People

Research Interests

Dr. Meller's research is directed toward the development of novel experimental techniques for the study of biomolecular interactions and dynamics, at the single molecule or at the single complex level. In particular, his research is focused on:

• Employing nanopore force spectroscopy to study RNA unfolding and re-folding kinetics
• DNA switches and transcription initiation kinetics
• RNA helicases activity
• Mapping of transcription factors interactions with DNA
• Ultra-fast DNA sequencing
• Development of novel optical methods for single molecule detection in biomedical applications

Selected Recent Publications

Mathé J., A. Arinstein, Y. Rabin, A. Meller "Equilibrium and irreversible unzipping of DNA in a nanopore" Europhysics Letters 73: 128-134 (2006) abstract

V. Viasnoff, A. Meller, H. Isambert "DNA nanomechanical switches under folding kinetics control" Nano Letters 6: 101-104 (2006) abstract

Sabanayagam C., J. Eid, A. Meller "Long timescale blinking kinetics of cyanine dyes and its effect on single molecule FRET" Journal of Chemical Physics 123: 224708 (2005) abstract

Mathé J., A. Aksimentiev, D. Nelson, K. Schulten, A. Meller "Orientation discrimination of single stranded DNA inside the a Hemolysin membrane channel." Proceedings of the National Academy of Science 102: 12377-12382 (2005) abstract

Sabanayagam C., J. Eid, A. Meller "Using fluorescence resonance energy transfer to measure distances along individual DNA molecules: corrections due to non-ideal transfer" Journal of Chemical Physics 122(6): 0611031-5 (2005) abstract

Mathé J., H. Visram, V. Viasnoff, Y. Rabin, A. Meller "Nanopore unzipping of individual DNA hairpin molecules" Biophysics Journal 87: 3205-12 (2004) abstract