Quantification of Septal Thickening in Scleroderma Patients Utilizing Hyperpolarized 129Xe MRI

Main Inclusion criteria:

(1) Patients with Diagnosis of Scleroderma (Limited or Diffuse) with Interstitial Lung Disease (ILD) confirmed by HRCT within the previous 5 years

(2) Patients with FVC% predicted between 50-90% predicted


Exclusion Criteria:

(1) Diagnosis or suspected Pulmonary Arterial Hypertension (PAH)

(2) Patients who have asthma, currently smoking and need supplementary oxygen therapy

(3) Patients with MR contraindications such as electrical implants (cardiac pacemaker), ferromagnetic implants (prostheses) and claustrophobia