lee, Bing Liu, Balazs Nemeth and Miklós Sahin-Tóth. Department of Molecular and
Cell Biology: “
Genetic Association Study Between a Common Variation of Human CTRC Gene & the Risk of Dental Caries.”

Keng Lor, Jongmin Lee and David Levin. Department of Molecular and Cell Biology: “Bimolecular Fluorescence Complementation Analysis of the Interaction Between the MAPK Mpk1 and the Transcriptional Repressor Srb11 in Response to Oxidative Stress.”

Ahmad Najjar, Wanda Wright, Leslie Will, Judith Jones and Raffi Miller. Department of General Dentistry: “Oral Health-related Quality of Life in Orthodontic Patients: Does Age Matter?”

Mohamed Bayoumy DMD 16 Cultivates Interest in Research as NIDCR Summer Dental Student Award Recipient


August 20, 2013

Dean Jeffrey W. Hutter, Mohamed Bayoumy DMD 16, and Associate Dean for Research Maria Kukuruzinska
Dean Jeffrey W. Hutter, Mohamed Bayoumy DMD 16, and Associate Dean for Research Maria Kukuruzinska

On August 12, 2013, Dean Jeffrey W. Hutter and Associate Dean for Research Maria Kukuruzinska met with Mohamed Bayoumy DMD 16 to learn about his eight-week research experience as National Institute of Dental and Craniofacial Research (NIDCR) Summer Dental Student Award recipient. They also renewed their congratulations to Bayoumy for earning the award, which he received in April.

The NIDCR Summer Dental Student Award offers talented dental students the opportunity to gain hands-on research training and exposure to cutting edge oral health research. The award is designed to give future oral health professionals a preview of a career in research.

Bayoumy traveled to Bethesda, Maryland, to conduct research at the National Institutes of Health with seven other outstanding students. He was assigned a mentor specializing in molecular biology of tooth development, which is an area of research which interests him. Dr. Yoshi Yamada, Bayoumy’s mentor, was the Principal Investigator. Bayoumy worked directly with Dr. Kiyo Sakai.

During his internship, which took place May 20–July 12, Bayoumy carried out experimental procedures such as Western Blots, immunofluorescence, prepared frozen sections, used a confocal microscope for imaging, and embryonic tooth bud extractions. He also took part in section meetings, presenting and discussing collected data, discussing lab-mates’ data, as well as literature covering topics of interest.

Bayoumy described enthusiastically to Dean Hutter and Dr. Kukuruzinska, at their meeting, his use of the Institute’s confocal microscope. This microscope is a state-of-the-art scientific instrument that produces exceptionally high resolution images, generating more precise results. Bayoumy felt very fortunate to be allowed to use the microscope to gather data during his time at NIDCR.

At the end of the training period, Bayoumy presented his findings to his colleagues and instructors at the program. He also presented his research to the students and faculty at Boston University Henry M. Goldman School of Dental Medicine (GSDM) during the Applied Professional Experience (APEX) research program presentations on August 9. His experience at NIDCR, combined with three weeks at a clinical site in Albany, New York, fulfilled his APEX requirement.

Bayoumy’s APEX presentation, which was the culmination of his research with Dr. Kiyoshi Sakai and Dr. Yoshihiko Yamada at the NIDCR internship, was titled “The Correlative Role of Epiprofin and Tbx1in Tooth Proliferation and Differentiation.”

A summary of Bayoumy’s presentation: In tooth morphogenesis, the dental epithelium and mesenchyme interact reciprocally for growth and differentiation. This interaction is critical in the formation of the proper number and shapes of teeth. Epiprofin (Epfn) and Tbx1 have been previously identified as transcription factors involved in the process of tooth development. To identify the role each transcription factor has in tooth development, Epfn and Tbx1 wild-type, heterozygous, and knockout mice were studied. Epfn -/- mice developed an excess number of teeth, enamel deficiencies, dentin defects. Tbx1 -/- mice exhibited a reduced number of teeth as well as enamel defects. The altered signaling events may underlie critical functions carried out by Epfn and Tbx1 affecting the differentiation, proliferation and maturation of ameloblasts and odontoblasts during tooth development. We aimed to study Epfn and Tbx1 in the incisors of developing mice in order to better elucidate their functionality as well as identify any possible interactions between the two transcription factors.

Bayoumy looks forward to presenting his work at the Hinman Student Research Symposium in Memphis, Tennessee, this October.

Regarding his experience as the NIDCR Summer Dental Student Award recipient, Bayoumy said:

I think this opportunity further entrenched the belief that to further progress the field of dental medicine, future dentists must approach their career with a lifelong desire to learn. I’m personally looking forward to establishing an integrated model between clinical practice and constantly researching methods to optimize care to the population.

