People

Research Interests

Molecular Biotechnology and Genomics Schizophrenia Breast Cancer Twin Studies

Current Research

Dr. Smith's research brings novel approaches developed at the interface of genomics/genetic and biotechnology to complex disease studies. A major focus is on preventing schizophrenia by understanding how a significant number of monozygotic (aka identical) twins can be discordant for disease. Other research takes a combinatorial chemistry approach to isolate aptamers (DNA mimics of antibodies) for use as cancer tumor targeting reagents. Here, the goal is to develop effective targeted therapies for cancer treatment and diagnositic modalities while minimizing damage to bystander cells. Another focus is on the development of new DNA technologies for detecting and diagnosis disease.

Selected Recent Publications

Sabanayagam C.R., Smith C.L., Cantor C.R. "Oligonucleotide immobilization on micropatterned streptavidin surfaces" Nucleic Acids Research 28(8): E33 (2000)

Hatch, A, T. Sano, J. Misasi, C.L Smith "Mutation Detection using Rolling Circle Amplification (RCA) and Immobilized DNA probes" Genetic Analysis (Biomolecular Engineering) : 15:35-40 (1999)

Cantor, C.R, C.L Smith "Genomics: The Science and Technology Behind the Human Genome Project" Wiley and Sons, Inc : 1-596 (1999)

Graber J.H., Smith C.L., Cantor C.R. "Differential sequencing with mass spectrometry" Genet Anal 14(5-6): 215-9 Review (1999)

Hatch A., Sano T., Misasi J., Smith C.L. "Rolling circle amplification of DNA immobilized on solid surfaces and its application to multiplex mutation detection" Genet Anal 15(2): 35-40 (1999)

Broude N.E., Storm N., Malpel S., Graber J.H., Lukyanov S., Sverdlov E., Smith C.L. "PCR based targeted genomic and cDNA differential display" Genet Anal 15(2): 51-63 (1999)