People
Primary Faculty
Jerome C. Mertz Ph.D.
Professor, Biomedical Engineering
Ph.D., Physics, Université Paris VI & University of California, Santa Barbara
B.A., Physics Princeton University
CV: Link to Curriculum Vitae (pdf)
phone: (617) 358-0746
fax: (617) 353-6766
email: jmertz@bu.edu
office: LSEB 202
Research Interests
Development and applications of novel optical microscopy techniques for biological imaging.
Current Research
- Development of nonlinear microscopes based on femtosecond lasers.
- Application of two-photon excited fluorescence (TPEF) microscopy to deep imaging in brain tissue and visualization of endogenous fluorescence for clinical applications.
- Applications of second-harmonic generation (SHG) microscopy to cell membrane potential imaging and the photocontrol of chromophore orientation dynamics in membranes.
- Investigation of interferometric contrast mechanisms based on optical coherence tomography (OCT) or nonlinear detection (Auto-confocal microscopy). Application to thick tissue imaging.
Selected Recent Publications
C. Yang, J. Mertz "Transmission confocal laser scanning microscopy with a virtual pinhole based on nonlinear detection" Opt. Lett. 28: 224-226 (2003)
T. Pons, L. Moreaux, O. Mongin, M. Blanchard-Desce, J. Mertz "Mechanisms of membrane potential sensing with second harmonic generation microscopy" J. Biomed. Opt. 8: 428-431 (2003)
T. Pons, L. Moreaux, J. Mertz "Photo-induced flip-flop of amphiphilic molecules in lipid bilayer membranes" Phys. Rev. Lett 89: 288104 (2002)
L. Moreaux, O. Sandre, S. Charpak, M. Blanchard-Desce, J. Mertz "Coherent Scattering in Multi-harmonic generation microscopy" Biophys. J. 80: 1568-1574 (2001)
L. Moreaux, O. Sandre, J. Mertz "Membrane imaging by second-harmonic generation microscopy" J. Opt. Soc. Am. B. 17: 1685-1694 (2000)
