TL1 Pre-Doctoral and Post-Doctoral Fellowships in Regenerative Medicine
We are delighted to announce that the BU-CTSI will support up to 6 laboratory-based pre-doctoral and 2 post-doctoral fellows as part the CTSI training program in regenerative medicine. If you are interested in this support please submit an application and review the required materials and criteria below. Applications that are not complete will not be reviewed.
TL1: Regenerative Medicine Training Program
The BU-CTSI TL1 Pre-Doctoral and Post-Doctoral Fellowships in Regenerative Medicine is committed to increasing the diversity of the research workforce and strongly encourages applications from underrepresented, racial and ethnic groups (UREGs).
Regenerative medicine represents the next evolution of medical treatments through the replacement, engineering, or regeneration of damaged human cells, tissues, or organs to restore normal function. This groundbreaking field of medicine truly encompasses the concept of “bench to bedside” translational and personalized medicine research. Both the CTSI and BU School of Medicine place a strong emphasis on regenerative medicine, which also plays a central role in NCATS’ mission of expediting personalized medicine and the discovery and rapid delivery of cell-based therapeutic and pharmacologic approaches to market.
The result of interest sparked by an Affinity Research Collaborative (ARC) on iPSC, the Regenerative Medicine Training Program (RMTP)—CTSI’s transformative 2-year TL1 program—aims to support the creation of a pipeline of well-trained scientists and future leaders in the field of translational research by:
- Providing an innovative, integrative, and interdisciplinary training program, based on CTSA nationally developed competencies and leveraging the unique and internationally recognized strength of BU;
- Facilitating translational team science interactions, synergistically bridging research strengths with interdisciplinary approaches;
- Engaging pre- and post-doctorates who have already excelled and whose research would be transformed with the inclusion of regenerative medicine expertise and resources, making “today’s trainees the teachers of tomorrow;”
- Offering ongoing career and research guidance by mentors (primary and secondary) who have led successful, cross-disciplinary, sustained teams in groundbreaking areas and participated in the train-the-mentor program.
Created in collaboration with the Center for Regenerative Medicine (CReM), with its extensive faculty expertise, vast networking capabilities, and state-of-the-art facilities and resources, the RMTP TL1 will provide scientific expertise, laboratory, and financial support to trainees from many different departments and biological disciplines across BU, such as dentistry, medicine, surgery, pediatrics, geriatrics, cardiology, and biomedical engineering.
Integrating CReM as a training facility is a win-win for students and the institution alike. Regenerative medicine has been the most sought after discipline for BU School of Medicine PhD applicants, and the CReM faculty receives the greatest number of requests from matriculating students to conduct their PhD thesis work. Until the establishment of the RMTP TL1 program, only a limited number of students could be accepted. The program will thus not only increase the capacity of trainees within the CReM but also extend the scope of regenerative medicine research to other disciplines.
Tools to develop TL1 competencies, some examples
- Creation of a Thesis Committee to provide a well-rounded approach to thesis aims
- Participation in national stem cell workshops
- Responsible Conduct of Research coursework
- CREST workshops on grant writing skills
- Advanced presentation skills training
- Research implementation and statistical support through courses such as Stem Cell Biology, Molecules to Molecular Therapeutics and Biostatistics with Computing.
- CReM seminars by top national and international scientists
- Seminars and workshops on the importance of understanding diversity in the context of translational studies and data outcome
- Creation of Individual Development Plans to maps out career paths
In addition to eligible postdoctoral fellows, the RMTP TL1 is open to the top PhD students in the Biomedical Sciences at BU’s Medical Campus and those in Biomedical Engineering, Biology and Chemistry at BU Charles River Campus. Students must apply in their second year of graduate school.
Darrell Kotton, MD will continue as the PI and Program Leader of the RMTP TL1, having led the program for the past 4 years. Dr. Kotton joined BU’s faculty in 2004 and is the David C. Seldin Professor of Medicine, Professor of Pathology and Laboratory Medicine, and is the founding Director of the Centerfor Regenerative Medicine (CReM) of BostonUniversity and Boston Medical Center. Dr. Kotton continues to see patients as a pulmonary and critical care medicine physician (20% clinical effort) while leading an NIH-funded basic science research program developing pluripotent stem cell approaches to understand and treat a variety of genetic lung diseases. As an educator, Dr. Kotton has won accolades, such as the BU GMS 2018 Educator of the Year Award and the BU Department of Medicine’s 2014 Robert Dawes Evans Senior Mentoring Award. He has personally trained 25 graduate students and postdoctoral PhD fellows in his laboratory and has participated in the training of 50 additional medical students and pulmonary fellows. He has won the Pulmonary Center’s teaching excellence award and has chaired or served on 10 PhD thesis committees to date. Graduates of his laboratory have gone on to become faculty members in academic medicine (1 Associate Professor, 6 Assistant Professors, 1 Research Assistant Professor, 1 Instructor), laboratory leading PI’s (Drs. Wilson, Ikonomou, Hawkins, Jamal, and Hurley), and industry scientists. As an ambassador of the TL1 program nationally, Dr. Kotton also leads our efforts to share the program, its iPS cell and organoid bank, and our training modules across all CTSI sites, as exemplified by our NCATS U01 (PI, Dr. Kotton) supporting national sharing of the iPSC network. As a physician-scientist Dr. Kotton serves as the founding Co-Director of Boston Medical Center’s Alpha-1 Center, a clinical Center dedicated to the care of patients and their families suffering from the inherited disease, alpha-1 antitrypsin deficiency. He is an elected member of the American Society of Clinical Investigators, and his research has been recognized with numerous awards from the American Thoracic Society and the Alpha-1 Foundation.
