Laboratory of Cellular Biology of the Basal Ganglia and Motor Disorders
Jean-Jacques R. Soghomonian, Ph.D.
Associate Professor
Phone: 617-638-4511
Fax: 617-638-4216
Email: jjsogho@bu.edu
Location: R - 1014, BUSM
CV

Dr. Soghomonian received his doctorate in Neurological Sciences from the University of Montreal. He completed postdoctoral training at the Medical College of Pennsylvania and the University of Pennsylvania and then worked as an Assistant Professor in the Department of Physiology and Anatomy at Laval University (Canada). He joined the Department of Anatomy and Neurobiology at Boston University School of Medicine in 1998. Dr. Soghomonian maintains an active NIH-funded research program on the anatomical and functional organization of the basal ganglia in the normal brain and in experimental models of Parkinson's disease. He focuses on the pathophysiology of Parkinson's disease and l-DOPA-induced dyskinesia. His is also interested in the mechanisms involved in the regulation of GABA-mediated signaling in the basal ganglia and the role of the basal ganglia in sensori-motor learning. The laboratory uses a combination of anatomical, quantitative image analysis and molecular biology techniques.

Dr. Soghomonian teaches lectures and laboratories in the courses of Microscopic Anatomy and Neuroscience. He is also involved in the teaching of departmental graduate courses.

Dr. Soghomonian is currently director of graduate studies in the Department of Anatomy and Neurobiology. He serves on the MD-PhD admission committee at Boston University School of Medicine and on the steering committee of the Interdepartmental Program in Biomedical Neuroscience (IPBN).

Nielsen KM, Soghomonian JJ. Normalization of glutamate decarboxylase gene expression in the entopeduncular nucleus of rats with a unilateral 6-hydroxydopamine lesion correlates with increased GABAergic input following intermittent but not continuous levodopa. Neuroscience. 2004;123(1):31-42.
Nielsen KM, Soghomonian JJ. Dual effects of intermittent or continuous L-DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6-OHDA lesion. Synapse. 2003 Sep 15;49(4):246-60.
Laprade N, Soghomonian JJ. Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates. Synapse. 1999 Jul;33(1):36-48.
Soghomonian JJ, Martin DL. Two isoforms of glutamate decarboxylase: why? Trends Pharmacol Sci. 1998 Dec;19(12):500-5. Review.
Dr. Mark Moss
Terri Ach, MS.
Dr. Peter Bergethon
Dr. Marlene Oscar Berman
Dr. Gene Blatt
Dr. Todd Hoagland
Dr. Richard Hoyt
Dr. Robert Joseph
Dr. Thomas Kemper
Dr. Ronald Killiany
Dr. Dae-Shik Kim
Dr. Jennifer Luebke
Dr. Tara Moore
Dr. Kalidas Nandy
Dr. Deepak Pandya
Dr. Monica Pessina
Dr. Alan Peters
Dr. Daniela Plesa Skwerer
Dr. Itamar Ronen
Dr. Douglas Rosene
Dr. R. Jarrett Rushmore
Dr. Ivelisse Sanchez
Dr. Julie Sandell
Dr. Donald Siwek
Dr. Jean-Jacques Soghomonian
Dr. Helen Tager-Flusberg
Dr. Louis Toth
Dr. Antoni Valero-Cabre
Dr. Deborah Vaughan
Dr. Elizabeth Whitney
Dr. Irina Zhdanova
Dr. Charles Zucker