Biomarkers in Scleroderma

INCLUSION CRITERIA

• Must meet the American College of Rheumatology criteria for systemic sclerosis with diffuse or limited cutaneous involvement, patients with primary pulmonary hypertension or not have a known autoimmune illness (controls)
• Patients with diffuse cutaneous disease will only be recruited who are within 2 years of first non-Raynaud’s disease manifestation or have manifest progressive skin or lung disease
• Male or female patients equal or greater than 18 years of age
• Hemoglobin greater than 8.5
• Able and willing to give written informed consent and comply with the study protocol