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Induced Pluripotent Stem Cells (iPSCs) generated by forced overexpression of defined transcription factors in somatic cells hold great promise for human disease research and personalized medicine. iPSCs show extensive self-renewal and have the ability to become any cell type in the body, providing an inexhaustible source of cells for in vitro disease modeling studies, screening of pharmacological compounds and regenerative therapies. The Center for Regenerative Medicine (CReM) iPSC Core was created to expedite the use of iPSC technology by providing essential services and support to on-campus investigators and the broader scientific community. To achieve this goal the CReM iPSC Core will:

iPS Cell Colonies


Induced pluripotent stem cells are derived from the donated skin or blood cells of adults and, with the reactivation of four genes, are reprogrammed back to an embryonic stem cell-like state. Like embryonic stem cells, iPS cells can be differentiated toward any cell type in the body, but they do not require the use of embryos. Since this discovery four years ago, our knowledge about iPS cells has exponentially expanded.

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Embryonic lung: TTF1-GFP mouse


CReM Investigators Publish Differentiation of Stem Cells to Lung Progenitors See the original publication in Cell Stem Cell: Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells. See the article in BU Today!

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CReM researchers Gustavo Mostoslavsky (from right), Darrell Kotton, and George Murphy.