Bayoumy continued:

I believe that research allows for a certain element of critical thinking and troubleshooting that can be applied to patient care. By honing that skill, I believe I will be better able to troubleshoot issues that may arise in patient care quickly and efficiently.

At the conclusion of the debriefing, Dean Hutter conveyed to Bayoumy that he was proud of his work and that the experience was “a success all around.”

Dean Hutter said, “Mohamed’s research work as an NIDCR Student Award recipient is a preview of his opportunity to advance the mission of the Henry M. Goldman School of Dental Medicine to shape the future of the profession through scholarship, creating and disseminating new knowledge, developing and using innovative technologies and educational methodologies, and by promoting critical thinking and lifelong learning.”


NIDCR Summer Dental Student Award

For information about the application process, go to: NIDCR Careers and Training

Contact: bugsdmr@bu.edu


HHMI Research Opportunities

Contact: bugsdmr@bu.edu

2012 Med Fellows Application Tips pdf
2012 HHMI Med Fellows Program Highlights pdf
2012 HHMI Summer Med Fellows Program Highlights pdf


APEX Presentations Reflect High Quality Research at GSDM

APEX Presenters

On August 10, 2012, students and faculty filled a classroom to standing room only to listen to nine DMD 15 students and one DMD 14 student present research they conducted during their Applied Professional Experience (APEX) rotations.

The APEX first-year research rotation is based on a five-day week. Students may either dedicate two days for research training and three days for the APEX clinical assignment or three days (30 hours) for research training and two days for the APEX clinical assignment. The latter enrolls students in the Intensive Research Elective Course and is possible if they have participated in research during the second semester of their dental education on a voluntary basis or if they have prior research experience.

From explorations of the strength of different bonding materials to investigations to isolate the genetic source of a hereditary tooth development disorder, the students addressed a wide breadth of topics in their research. Following their presentations, the students fielded questions about their research from their colleagues and mentors.

The DMD 15 presenters were Benjamin Cooperman, Suyong Jeong, Matthew Green, Sara Saremi, Christopher Connell, Sonal Chhnabhai, Isha Suri, Shan Lo, and Erin Breen. Eric Harriman DMD 14 also presented.

Regarding the presentations, Associate Dean for Research Dr. Maria A. Kukuruzinska said, “Our pre-doctoral students did an outstanding job in presenting their research projects. The presentations spanned a variety of topics and reflected high quality work and commitment on the part of the mentors. Given the short duration of the research rotation, the students showed good understanding of their projects as well as excitement and pride about their accomplishments.” Dr. Kukuruzinska continued to say that “the high number of faculty and students attending the presentations reflects the increasing recognition of research in the educational program of the school.”

Titles of the Presentations:

  • Erin Breen, Meghan Bouchie, Janice Walker, A. Sue Menko and Maria Kukuruzinska. Department of Molecular and Cell Biology & Thomas Jefferson University: “Identification of Vimentin-Enriched Cells in Embryonic Submandibular Glands After Wounding.”
  • Sonal Chhanabhai, Bruno Herrera, Thomas Van Dyke and Alpdogan Kantarci. Department of Periodontology at Forsyth Institute: “Impact of Platelets on Neutrophil Function.”
  • Christopher Connell, Guoxian Wei and Eva Helmerhorst. Department of Periodontology and Oral Biology: “Activity Profile of Gliadin-Degrading Oral Bacteria.”
  • Benjamin Cooperman, Jongmin Lee and Ekaterina V. Laz and David Levin. Department of Molecular and Cell Biology: “Regulation of the Fps1 glycerol channel.”
  • Matthew Green and Bo Hou. Department of Orthodontics: “The Consequences of Mechanical Stress on Mice Prefibroblast Mesenchymal Bone Marrow Cells.”
  • Suyong Jeong, Drew Czernick, Jess Liu, Abeer Alasmari and Erdjan Salih. Department of Periodontology and Oral Biology: “Effects of Phosvitin on PTH induced Bone Resorption.”
  • Shan Lo, Rohit Gupte and Salomon Amar. Center for Anti-Inflammatory Therapeutics: “Morphometric Analysis of Alveolar Bone Loss in a Novel Accelerated Murine Model for Chronic Periodontal Disease.”
  • Sara Saremi, Michael Faibish and Philip Trackman. Department of Periodontology and Oral Biology: “Fusion of Lox-PP and Fc Domain of IgG as Potential Cancer Therapeutics.”
  • Isha Suri, Russell Giordano and Richard Pober. Department of Restorative Sciences/Biomaterials: “Effects of Different Cements and Geometry on Bonding Strength of Titanium to Zirconia.”
  • Erik Harriman, Yoshio Ohyama, Sundharamani Venkitapathi and Yoshiyuki Mochida. Department of Periodontology and Oral Biology: “Phenotypic characterization of knockout rats in Wdr72, a causative gene for Amelogenesis Imperfecta.”

