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KOTTON
LAB

The Kotton lab’s goal is advancing our understanding of lung disease and developmental biology with a focus on stem cell biology and gene therapy. We believe that novel treatments for many lung diseases can be realized based on a better understanding of how the lung develops as well as regenerates after lung injury.

http://www.bumc.bu.edu/kottonlab





Tia (red) Nkx2.1 (green) DAPI (blue)

We are particularly interested in defining the genomic and epigenomic programs that regulate cell fate, and a long term goal of ours is generation of the full diversity of lung lineages from pluripotent stem cells in vitro.

http://www.bumc.bu.edu/kottonlab




iPSC-derived lung epithelial cells
reseeding bioengineered lung

We have established a major research program based on the use of patient-specific iPS cells for disease modeling and the hope that it will lead in the near future to the development of novel regenerative medicine therapies.

http://www.bumc.bu.edu/kottonlab


Patient-specific iPS cell colony,
generated from a child with interstitial lung disease

http://www.bumc.bu.edu/kottonlab





Mouse lung Nkx2-1 Green CCSP Red