Experimental approaches include cell culture, motor performance testing of mice, mid and high-throughput enzyme assays, protein binding assays, genetic and chemical screens, protein analysis by western blotting, 2D Differential In-gel electrophoresis (2D-DIGE), and column chromatography.

Systems used include cell culture and animal models of demyelination and other neurological disorders involving proteotoxicity (Amyotrophic lateral Sclerosis (ALS), and Huntington's disease, and Alzheimer's disease).