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The Murphy laboratory is composed of dynamic and passionate young researchers who utilize stem cell biology and regenerative medicine to combat blood disease.

Directly differentiated neurons
from ALS-disease specific iPS cells

The Murphy Lab is involved in the creation of the world's largest sickle cell disease-specific iPSC library. These cell lines are being used to recapitulate in vitro erythroid ontogeny as the basis to study globin switching in sickle cell disease-specific iPSC.

iPSC-derived blood cells

The Murphy Lab has also successfully modeled a protein folding disorder called familial amyloidosis. This work demonstrates that it is possible to model a long-term, complex, multisystem disease in a relatively short time, using lineage specified cells (hepatic, cardiac and neuronal) derived from patient-specific stem cells.

Directly differentiated neurons
from ALS-disease specific iPS cells, MAP2 (red) DAPI (blue)

Critical role of the
Megakaryocyte-Erythroid Progenitor (MEP) megakaryocytes
in the production of both red blood cells and megakaryocytes