People

Affiliated Faculty

Research Interests

We are interested in the evolutionary dynamics of biological networks, in particular in the interplay between response to genetic and environmental perturbations, genomic-level functional organization, and optimal adaptation. Our goals include developing constraint-based models to study the regulatory and evolutionary dynamics of metabolic networks across different organisms, cell types, and interacting cell populations.

Selected Recent Publications

Daniel Segrè, Alexander DeLuna, George M. Church, Roy Kishony "Modular epistasis in yeast metabolism " Nature Genetics 37(1): 77-83 (2005) abstract

Barak Shenhav, Daniel Segrè, Doron Lancet "Mesobiotic emergence: molecular and ensemble complexity in early evolution" Advances in Complex Systems 6 (1): 15-35 (2003)

Daniel Segrè , Jeremy Zucker, Jeremy Katz, Xiaoxia Lin, Patrik D'haeseleer, Wayne P. Rindone, Peter Kharchenko, Dat Nguyen, Matthew A. Wright and George M. Church "From annotated genomes to metabolic flux models and kinetic parameter fitting " Omics 7(3): 301-316 (2003)

Daniel Segrè, Dennis Vitkup, George Church "Analysis of Optimality in Natural and Perturbed Metabolic Networks" Proc. Natl. Acad. Sci. USA 99(23): 15112-15117 (2002)

Daniel Segrè, Dafna Ben-Eli, David Deamer, Doron Lancet "Origins Life Evol. Biosphere" The Lipid World 31: 119-145 (2001)

Daniel Segrè, Dafna Ben-Eli, Doron Lancet "Compositional Genomes: Prebiotic Information Transfer in Mutually Catalytic Noncovalent Assemblies" Proc. Natl. Acad. Sci. USA 97(8): 4112-4117 (2000)