Thor Stein, M.D., Ph.D.

Assistant Professor of Pathology and Laboratory Medicine
Associate Director of the Neuropathology Core of the Boston University Alzheimer Disease Center


Phone: 857-364-5612
Fax:
857-364-6193
Email: tdstein@bu.edu
Location:
VA Boston Healthcare System, 150 South Huntington Avenue, Bldg. 1A, Rm. 324, Jamaica Plain, MA 02130

Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Boston University School of Medicine.

Research Interests:

Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:

Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:

Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

Selected Publications:

Augustinack JC, Huber KC, Postelnicu GM, Kakunoori S, Wang R, van der Kouwe AJW, Wald LL, Stein TD, Frosch MP, Fischl B. Entorhinal verrucae geometry is coincident and correlates with Alzheimer’s lesions: a combined neuropathology and high-resolution ex vivo MRI analysis. Acta Neuropathol 2012; 123(1):85-96.

Nozari A, Dilekoz, E, Sukhotinsky I, Stein T, Eikermann-Haerter K, Liu C, Wang Y, Frosch MP, Waeber C, Ayata C, Moskowitz MA. Microemboli may link spreading depression migraine aura and patent foramen ovale. Ann Neurol 2010;67(2):221-9.

Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of sAPPalpha in APPSw mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 2004;24(35):7707-17.

Li J*, Stein TD*, Johnson JA. Genetic Dissection of Systemic Autoimmune Disease in Nrf2 Deficient Mice. Physiol Genomics 2004;18(3):261-72. *first two authors contributed equally
Diffee GM, Seversen EA, Stein TD, Johnson JA. Microarray expression analysis of effects of exercise training reveals an increase in atrial myosin light chain 1 in rat ventricle. Am J Physiol Heart Circ Physiol 2003;284: H830–H837.

Stein TD, Fedynyshyn JP, Kalil RE. Circulating Autoantibodies Recognize and Bind Dying Neurons Following Injury to the Brain. J Neuropathol Exp Neurol 2002;61(12): 1100-1108.

Stein TD, Johnson JA. Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein is Associated with Increased Levels of Transthyretin and Activation of Cell Survival Pathways. J Neurosci 2002;22(17): 7380-7388.

Stein T, Moritz C, Quigley M, Cordes D, Haughton V, Meyerand E. Functional Connectivity in the Thalamus and Hippocampus Studied with Functional MR Imaging. Am J Neuroradiol 2000;21:1397-1401.

Stein TD, DeJesus OT. Effect of 6-fluoro-m-tyrosine on dopamine release and metabolism in rat striatum using in vivo microdialysis. Brain Res 2000;884(1-2): 192-195.