Chris Chen, MD, PhD will be an Associate Leader of the TL1 whose role is integration of the School of Engineering within the RMTP. Dr. Chen is Professor of Biomedical Engineering, has served as a TL1 mentor on our RMTP for several years, and has been an instrumental figure in the development of engineered cellular microenvironments to understand how cells build tissues. His group pioneered the use of micro- and nanofabrication technologies to identify the underlying mechanisms by which cells interact with materials and each other to build organized tissues, and to apply this knowledge in the biology of stem cells and tissue vascularization. He has also served in numerous leadership roles to foster the interface between engineering, biology, and medicine. In addition to serving as a professor in the Department of Biomedical Engineering at BU he also has an appointment at the Wyss Institute for Biologically Inspired Engineering at Harvard University. He served at the University of Pennsylvania as the Skirkanich Professor of Innovation and founding director of the Center for Engineering Cells and Regeneration prior to his current appointment. Henow serves as founding Director of the Killachand Center for Biological Design at BU, a newly launched state of the art physical space for research and training in regenerative medicine related research. He currently works closely with Dr. Kotton to integrate shared trainees and resources across both medical and Charles River campuses of BU providing an unparalleled environment for trainees to experience the full breadth of translational regenerative medicine research and tissue engineering.
Elke Muhlberger, PhD will be an Associate Leader of the TL1 whose role is to ensure integration of the RMTP with our National Emerging Infections Diseases Laboratory (NEIDL), BU’s unique BL4 facility focused on injury and repair associated with emerging infectious diseases. Dr. Muhlberger is a veteran mentor of our TL1 program. She has co-mentored trainees studying the biology of pathogens responsible for hemorrhagic fevers and their associated multi-organ responses to injury. Together with our Center for Regenerative Medicine, she has mentored TL1 graduate students who have developed iPSC-derived human, primate, and bat hepatocytes that serve as potential reservoirs for Ebola viral infections. Most recently Dr. Muhlberger has worked with Drs. Kotton, Mostoslavsky, and Chen to integrate regenerative medicine research approaches between BU’s NEIDL, CReM, and Biomedical Engineering Programs. She currently is Associate Professor of Microbiology, Director of BUs Biomolecule Production Core, and an expert in filoviruses that cause hemorrhagic fever and associated host-pathogen interactions.
Matt Jones, PhD will be a Trainee Advisor of the TL1 whose role is to interact with our valuation group and lead the predoctoral training component of the RMTP. Dr. Jones became faculty at BU School of Medicine in 2008 and is now an Associate Professor of Medicine. In his role as educator and a leader in graduate student education at BU, Dr. Jones serves as the Director of the Graduate Program in Molecular and Translational Medicine (GPMTM), the largest PhD training program on our medical campus with approximately 30 PhD and MD/PhD students, and the largest component of our umbrella graduate student program. In his capacity as Director of the GPMTM, Dr. Jones for the past 4 years has focused on recruiting, mentoring, and retaining students in the TL1 program (22 to date) who are interested in regenerative medicine related aspects of translational research. In addition to mentoring PhD, MD/PhD, and pulmonary fellows conducting research, Dr.Jones is an experienced, R01-funded Principal Investigator whose focus is on the mechanisms governing thepost-transcriptional regulation of cytokine expression during infection.
Jason Rock, PhD will be a Trainee Advisor of the TL1 whose role is to direct the postdoctoral training component of the RMTP and ensure its integration with the extensive post-doctoral training components detailed for clinician-researchers in our KL2 application. Dr. Rock was recently recruited from the University of California, San Francisco to BU where he is an Associate Professor of Medicine with his laboratory housed in the CReM. His joint appointment as faculty in our NEIDL ensures integration with that marquee program at BU, along with Dr. Muhlberger. At BU Dr. Rock is actively engaged in graduate education, and serves as Associate Director of the Graduate Program in Molecular and Translational Medicine and on the Academic Planning Council. In addition, Dr. Rock served as the Chair of the Graduate Council at UCSF and was a member of the University of California Systemwide Coordinating Committee on Graduate Affairs. As a PI Dr. Rock’s NIHfunded laboratory uses in vivo and in vitro models to study endogenous stem/progenitor cells of the lung. Graduates from his laboratory include: 3 PhD graduate students, 2 PhD postdoctoral fellows and 1 pulmonary fellow.
|Trainee||Appointment Start Date||Appointment End Date|
|Amalia Capilla Villanueva||6/1/2016||5/31/2018|
|Trainee||Appointment Start Date||Appointment End Date|
|Timothy A. Norman||6/1/2016||5/31/2017|
Master of Science Program in Biomedical Research: An Interdisciplinary Approach to Science
The Master of Science in Biomedical Research Technologies is a new one-year program designed to prepare future experts with a solid grasp of the principles underlying various research core technologies operations, its relevance to an array of biomedical problems and the technical skills to implement these technologies. Visit https://www.bumc.bu.edu/gms/brt/ to learn more.