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| Laboratory of Stereology and Morphometry |
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| Estimating number, volume and size in biological systems. |
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The director of the Neuroanatomical Core that encompasses the lab is Dr. Neil Kowall,
Department of Neurology . The PI for the entire project is Dr. Krzysztof Blusztajn, Department of
Pathology and Laboratory Medicine. The Stereology histology needs are met by the histology lab at
the Geriatric Research, Education and Clinical Center (GRECC) at the Bedford VAMC, Bedford, MA.
That lab is staffed by a number of highly skilled research assistants with expertise in immunohistochemistry
and histology. Additional collaborations with Dr. Subimal Datta of the Sleep Research Laboratory at BUMC
have been very fruitful.
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Dr. Donald Siwek, PhD |
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Dr. Siwek has served as the Data Manager for the Boston University Alzheimer's
Disease Center (1995 Ð 2001) and is member of the Gross Anatomy Teaching Staff. Interests include
neurobiology of sleep, neuronal morphology, imaging and image analyses, stereology, gross anatomy
and astronomy. |
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Dr. Neil Kowall, MD |
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Dr. Kowall is a neurologist and the director of the Bedford GRECC and the Director
of the Boston University Alzheimer's Disease Center. His interests include neurodegenerative disease
and the role of oxidative damage in those diseases. |
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Dr. Jan Krzysztof Blusztajn, PhD |
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Dr. Blusztajn is Professor of Pathology and Laboratory Medicine and Research Professor
of Psychiatry. He is the PI for the "Aging Of Brain--Effects Of Perinatal Nutrition" grant that funds the
Stereology Lab. His interests are in the role of membrane lipid-derived second messenger molecules as
possible modulators of cell transformation, and the regulation of the expression of the cholinergic phenotype,
i.e. of the genes coding for proteins involved in the synthesis (choline acetyltransferase) and the storage
(the vesicular acetylcholine transporter) of the neurotransmitter, acetylcholine |
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Dr. Subimal Datta, PhD |
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Dr. Datta's interests include: 1. understanding how single cells of the brain
and their specific chemical signals (neurotransmitters and neuromodulators) are organized at the level
of population ensembles to determine the global behavioral states of waking and sleep; 2. studying the
neurophysiological and molecular mechanism of state-dependent learning and memory consolidation;
and 3. studying the consequences of altered brain development in the behavioral states of wake-sleep cycle. |
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