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We investigate how the many epithelial and stromal cell types of our lungs are generated during development, maintained for a lifetime and regenerated following injury.

Section of a small airway from a patient with chronic obstructive pulmonary disease (COPD) stained with antibodies against cytokeratin 5 (K5, green) and K14 (red)

To do this, we use in vivo and in vitro models to identify and test the progenitor capacity of putative stem cell populations. We posit that aberrant stem cell behaviors explain many features of common lung diseases such as cystic fibrosis, asthma, and pulmonary fibrosis.

Section of asthmatic human airway stained with antibodies against cytoskeletal proteins (green) and the basal cell-specific transcription factor p63 (red)