Ian Mahar

Post-Doctoral Fellow

Education
PhD

Background

Ian completed his PhD in Neuroscience at McGill University, working with the McGill Group for Suicide Studies at the Douglas Mental Health University Center, before joining the CTE Center as a Postdoctoral Research Fellow. His thesis investigated the role of neurotrophic factors in hippocampal neuroplasticity and mood regulation.

Research interests

Ian’s research focus is on the etiology and treatment of psychiatric conditions. Ian is currently researching the neurobiology of psychiatric phenotypes in CTE, such as depression and suicidality. He is mentored by Dr. Ann McKee.

Awards/memberships

Ian is a Fonds de Recherche du Québec – Santé (FRQS) Postdoctoral Fellow, has received a FRQS Doctoral Fellowship, and is a Steven S. Zalcman Memorial Award recipient. He has been a member of the Association for the Study of Neurons and Diseases, Canadian Association for Neuroscience, International Academy of Suicide Research, International Brain Research Organization, Sociedade Brasileira de Neurociências e Comportamento, and Society for Neuroscience.


Recent publications

Mahar, I., Labonte, B., Yogendran, S., Isingrini, E., Perret, L., Davoli, M.A., Rachalski, A., Giros, B., Turecki, G., Mechawar, N. (2017). Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. Translational Psychiatry 7: e1161.

Mahar, I.*, Albuquerque, M.S.*, Mondragon-Rodriguez, S., Cavanagh, C., Davoli, M.A., Chabot, J.-G., Mechawar, N., Williams, S., Quirion, R. and Krantic, S (2016). Phenotypic alterations in hippocampal NPY- and PV-expressing interneurons in a presymptomatic transgenic mouse model of Alzheimer’s disease. Front. Aging Neurosci 8: 327. (*Co-authorship.)

Mahar, I., MacIsaac, A., Kim, J.J., Qiang, C., Davoli, M.A., Turecki, G., Mechawar, N. (2016). Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus and characterization of immature neurons along the septotemporal axis. Sci. Rep.

Juster, R.P., Seeman, T., McEwan, B.S., Picard, M., Mahar, I., Mechawar, N., Sindi, S., Smith, N.G., Souza-Talarico, J., Sarnyai, Z., Lanoix, D., Plusquellec, P., Ouellet-Morin, I., and Lupien, S.J. (2015). Social Inequalities and the Road to Allostatic Load: From Vulnerability to Resilience. In Dante Cicchetti (Ed.), Developmental Psychopathology (3rd Edition). Hoboken, NJ: Wiley.

Albuquerque, M.S.*, Mahar, I.*, Davoli, M.A., Chabot, J.-G., Mechawar, N., Quirion, R. and Krantic, S (2015). Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease. Front. Aging Neurosci. 7:30. (*Co-authorship.)

Mahar, I., Bambico, F.R., Mechawar, N., Nobrega, J.N. (2014). Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience & Biobehavioral Reviews 38: 173-192.

Mahar, I., Bagot, R.C., Davoli, M.A., Miksys, S., Tyndale, R.F., Walker, C.D., Maheu, M., Huang, S-H., Wong, T.P., & Mechawar, N. (2012). Developmental Hippocampal Neuroplasticity in a Model of Nicotine Replacement Therapy during Pregnancy and Breastfeeding. PLoS ONE 7(5): e37219.

Labonte, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M.J., & Turecki, G. (2012). Genome-Wide Epigenetic Regulation by Early-Life Trauma. Archives of General Psychiatry 69(7): 722-731.

Mahar, I., Tan, S., Davoli, M.A., Dominguez-Lopez, S., Qiang, C., Rachalski, A., Turecki, G., & Mechawar, N. (2011). Peripheral neuregulin-1 administration increases hippocampal neurogenesis and induces antidepressant effects. PLoS ONE 6(10): e26610.

Dominguez-Lopez, S., Mahar, I., Bambico, F.R., Labonte, B, Leyton, M., & Gobbi, G. (2011). Short term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. Journal of Psychopharmacology 26(6): 830-44.

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