Congratulations Taylor Snider, DMD’12

May 08, 2012, Taylor Snider, DMD’12 was one of four dental students among the 45 inaugural NIH Medical Research Scholars Program class. AADR congratulated the four students and thanked their institutions for creating a culture of research that made the applications possible and successful.

“AADR is very excited that four dental students are among the 45 inaugural NIH MRSP class:
• Kyle Holmberg, The University of Minnesota School of Dentistry, Minneapolis
• Kelly Leong, Tufts University School of Dental Medicine, Boston
• Taylor Snider, Boston University Goldman School of Dental Medicine
• Robert Vander Broek, The University of Michigan School of Dentistry, Ann Arbor
Congratulations to your students and thank you for creating a culture of research in your institution that made these applications possible and successful!”
http://www.nih.gov/news/health/may2012/cc-08.htm


Pre-doctoral Research

Pre-doctoral Research Journal Club:

The Predoctoral Research office with the Student Research Group are joining forces to make a journal club, an IREC requirement, accessible to students involved in research. Two IREC students will be asked to identify a paper to be critiqued. Each student in IREC1, IREC2 and IREC3 will be asked to follow a guide to write a critique which will be part of the IREC documentation. Two students will present their critiques during an organized meeting where students can learn from each other. Based on the specific topic of the paper, a mentor will be invited to attend. All students will find this new initiative to be of great value during research training.


NIH Medical Research Scholars Program

Fourth-year DMD students qualify to apply and participate in the Medical Research Scholars Program. However, accepted fourth-year students must defer graduation before participation.

NIH Launches Medical Research Scholars Program
A new Medical Research Scholars Program for medical and dental students will begin in September 2012 in Bethesda, Maryland. The year-long program will offer research experiences with intramural investigators from across NIH in basic science laboratories, and in clinical and translational research conducted at the NIH Clinical Center. The Medical Research Scholars Program is designed for students who have completed their initial clinical rotations but does not exclude students with strong research interests from applying prior to having completed their clinical rotations.

The program is made possible through a partnership with the Foundation for the National Institutes of Health supported by a grant from Pfizer Inc and contributions from the Howard Hughes Medical Institute. Program applications will be accepted through mid-January 2012. About 40 students are expected to be admitted during the program’s first year. The goal is to accept up to 70 students as the program grows.

Support for selected students will include a stipend and resources for education enrichment such as travel to scientific meetings.

Additional details are found at www.cc.nih.gov/training/mrsp/index.html

Interested students are asked to check the FAQs for answers to questions and to contact our office at the earliest possible convenience.


The Research office is pleased to announce the launch of a new Intensive Research Elective Course (IREC)

The goal of the IREC is to provide intensive, structured experience in research throughout the dental school curriculum for students who are interested in careers in oral health research.

The course objectives include the completion of well-defined research projects, training in the design and execution of scientific studies, understanding innovative dental techniques, materials and tools, showcasing accomplishments at local, national and international scientific meetings, improving eligibility for academic appointments, becoming more informed dental clinicians, developing analytical thinking skills and contributing to the dental literature and to the discovery of new knowledge.

The IREC components include mentored research and a completed project.
Students will have three options:

  • IREC 1 – Intensive Research DMD year 1 under Apex (3 credits)
  • IREC 2 – Intensive Research DMD year 2 (2 credits)
  • IREC 3 – Intensive Research DMD year 3 (2 credits)

Pre-doctoral Research Curriculum:

The GSDM offers formal research training for credit to students. Only students who maintain a 3.0 GPA or higher in their didactic and clinical courses are considered for research training. The first-year training takes place following the completion of DMDI didactic courses during the Apex rotation from May to July. The rotation is based on a five-day week. During the rotation:

  • Students dedicate two days for research training and three days for the Apex clinical assignment. Students need to notify the Apex office and the PRP office by January 2;
  • Students dedicate three days for research training (30 hours per week) and two days for the Apex clinical assignment under the Intensive Research Program (IRP). Students need to notify the PRP office by February 1;
  • Other students can do research on a voluntary basis and are expected to spend no less than 10 hours per week in research training.
  • Advanced Standing (AS) can start research during the second semester of their dental education.
Detailed information about the Intensive Research Elective Course (IREC) can be found on
http://blackboard.bu.edu/ via the following link: