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The Mostoslavsky Lab is a basic science laboratory in the Section of Gastroenterology in the Department of Medicine at Boston University.

Our goal is to advance our understanding of stem cell biology with a focus on their genetic manipulation via gene transfer and their potential use for stem cell-based therapy.

FAP-specific iPSC-derived
intestinal organoids

The Mostoslavsky's Lab designed and constructed the STEMCCA vector for the generation of iPS cells, a tool that has become the industry standard for nuclear reprogramming. Project areas in the lab focuses on the use of different stem cell populations, including embryonic stem cells, induced Pluripotent Stem (iPS) cells, hematopoietic stem cells and intestinal stem cells and their genetic manipulation by lentiviral vectors.

DAPI staining FAP-specific
human iPSC colony

Our laboratory have already established a large library of disease-specific iPS cells with a particular interest in utilizing iPS cells to model diseases of the liver and the gastrointestinal system.

We have also a long standing interest in the intestinal epithelium, and in particular the development of enteroendocrine cells and their functional relevance in metabolism, diabetes and obesity.

GIP-GFP knock-in mouse
showing intestinal K cells

FAP-specific iPSC-derived intestinal
organoid with activated b-catenin and Edu staining