The Murphy laboratory is composed of dynamic and passionate young researchers who utilize stem cell biology and regenerative medicine to combat blood disease.
Directly differentiated neurons
from ALS-disease specific iPS cells
The Murphy Lab is involved in the creation of the world's largest sickle cell disease-specific iPSC library. These cell lines are being used to recapitulate in vitro erythroid ontogeny as the basis to study globin switching in sickle cell disease-specific iPSC.
iPSC-derived blood cells
The Murphy Lab has also successfully modeled a protein folding disorder called familial amyloidosis. This work demonstrates that it is possible to model a long-term, complex, multisystem disease in a relatively short time, using lineage specified cells (hepatic, cardiac and neuronal) derived from patient-specific stem cells.